Below you will find a list of our clinical trials. If you are interested in taking part in one of the trials with ongoing recruitment, please contact our Central Appointments/Registration Office.
- Current studies with ongoing recruitment
- Current studies with ongoing follow-up examinations
- Completed studies
Title: Interaction of provisional and definitive prosthetic materials for implant superstructures with the peri-implant soft tissue (study section 1) and long-term outcome of implant-supported, monolithic zirconia crowns (study section 2): Prospective, randomised pilot study
Status:Recruitment ongoing
Title: ReversFix technology: Non-destructive removal of orthodontic brackets and dental restorations - MPG study
Status:Recruitment ongoing
Title: Cost-benefit analysis of tooth preservation vs. implant therapy of decayed teeth: multicentre, prospective, randomised pilot study
Status: Recruitment completed (Ulm study centre), recruitment completed at the Stahnsdorf study centre
Title: Molecular biological and histological investigation (study phase 1) / long-term stability of lithium disilicate ceramic abutment crowns (study phase 2). Prospective, randomised pilot study.
Status:Recruitment ongoing
Kuhn K, Rudolph H, Graf M, Moldan M, Zhou S, Udart M, Böhmler A, Luthardt RG.
Interaction of titanium, zirconia and lithium disilicate with peri-implant soft tissue: study protocol for a randomised controlled trial.
Trials. 2015 Oct 15;16:467. doi: 10.1186/s13063-015-0979-4.
Title: Long-term success of implants and their prosthetic restoration in single-tooth gaps in the posterior region as a function of the material selected for the hybrid abutment crowns. A randomised controlled clinical study (iSy).
Status:Recruitment ongoing (Hilzingen study centre)
Title: Single dental implant retained mandibular complete dentures - influence of the loading protocol
[Single dental implant retained mandibular complete dentures - influence of the loading protocol]
Status: Recruitment completed, follow-up studies ongoing
Schwindling FS, Raedel M, Passia N, Freitag-Wolf S, Wolfart S, Att W, Mundt T, Reissmann D, Ismail F, von Königsmark V, Kern M.
The single mandibular implant study - Short-term effects of the loading protocol on Oral Health-related Quality of Life.
J Prosthodont Res. 2018 Jul;62(3):313-316. doi: 10.1016/j.jpor.2017.12.003. Epub 2018 May 7.
Kern M, Att W, Fritzer E, Kappel S, Luthardt RG, Mundt T, Reissmann DR, Rädel M, Stiesch M, Wolfart S, Passia N.
Survival and Complications of Single Dental Implants in the Edentulous Mandible Following Immediate or Delayed Loading: A Randomised Controlled Clinical Trial.
J Dent Res. 2018 Feb;97(2):163-170. doi: 10.1177/0022034517736063. Epub 2017 Oct 18.
Passia N, Abou-Ayash S, Reissmann DR, Fritzer E, Kappel S, Konstantinidis I, Königsmarck VV, Mundt T, Stiesch M, Wolfart S, Ali S, Kern M.
Single mandibular implant study (SMIS) - masticatory performance - results from a randomised clinical trial using two different loading protocols.
J Dent. 2017 Oct;65:64-69. doi: 10.1016/j.jdent.2017.07.005. Epub 2017 Jul 10.
Mundt T, Passia N, Att W, Heydecke G, Freitag-Wolf S, Luthardt RG, Kappel S, Konstantinidis IK, Stiesch M, Wolfart S, Kern M.
Pain and discomfort following immediate and delayed loading by overdentures in the single mandibular implant study (SMIS).
Clin Oral Investig. 2017 Mar;21(2):635-642. doi: 10.1007/s00784-016-1930-0. Epub 2016 Aug 12.
Passia N, Att W, Freitag-Wolf S, Heydecke G, von Königsmark V, Freifrau von Maltzahn N, Mundt T, Rädel M, Schwindling FS, Wolfart S, Kern M.
Single mandibular implant study - denture satisfaction in the elderly.
J Oral Rehabil. 2017 Mar;44(3):213-219. doi: 10.1111/joor.12473. Epub 2017 Jan 22.
Passia N, Abou-Ayash S, Bender D, Fritzer E, Graf M, Kappel S, Konstantinidis I, Mundt T, Maltzahn NF, Wolfart S, Kern M.
Single Mandibular Implant Study: Recruitment Considerations.
Int J Prosthodont. 2017 Jan/Feb;30(1):43-46. doi: 10.11607/ijp.4975.
Title: Prospective pilot study on the follow-up of the One-Abutment-One-Time procedure with regard to the peri-implant tissue
Status: Recruitment (by invitation) completed
Title: Survival of 3D-planned and guided implants depending on pre-implantological hard and soft tissue management - a randomised controlled clinical trial
Status: Recruitment completed, follow-up examinations ongoing (Hilzingen study centre)
Title: Multicentre, randomised study of dental-prosthetic forms of therapy for the shortened dental arch (RaSDA): 8-, 10- and 15-year follow-up examination
Status: Recruitment completed, 15-year follow-up examinations ongoing
Walter MH, Dreyhaupt J, Hannak W, Wolfart S, Luthardt RG, Stark H, Pospiech P, Mundt T, Kern M, Böning KW, Wöstmann B, Scheller H, Jahn F, Reinhardt W, Strub J, Marré B, Heydecke G.
The Randomised Shortened Dental Arch Study: Tooth Loss Over 10 Years.
Int J Prosthodont. 2018 Jan/Feb;31(1):77-84. doi: 10.11607/ijp.5368.
Kern JS, Wolfart S, Hilgers RD, Marré B, Scheller H, Strub J, Böning K, Hannak W, Luthardt RG, Heydecke G, Huppertz J, Pospiech P, Wöstmann B, Stark H, Mundt T, Jahn F, Kern M, Edelhoff D, Walter MH.
The randomised shortened dental arch study: influence of two different treatments on interdental spacing over 5 years.
Clin Oral Investig. 2017 Jul;21(6):1945-1951. doi: 10.1007/s00784-016-1981-2. Epub 2016 Oct 26.
Reissmann DR, Heydecke G, Schierz O, Marré B, Wolfart S, Strub JR, Stark H, Pospiech P, Mundt T, Hannak W, Hartmann S, Wöstmann B, Luthardt RG, Böning KW, Kern M, Walter MH.
The randomised shortened dental arch study: temporomandibular disorder pain.
Clin Oral Investig. 2014 Dec;18(9):2159-69. doi: 10.1007/s00784-014-1188-3. Epub 2014 Jan 23.
Walter MH, Marré B, Vach K, Strub J, Mundt T, Stark H, Pospiech P, Wöstmann B, Heydecke G, Kern M, Hartmann S, Luthardt R, Huppertz J, Wolfart S, Hannak W.
Management of shortened dental arches and periodontal health: 5-year results of a randomised trial.
J Oral Rehabil. 2014 Jul;41(7):515-22. doi: 10.1111/joor.12160. Epub 2014 Mar 27.
Wolfart S, Müller F, Gerß J, Heyedcke G, Marré B, Böning K, Wöstmann B, Kern M, Mundt T, Hannak W, Brückner J, Passia N, Jahn F, Hartmann S, Stark H, Richter EJ, Gernet W, Luthardt RG, Walter MH.
The randomised shortened dental arch study: oral health-related quality of life.
Clin Oral Investig. 2014;18(2):525-33. doi: 10.1007/s00784-013-0991-6. Epub 2013 May 17.
Walter MH, Hannak W, Kern M, Mundt T, Gernet W, Weber A, Wöstmann B, Stark H, Werner D, Hartmann S, Range U, Jahn F, Passia N, Pospiech P, Mitov G, Brückner J, Wolfart S, Busche E, Luthardt RG, Heydecke G, Marré B.
The randomised shortened dental arch study: tooth loss over five years.
Clin Oral Investig. 2013 Apr;17(3):877-86. doi: 10.1007/s00784-012-0761-x. Epub 2012 Jun 26.
Wolfart S, Marré B, Wöstmann B, Kern M, Mundt T, Luthardt RG, Huppertz J, Hannak W, Reiber T, Passia N, Heydecke G, Reinhardt W, Hartmann S, Busche E, Mitov G, Stark H, Pospiech P, Weber A, Gernet W, Walter MH.
The randomised shortened dental arch study: 5-year maintenance.
J Dent Res. 2012 Jul;91(7 Suppl):65S-71S.
Walter MH, Weber A, Marré B, Gitt I, Gerss J, Hannak W, Hartmann S, Heydecke G, Huppertz J, Jahn F, Ludwig A, Mundt T, Kern M, Klein V, Pospiech P, Stumbaum M, Wolfart S, Wöstmann B, Busche E, Böning K, Luthardt RG.
The randomised shortened dental arch study: tooth loss.
J Dent Res. 2010 Aug;89(8):818-22. doi: 10.1177/0022034510366817. Epub 2010 Apr 16.
The Randomised Shortened Dental Arch study (RaSDA): design and protocol.
Luthardt RG, Marré B, Heinecke A, Gerss J, Aggstaller H, Busche E, Dressler P, Gitt I, Hannak W, Hartmann S, Heydecke G, Jahn F, Kern M, Mundt T, Pospiech P, Stark H, Wöstmann B, Walter MH.
Trials. 2010 Feb 19;11:15. doi: 10.1186/1745-6215-11-15.
Title:Prospective, randomised, stratified clinical trial (RCT) on the survival probability of bridges on natural teeth and implants.
Status: Recruitment completed, 5-, 7- and 10-year follow-ups ongoing
Title: Randomised controlled clinical study on bone preservation after tooth extractions with the combination material of collagen cone and collagen membrane "Sombrero" in comparison to a control group.
Status: completed (Hilzingen study centre)
Title: Clinical study on soft tissue management in impressions - Part 2
Status: completed
Title: Clinical cross-over study on soft tissue management in impressions.
Status: finalised
Title: Analysis of calprotectin, PMN-elastase, MMP-8 and IL-1ẞ in µl volumes in gingival sulcus fluid - suitability as prognostic factors of recession development in soft tissue management
Status: finalised
Analysis of calprotectin, PMN elastase, MMP-8 and IL-1β in microlitre volumes of gingival crevicular fluid - suitability as prognostic factors for the recession after soft tissue management
Medical dissertation, University of Ulm 2017
Title: Analysis of PMN-elastase, MMP-8 and IL-1β in µL volumes in gingival sulcus fluid.
Status: completed
Mock D
Master's thesis, Master's programme in Dental Prosthetics: University of Greifswald (2011)
Title: An open-label, prospective, single-arm, multicentre study to evaluate the OsseospeedTM implant (3mm diameter) as a replacement for a central or lateral mandibular incisor or a lateral maxillary incisor. A 5-year follow-up study.
Status: finalised
Galindo-Moreno P, Nilsson P, King P, Worsaae N, Schramm A, Padial-Molina M, Maiorana C.
Clinical and radiographic evaluation of early loaded narrow-diameter implants: 5-year follow-up of a multicentre prospective clinical study.
Clin Oral Implants Res. 2017 Dec;28(12):1584-1591. doi: 10.1111/clr.13029. Epub 2017 Jun 18.
Galindo-Moreno P, Padial-Molina M, Nilsson P, King P, Worsaae N, Schramm A, Maiorana C.
The influence of the distance between narrow implants and the adjacent teeth on marginal bone levels.
Clin Oral Implants Res. 2017 Jun;28(6):704-712. doi: 10.1111/clr.12867. Epub 2016 May 7.
King P, Maiorana C, Luthardt RG, Sondell K, Øland J, Galindo-Moreno P, Nilsson P.
Clinical and Radiographic Evaluation of a Small-Diameter Dental Implant Used for the Restoration of Patients with Permanent Tooth Agenesis (Hypodontia) in the Maxillary Lateral Incisor and Mandibular Incisor Regions: A 36-Month Follow-Up.
Int J Prosthodont. 2016 Mar-Apr;29(2):147-53. doi: 10.11607/ijp.4444.
Maiorana C, King P, Quaas S, Sondell K, Worsaae N, Galindo-Moreno P.
Clinical and radiographic evaluation of early loaded narrow-diameter implants: 3 years follow-up.
Clin Oral Implants Res. 2015;26(1):77-82. doi: 10.1111/clr.12281. Epub 2013 Oct 30.
Galindo-Moreno P, Nilsson P, King P, Becktor J, Speroni S, Schramm A, Maiorana C.
Clinical and radiographic evaluation of early loaded narrow diameter implants - 1-year follow-up.
Clin Oral Implants Res. 2012 May;23(5):609-16. doi: 10.1111/j.1600-0501.2011.02254.x. Epub 2011 Sep 28.