Publikationen Prof. Dr. Martin Wagner

Originalarbeiten
  • Russel R., Perkhofer L., Liebau S. Lin Q., Lechel A., Feld FM., Hessmann E., Gaedcke J., Güthle, M., Zenke M., Hartmann D., von Figura G., Weissinger SE., Rudolph KL., Lennerz JK., Seufferlein TS., Wagner M., Kleger A.. Loss of ataxia telangiectasia-mutated accerlerates pancreatic cacner formation and epithelial-mesenchymal transition. NatureCom, accepted 29th July 2015, (gemeinsame Letztautorenschaft)
  • Müller M, Seufferlein T, Perkhofer L, Wagner M, Kleger A. Self-Expandable Metal Stents for Persisting Esophageal Variceal Bleeding after Band Ligation or Injection-Therapy: A Retrospective Study. PLoS One. 2015 Jun 22;10(6):e0126525 (gemeinsame Letztautorenschaft)
  • Rathmayer M, Scheffer H, Braun M, Heinlein W, Akoglu B, Brechmann T, Gölder SK, Lankisch T, Messmann H, Schneider A, Wagner M, Fleßa S, Meier A, Lewerenz B, Gossner L, Faiss S, Toermer T, Werner T, Wilke MH, Lerch MM, Schepp W; DRG-Arbeitsgruppe und das Zeiterfassungsprojekt der DGVS (Autoren im Anhang). Z Gastroenterol. 2015 Mar;53(3):183-98.
  • Groneberg D, Zizer E, Lies B, Seidler B, Saur D, Wagner M, Friebe A. Dominant role of interstitial cells of Cajal in nitrergic relaxation of murine lower oesophageal sphincter. J Physiol. 2014 Nov 10. [Epub ahead of print]
  • Salem HH, Trojanowski B, Fiedler K, Maier HJ, Schirmbeck R, Wagner M, Boehm BO, Wirth T,  Baumann B. Long-term IKK2/NF-κB signaling in pancreatic β-cells induces immune-mediated diabetes. Diabetes. 2014 Mar;63(3):960-75
  • Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.
  • Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice. Gastroenterology. 2014 Aug 12. pii: S0016-5085(14)00983-4.
  • Wögenstein KL, Szabo S, Lunova M, Wiche G, Haybaeck J, Strnad P, Boor P, Wagner M, Fuchs P. Epiplakin deficiency aggravates murine caerulein-induced acute pancreatitis and favors the formation of acinar keratin granules. PLoS One. 2014 Sep 18;9, (gemeinsame Letztautorenschaft)
  • Salem HH, Trojanowski B, Fiedler K, Maier HJ, Schirmbeck R, Wagner M, Boehm BO, Wirth T, Baumann B Long-term IKK2/NF-κB signaling in pancreatic β-cells induces immune-mediated diabetes. Diabetes 63: 960-75 (2014)
  • Lunova M, Zizer E, Kucukoglu O, Schwarz C, Dillmann WH, Wagner M, Strnad P. Hsp72 overexpression accelerates the recovery from caerulein-induced pancreatitis. PLoS One. 7(7):e39972. (2012)
  • Maier HJ, Wagner M, Schips TG, Salem HH, Baumann B, Wirth T.; Requirement of NEMO/IKKγ for effective expansion of KRAS-induced precancerous lesions in the pancreas. Oncogene 2012 Jul 2. doi: 10.1038/onc.2012.272.
  • Guido von Figura, Martin Wagner, Kodandaramireddy Nalapareddy, Daniel Hartmann, Alexander Kleger, Luis Miguel Guachalla, Harshvardhan Rolyan, Guido Adler, Karl Lenhard Rudolph. Regeneration of the exocrine pancreas is delayed in telomere- dysfunctional mice. PLoS ONE 6(2):e17122. (2011)
  • Zizer E, Beilke S, Bäuerle T, Schilling K, Möhnle U, Adler G, Fischer KD, Wagner M. Loss of lsc/p115-protein leads to neuronal hypoplasia in the esophagus and an achalasia-like phenotype in mice. Gastroenterology. 139(4):1344-54 (2010)
  • Juchems M, Römpp A, Kestler HA, Ernst A, Brambs HJ, Adler G, Aschoff A, Wagner M. A prospective comparison of video colonoscopy and CT colonography in asymptomatic patients screened for colorectal cancer]. Dtsch Med Wochenschr. 135(34-35):1656-61. (2010)
  • Beilke S, Oswald F, Genze F, Wirth T, Adler G, Wagner M. The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice. Oncogene 29(28):4058-67. (2010)
  • Lorenz R, Aleksic T, Wagner M, Adler G, Weber CK. The cAMP/Epac1/Rap1 pathway in pancreatic carcinoma. Pancreas. 37(1):102-3. (2008)
  • Wagner M, Koschnick S, Beilke S, Frey M, Adler G, Schmid RM. Selective expansion of the beta-cell compartment in the pancreas of keratinocyte growth factor transgenic mice. Am J Physiol Gastrointest Liver Physiol. 294(5):G1139-47. (2008)
  • Neesse A, Wagner M, Ellenrieder V, Bachem M, Gress TM, Buchholz M. Pancreatic stellate cells potentiate proinvasive effects of SERPINE2 expression in pancreatic cancer xenograft tumors. Pancreatology 7:380-5. (2007)
  • Ripka S, Konig A, Buchholz M, Wagner M, Sipos B, Kloppel G, Downward J, Gress T, Michl P. WNT5A—target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer. Carcinogenesis 28:1178-87. (2007)
  • Wagner M, Baumann B, Aleksic T, vWichert G., Weber CK, Adler G and Wirth T. Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo. J Clin Invest. 117:1502-13. (2007)
  • Hanna Algül, Martin Wagner, Roland M. Schmid. Overexpression of ErbB2 in the exocrine pancreas induces an inflammatory response but no increased proliferation. Int J Cancer 121: 1410-16. (2007)
  • Mario Corvaro, Claudia Fuoco, Francesco Cecconi, Martin Wagner. Analysis of apoptosome dysregulation in pancreatic cancer and of its role in chemoresistance. CanBiolTher 6: 209-17. (2007)
  • Buck A, Buchholz M, Wagner M, Adler G, Gress T, Ellenrieder V. The Tumor Suppressor KLF11 Mediates a Novel Mechanism in Transforming Growth Factor {beta}-Induced Growth Inhibition That Is Inactivated in Pancreatic Cancer. Mol Cancer Res. 4:861-872 (2006)
  • Buchholz M, Schatz A, Wagner M, Michl P, Linhart T, Adler G, Gress TM, Ellenrieder V.. Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca(2+)/calcineurin signaling pathway. EMBO J. 25:3714-24 (2006)
  • Jungert K, Buck A, Buchholz M, Wagner M, Adler G, Gress TM, Ellenrieder V.. Smad-Sp1 complexes mediate TGF{beta}-induced early transcription of oncogenic Smad7 in pancreatic cancer cells. Carcinogenesis 27:2392-401 (2006)
  • Tamara Aleksic, Bernd Baumann, Martin Wagner, Guido Adler, Thomas Wirth, and Christoph K Weber. Cellular immune Reaction in the Pancreas is induced by constitutively active IKK2. Gut 56:227-36 (2007)
  • Michl P, Ramjaun AR, Pardo OE, Warne PH, Wagner M, Poulsom R, D’Arrigo C, Ryder K, Menke A, Gress T, Downward J.. CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Cancer Cell. 7:521-32 (2005)
  • I. Girkontaite, V. Sakk, M. Wagner, T. Borggrefe, K. Tedford, J. Chun, and K.-D. Fischer. The Sphingosine-1-Phosphate (S1P) Lysophospholipid Receptor S1P3 Regulates MAdCAM-1+ Endothelial Cells in Splenic Marginal Sinus Organization. J. Exp. Med. 200: 1491 – 1501 (2004).
  • M. Buchholz, A. Biebl, A. Neeße, M. Wagner, T. Iwamura, G. Leder, G. Adler, T.M. Gress. SERPINE2 (Protease Nexin I) Promotes Extracellular Matrix Production and Local Invasion of Pancreatic Tumors In Vivo. Cancer Res 63:4945-4951 (2003)
  • M. Wagner, S. Kunsch, D. Dürschmied, M. Beil, G. Adler, F. Müller, T.M. Gress. Transgenic overexpression of the oncofetal RNA binding protein KOC leads to emodeling of the exocrine pancreas. Gastroenterology: 124, 1901-14 (2003)
  • S. Liptay, C.K. Weber, L. Ludwig, M. Wagner, G. Adler, R.M. Schmid. Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancer. Int J Cancer 105:735-46 (2003)
  • M. Wagner, U. Seitz, B. Neumaier, S. Schultheiß, M. Bangerter, M. Bommer, F. Leithäuser, E. Wawra, G. Munzert, S.N. Reske. 3´-[18F]Fluoro-3´-deoxythymidine ([18F]-FLT) as PET tracer for imaging proliferation in a murine B-cell lymphoma model and in the human disease. Cancer Res 63: 2681-2687 (2003)
  • P. Blyszczuk, J. Czyz, G. Kania, M. Wagner, U. Roll, L. St-Onge, A.M. Wobus. Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells. Proc Natl Acad Sci 100: 998-1003 (2003)
  • M. Wagner, C.K. Weber, F. Bressau, F.R. Greten, V. Stagge, M. Ebert, S.D. Leach, G. Adler, R.M. Schmid. Transgenic overexpression of amphiregulin induces a mitogenic response selectively in pancreatic duct cells. Gastroenterology 122: 1898-912 (2002)
  • F.R. Greten, C.K. Weber, T.F. Greten, G. Schneider, M. Wagner, G. Adler, R.M. Schmid. Stat3 and NF-kappaB activation prevents apoptosis in pancreatic carcinogenesis. Gastroenterology 123:2052-63 (2002)
  • U. Seitz, M. Wagner, B. Neumaier, E. Wawra, G. Glatting, G. Leder, R.M. Schmid, S.N. Reske. Evaluation of pyrimidine emodelingg enzymes and in vitro uptake of3’-[18F]fluoro-3’-deoxythymidine ([18F]FLT) in pancreatic cancer cell lines. Eur J Nucl Med Mol Imaging 29: 1174-81 (2002)
  • W. Antonin, M. Wagner, D. Riedel, N. Brose, R. Jahn. Loss of the zymogen granule protein syncollin affects pancreatic protein synthesis and transport but not secretion. Mol Cell Biol 22: 1545-54 (2002)
  • M. Wagner, F.R. Greten, C.K. Weber, S. Koschnick, T. Mattfeld, W. Deppert, H. Kern, G. Adler, R.M. Schmid. A tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease. Genes Dev 15:286-93 (2001)
  • M. Wagner U. Seitz, T.A. Vogg, G. Glatting, B. Neumaier, F.R. Greten, R.M. Schmid, S.N.Reske.In vivo evaluation of 5-[18F]Fluoro-2’-deoxyuridine as tracer for positron emission tomography in a murine pancreatic cancer model. Cancer Res 61: 3853-7 (2001)
  • R. Vogelmann, D. Ruf, M. Wagner, G. Adler, A. Menke. Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGFb1 transgenic mouse model. Am J Physiol. 280: G164-G172 (2001)
  • L. Ludwig, H. Kessler, M. Wagner, C. Hoang-Vu, H. Dralle, G. Adler, B.O. Böhm, R.M. Schmid. Nuclear factor-kappaB is constitutively active in c-cell carcinoma and required for ret-induced transformation. Cancer Res. 61: 4526-35 (2001)
  • V. Ellenrieder, B. Alber, U. Lacher, S. Hendler, A. Menke, W. Böck, M. Wagner, M. Wilda, H. Friess, M. Büchler, G. Adler, T. Gress. Role of MT-MMPs and MMP-2 in pancreatic cancer progression. Int J Cancer 85: 14-20 (2000)
  • M. Schwarz, F. Cecconi, G. Bernier, N. Andrejewski, B. Kammandel, M. Wagner, P. Gruss. Spatial specification of mammalian eye territories by reciprocal transcriptional repression of Pax2 and Pax6. Development 127: 4325-4334 (2000)
  • R.M. Schmid, G. Klöppel, G. Adler, M. Wagner. Acinar-ductal-carcinoma sequence in transforming growth factor-alpha transgenic mice. Ann N Y Acad Sci 880:219-30 (1999)
  • Y. Tando, H. Algül, M. Wagner, H. Weidenbach, G. Adler, R.M. Schmid. Caerulein-induced NF-kappaB/Rel activation requires both Ca(2+) and protein kinase C as messengers. Am J Physiol 277: G678-G686 (1999)
  • M.P. Ebert, J. Hoffmann, C. Häckel, K. Rutkowski, R.M. Schmid, M. Wagner, G. Adler, H.U. Schulz, A. Rössner, W. Hoffmann, P. Malfertheiner. Induction of TFF1 gene expression in pancreas overexpressing transforming growth factor alpha. Gut 45:105-111 (1999)
  • A.U. Steinle, H. Weidenbach, M. Wagner, G. Adler, R.M. Schmid. NF-kappaB/Rel activation in cerulein pancreatitis. Gastroenterology 116:420-30 (1999)
  • M. Wagner
  • , H. Lührs, G. Klöppel, G. Adler, R.M. Schmid. Malignant transformation of duct-like cells originating from acini in transforming growth factor a transgenic mice. Gastroenterology 115:1254-62 (1998)
  • R.W. Grunewald, M. Wagner, I. Schubert, H.E. Franz, G.A. Müller, J. Steffgen. Rat renal expression of mRNA coding for aldose reductase and sorbitol dehydrogenase and its osmotic regulation in inner medullary collecting duct cells. Cell Physiol Biochem 8:293-303 (1998)
Übersichtsarbeiten
  • M. Wagner, Ersetzt die CT-Kolonographie die diagnostische Koloskopie? Gastro up to date (2008)
  • L. St-Onge und M. Wagner. Regulation der Entwicklung des Pankreas. In D. Ganten, K. Ruckpaul (ed.) "Molekularmedizinische Grundlagen von para- und autokrinen Regulationsstörungen", (pp25-57), Springerverlag Berlin (2006)
  • M. Wagner, G. Adler, T. Seufferlein. Kolorektale Karzinome: Neue Entwicklungen in der Tumorprävention und in der Diagnostik der Tumorausbreitung. Chir.Gastroenterol. 21:109-116　 (2005)
  • F.R. Greten, M. Wagner, C.K. Weber, U. Zechner, G. Adler, R.M. Schmid. TGF alpha transgenic mice. A model of pancreatic cancer development. Pancreatology 1: 363-368 (2001)
  • T.M. Gress, A. Menke, M. Bachem, F. Müller-Pillasch, V. Ellenrieder, H. Weidenbach, M. Wagner, G. Adler. Role of extracellular matrix in pancreatic diseases. Digestion 59:625-37 (1998)
Fallberichte

  • Kleger A, Schnell J, Essig A, Wagner M, Bommer M, Seufferlein T, Härter G Fecal transplant in refractory Clostridium difficile colitis. Dtsch Arztebl Int. 110: 108-115 (2013)

  • Stephani J, Wagner M, Breining T, Klaus J, Niess J.-H. Metabolic Alkalosis, Acute Renal Failure and Epileptic Seizures as Unusual Manifestations of an Upside-Down Stomach. Case Rep Gastroenterol 6:452-458. (2012)

  • von Figura G, Stephani J, Wagner M, Wegener M, Wolf C, Adler G, Kulaksiz H. Secondary sclerosing cholangitis after chemotherapy with bevacizumab and paclitaxel. Endoscopy 41 Suppl 2:E153-4. (2009)

  • Juchems MS, Niess JH, Leder G, Barth TF, Adler G, Brambs HJ, Wagner M. Strongyloides stercoralis: a rare cause of obstructive duodenal stenosis. Digestion 77:141-4. (2008)