The Chair of Medical Radiation Physics combines Medical Imaging and Molecular Radiotherapy as fundamental components of innovative concepts of precision medicine (Theranostics). The research work therefore focuses on the optimization of individual diagnostics and therapy with special emphasis on the translation of theoretical methods into clinical routine.
The focus of the professorship for Medical Radiation Physics is on
- optimization of Molecular Radiotherapy under optimal utilization of previous knowledge from various sources such as
- from individual functional and anatomical imaging
- from previous knowledge about the respective patient population and
- from general previous knowledge regarding anatomical, (patho)physiological and (radio)biological characteristics - conducting in silico (clinical) trials to improve the therapy planning of molecular radiotherapy,
- development and implementation of new physiologically based pharmacokinetic (PBPK) and pharmacodynamic (PD) models and translation from research to clinical practice,
- improvement of evaluation methods for functional imaging.
Publications
The following link gives an overview of the publications of the respective person.
Univ.-Prof. Dr. Gerhard Glatting (Dipl.-Phys.)
Dr. Elham Yousefzadeh-Nowshahr (MSc)
Job offers
Master theses/Bachelor theses
We offer interdisciplinary topics with a focus on biology, radiochemistry, physics, medical physics, image processing, etc.
Please send your application to Prof. Dr. Gerhard Glatting.
Scholarship Applications
We are happy to host Marie Skłodowska-Curie Actions (MSCA) Individual Fellowships as well as German Academic Exchange Service scholars. In case of interest, please contact Prof. Dr. Gerhard Glatting.
Herzlichen Glückwunsch an Dr. Deni Hardiansyah zum Gewinn des 1. Tomio-Inoue-Preises auf dem 16. Asiatischen und Ozeanischen Kongress für Nuklearmedizin und Biologie (AOCNMB). Die vorgestellte Arbeit beruht auf einer Kooperation der Ulmer Gruppe für Medizinische Strahlenphysik mit der Abteilung für Medizinische Physik und Biophysik der Universitas Indonesia und der Arbeitsgruppe Medizinische Physik in der Klinik für Nuklearmedizin am Uniklinikum Freiburg.
In der Studie mit dem Titel „Single-time-point kidneys and tumor absorbed dose calculation during [177Lu]Lu-PSMA-617 therapy using non-linear mixed-effects modeling“ wurde gezeigt, dass eine einzige SPECT/CT-Messung 2 Tage nach der Injektion die Energiedosen von Nieren und Tumoren bei der [177Lu]Lu-PSMA-617-Therapie gut vorhersagen kann. Der neu entwickelte „STP-NLME“-Ansatz übertrifft die häufig verwendete einfache STP-Methode.
Der Tomio Inoue Award ist eine Auszeichnung, die im Bereich der Nuklearmedizin an Wissenschaftler und Forscher vergeben wird, die einen bedeutenden Beitrag auf diesem Gebiet leisten. Der Preis ist nach Tomio Inoue benannt, einer führenden Persönlichkeit auf dem Gebiet der Nuklearmedizin und Biologie, der für seine wissenschaftlichen Beiträge zur Entwicklung der medizinischen Bildgebungstechnologie und nuklearmedizinischer Therapien anerkannt ist.
Die Kooperation der Ulmer Gruppe für Medizinische Strahlenphysik mit der Abteilung für Medizinische Physik und Biophysik der Universitas Indonesia und der Arbeitsgruppe für Medizinische Physik in der Klinik für Nuklearmedizin am Uniklinikum Würzburg wurde für ihren Beitrag zur Jahrestagung der amerikanischen Gesellschaft für Nuklearmedizin und Molekulare Bildgebung (SNMMI) mit dem "International Best Abstract Award for Indonesia" ausgezeichnet.
Die entwickelte Methode optimiert die Genauigkeit und damit die Reproduzierbarkeit zwischen verschiedenen Untersuchern. Die damit vereinfachte Dosimetrie mit nur einer Messung nach 120 Stunden unter Verwendung der NLME-Methode zeigt, dass diese akzeptabel ist und genaue Werte für die Schilddrüsentherapie mit 131I liefert.
The cooperation of the Ulm Group for Medical Radiation Physics with the Department of Medical Physics and Biophysics of Universitas Indonesia was awarded the "International Best Abstract Award for Indonesia" for its contribution to the annual meeting of the Society for Nuclear Medicine and Molecular Imaging (SNMMI).
In molecular radiotherapy, individual determination of time-integrated activities is needed. The aim of this study was to develop an optimised, more reproducible method combining "non-linear mixed-effects" (NLME) modeling with population-based model selection (PBMS) for accurate determination of time-integrated activities. The technique was demonstrated using renal dosimetry in 177Lu-PSMA therapy as an example.
D. Hardiansyah, A. Riana, M. Eiber, A. J. Beer, G. Glatting, " Improving the accuracy of the time-integrated activity using non-linear mixed-effects modeling and population-based model selection in molecular radiotherapy," J Nuc Med 64, P519 (2023).
The cooperation of the Ulm Group for Medical Radiation Physics with the Department of Medical Physics and Biophysics of Universitas Indonesia was awarded the "International Best Abstract Award for Indonesia" for its contribution to the annual meeting of the Society for Nuclear Medicine and Molecular Imaging (SNMMI).
The award-winning contribution explores ways to individualise nuclear medicine therapy using prior knowledge about the patient population.
D. Hardiansyah, A. Riana, P. Kletting, N. Zaid, A. Beer, G. Glatting, "Model Selection Based on Population Fitting at an Example of 177Lu-PSMA Kinetics in Kidneys with a Low Number of Data," J Nuc Med 62, 1435-1435 (2021).
Calculating the optimal tumor therapy
Award: Medical physicist Dr. Peter Kletting from Ulm receives the Science Award of the German Society for Medical Physics
The German Society for Medical Physics (DGMP) has awarded Dr. biol. hum. Peter Kletting, medical physicist at the Department of Nuclear Medicine at Ulm University Hospital, with the Science Award 2020 for his research on targeted irradiation of tumor tissue with radioactively labeled peptides.
You can read a detailed description of the research work here.
(Only in german language)
Nusrat Begum, PhD student in the Department of Nuclear Medicine, was honored with the 2019 Alavi Mandell Award.
Nusrat Jihan Begum, MSc, PhD student in the Department of Nuclear Medicine at Ulm University Hospital has been awarded the American Alavi-Mandell Prize for her publication in The Journal of Nuclear Medicine (JNM, impact factor 7.4 (2017)).
The prize was awarded for her publication entitled
( “The effect of total tumor volume on the biologically effective dose of tumor and kidneys for 177Lu-labelled PSMA peptides”).
Publication by Dr. Peter Kletting, Department of Nuclear Medicine at Ulm University Hospital, was awarded a prize by the German Society of Nuclear Medicine (DGN).
For his achievements in the field of nuclear medicine therapy, Dr. biol. hum. Peter Kletting, a member of staff at the Clinic for Nuclear Medicine | Medical Radiation Physics at Ulm University Hospital, has received this year's sponsorship award from the German Society for Nuclear Medicine (DGN). The award is endowed with 3,000 euros. The prize of the professional society is intended to honor scientific publications that make an outstanding contribution to the establishment or optimization of nuclear medicine therapies. For more information, please see the press release.
(Only in german language)
Dr. biol. hum. Peter Kletting (Ulm) has received one of the 3 Behnken-Berger Prizes 2017 for the development of a method to improve the therapeutic index for radioligand therapy. (Publication)
The award ceremony took place during the joint Annual Meeting of Biomedical Engineering and the Three-Country Meeting of Medical Physics in Dresden on September 11, 2017.
The awarded paper by Dr. Peter Kletting describes a method by the application of which the therapeutic index for radioligand therapy can be improved.
With the help of the physiologically based pharmacokinetic model developed by Dr. Kletting and the simulation algorithm, the combination of activity and amount of peptide used can be determined individually for each patient, leading to the optimal ratio of biologically effective dose in the tumor to organs at risk. As a result, the effectiveness of the therapy is increased while the radiation exposure remains the same, or the radiation exposure to the organs at risk can be minimized for a given effect. The developed method can be transferred to other substances and thus shows an extraordinary relevance for current and future therapy concepts. Therefore, they represent an important step in reducing the radiation exposure of patients. This outstanding work is closely related to the work published by Dr. Kletting so far in the field of therapeutic use with ionizing radiation.
The Ulm and Mannheim Medical Radiation Physics Group were awarded the "International Best Abstract Award" for their contribution to the annual meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) in Denver, Colorado.
The award-winning paper explores ways to individualize nuclear medicine therapy. The results of the research have already been published.
By: Petra Schultze
Ulm medical physicists Dr. Peter Kletting and Prof. Dr. Gerhard Glatting of the University Department of Nuclear Medicine receive the prize for the best scientific article in the Journal of Medical Physics 2015.
The German Society of Nuclear Medicine honours young scientist Peter Kletting from the Department of Nuclear Medicine with the Covidien Nuclear Medicine Award. [more]
By: Jörg Portius
Medical physicist Prof. Dr Glatting is honoured for his research by the German Society for Medical Physics on 13 September
The German Society for Medical Phys ics (DGMP) is honouring Ulm medical physicist Prof. Dr. Gerhard Glatting for his research into the targeted irradiation of tumour tissue with radioactively labelled antibodies in cancer patients. [more]
Contact us
Address
University Hospital Ulm
Nuclear Medicine
Chair of Medical Radiation Physics
Albert-Einstein-Allee 23
89081 Ulm, Germany
You reach us by phone:
Mon to Th: 08:00 - 12:00 and 13:00 - 17:00
Fr: 08:00 - 12:00 and 13:00 - 15:00