Expe­ri­men­tal Car­dio­va­s­cu­lar Ima­ging (ExCaVI)

Our group is active in the rese­arch and deve­lo­p­ment of dedi­ca­ted tech­ni­ques for in vivo magne­tic reso­nance (MR) ima­ging and spec­troscopy and their appli­ca­tion to bio­me­di­cal trans­la­tio­nal rese­arch inclu­ding pre­cli­ni­cal and cli­ni­cal eva­lua­tion. In close col­la­bo­ra­tion with dif­fe­rent part­ners within the Uni­ver­sity and the Uni­ver­sity Medi­cal Cen­ter, tail­o­red ima­ging and spec­troscopy solu­ti­ons are deve­lo­ped for a variety of pre­cli­ni­cal and cli­ni­cal appli­ca­ti­ons. Acti­vi­ties range from basic MR tech­no­lo­gies to application-​specific opti­miza­tion of the basic tech­ni­ques for rou­tine cli­ni­cal eva­lua­tion. For multi-​modal ima­ging pur­po­ses, close col­la­bo­ra­tion with the Depart­ments of Nuclear Medi­cine and Radio­logy is estab­lished.

The group also runs the Core Faci­lity Small Ani­mal Ima­ging of the Medi­cal Faculty of Ulm Uni­ver­sity and is part of the DFG fun­ded Cen­ter for Trans­la­tio­nal Ima­ging MoMAN.

Profilbild von Prof. Dr. rer. nat. Volker Rasche

Prof. Dr. rer. nat. Vol­ker Rasche

Head of Work­group

Rese­arch fields

Car­dio­va­s­cu­lar MRI

Small Ani­mal MRI

Den­tal MRI

Image-​Guided Inter­ven­ti­ons

In ovo MRI

Lung MRI

Method Deve­lo­p­ment

Infra­struc­ture

Within the Car­dio­va­s­cu­lar MRI group, two whole-​body MRI sys­tems ope­ra­ting at

  • 1.5T Phil­ips Achieva, R5.1.7, 32 receive chan­nels
  • 3.0T Phil­ips Achieva, R5.1.7, 32 receive chan­nels

are availa­ble for cli­ni­cal and metho­do­lo­gi­cal rese­arch. Both sys­tems are fully equip­ped with high-​performance gra­di­ent sys­tems, dedi­ca­ted car­dio­va­s­cu­lar ima­ging soft­ware and state-​of-the-art receive coils rele­vant for car­dio­va­s­cu­lar ima­ging such as dedi­ca­ted car­diac and caro­tid pha­sed array coils.

A Rese­arch col­la­bo­ra­tion with Phil­ips Medi­cal Sys­tems and Phil­ips Rese­arch Europe is well estab­lished ensu­ring access to latest MRI tech­no­logy and pulse pro­gramming soft­ware enab­ling the adap­tation of the scan­ner SW to indi­vi­dual demands.

A dedi­ca­ted small ani­mal high-​field MRI sys­tem (Bio­Spec 117/16, Bru­ker Bio­spin) equip­ped with an 8-​channel receive sys­tem and pre­pa­red for 1H, 13C, 19F, 23Na, and 31P ima­ging and spec­troscopy is availa­ble at the Core Faci­lity Small Ani­mal Ima­ging.

Publi­ca­ti­ons

2022

Trai­nee Edu­ca­tio­nal Sti­pend ISMRM 2022 (P. Metze, T. Spei­del)

2021

Trai­nee Edu­ca­tio­nal Sti­pend ISMRM 2021 (P. Metze, T. Spei­del)

2020

Pos­ter EMIM Vir­tual Edi­tion 2020 (G. Win­ter et al., #0581)
Multi-​modal PET and MR ima­ging in the Hen’s egg test cho­rio­al­l­an­toic mem­brane (HET-​CAM) model for initial in vivo testing of target-​specific radio­li­gands.

Magna Cum Laude Pos­ter ISMRM 2020 (P. Metze et al., #0438)
Lung Ima­ging and Pro­ton Frac­tion Quan­ti­fi­ca­tion for Highly Irre­gu­lar Respi­ra­tory Pat­terns Using non­uni­form Self-​Gating.

Summa Cum Laude Pos­ter ISMRM 2020 (T. Spei­del et al., #1087)
Retro­spec­tive Com­pen­sa­tion of Car­diac and Respi­ra­tory Motion in Mice using non­uni­form Self-​Gating.

Trai­nee Edu­ca­tio­nal Sti­pend ISMRM 2020 (A. Balasch, T. Huef­ken, P. Metze, T. Spei­del, K. Stumpf)

Towards sub-​microlitre MRS in the mouse brain in vivo at ultra-​high field. Work sel­ec­ted for the Mole­cu­lar/MRS High­light Ses­sion of ISMRM 2020 (A. Abaei et al., #0372)

Lung Ima­ging and Pro­ton Frac­tion Quan­ti­fi­ca­tion for Highly Irre­gu­lar Respi­ra­tory Pat­terns Using Non­uni­form Self-​Gating. Work sel­ec­ted for the Body High­light Ses­sion of ISMRM 2020 (P. Metze et al., #0438)

2019

Trai­nee Edu­ca­tio­nal Sti­pend ISMRM 2019 (P. Metze, T. Spei­del)

Hertha-​Nathorff-Programm (HNP) der Medi­zi­ni­schen Fakul­tät (A. Balasch, I. Ver­ni­kous­kaya)

2017

Trai­nee Edu­ca­tio­nal Sti­pend ISMRM 2017 (A. Abaei)

2016

Magna Cum Laude Pos­ter ISMRM 2016 (M. Tibi­letti et al., #2912, #2921)

Trai­nee Edu­ca­tio­nal Sti­pend ISMRM 2016 (A. Abaei, J. Paul, M. Tibi­letti, Z. Zuo)

Natio­nal Award for Out­stan­ding Self-​financed Chi­nese Stu­dents Abroad (Z. Zuo)

2015

Hertha-​Nathorff-Programm (HNP) der Medi­zi­ni­schen Fakul­tät (I. Ver­ni­kous­kaya)

Magna Cum Laude Pos­ter ISMRM 2015 (S. Wund­rak et al., #3638)

Trai­nee Edu­ca­tio­nal Sti­pend ISMRM 2015 (J. Paul, M. Tibi­letti, I. Ver­ni­kous­kaya)

Georg-​Schmorl-Award 2015 (H.-J. Wilke, A.Kienle, S. Maile, V.Rasche, N. Berger-​Roscher)

Pos­ter Award 2015 "Deut­sche Gesell­schaft für Ortho­pä­die und Unfall­chir­ur­gie" (H.-J. Wilke, A.Kienle, S. Maile, V.Rasche, N. Berger-​Roscher)

2010

Award of the Uni­ver­sity of Ulm for col­la­bo­ra­tion bet­ween aca­de­mics and indus­try (V. Rasche)

2008

Award of the Uni­ver­sity of Ulm for out­stan­ding edu­ca­tion (V. Rasche)

2022

Non-​water sup­pres­sed Car­diac Magne­tic Reso­nance Spec­troscopy
Fabian Bschorr, Mas­ter's The­sis

Effi­ci­ent Sam­pling Stra­te­gies for N-D MRI
Micha Bischoff, Mas­ter's The­sis

Eva­lua­tion of a Polar Acqui­si­tion Recon­struc­tion Tech­ni­que in MRI
Maria Con­cialdi, Bache­lor's The­sis

Con­struc­tion and Cha­rac­te­riza­tion of an active Phan­tom for simul­ta­neous Dif­fu­sion weigh­ted PET-​MRI in Onco­logy
Leo­nard Lau­ber, Bache­lor's The­sis

2021

Design and Spa­tial Enco­ding Field Simu­la­ti­ons for a low-​Field MRI Scan­ner
Chris­tos Papa­do­pou­los, Bache­lor's The­sis

Image Recon­struc­tion for inho­mo­ge­neous Spa­tial Enco­ding Fields in a low-​Field MRI Scan­ner
Andre Schulz-​Harder, Bache­lor's The­sis

Cha­rac­te­riza­tion of 29Si Nano­par­ticles using NMR
Sophie Stolte, Bache­lor's The­sis

High-​Resolution MRI of the Adult Zebra­fish Heart
Julian Schüle, Bache­lor's The­sis

Deve­lo­p­ment of a GUI for the Recon­struc­tion of radi­ally acqui­red MRI Data­sets
Johan­nes Mokosch, Bache­lor's The­sis

Fat-​water quan­ti­fi­ca­tion using multi-​point Dixon methods 
Ste­ven Roth, Bache­lor's The­sis

Exami­na­tion of acce­le­ra­tion methods for dif­fu­sion weigh­ted ima­ging 
Rauf Hood Bou­denne, Bache­lor's The­sis

Deep Lear­ning Approa­ches for Nuclear Magne­tic Reso­nance Spec­troscopy 
Oleg Wino­kurow, Bache­lor's The­sis

2020

Towards Quan­ti­fi­ca­tion of IMCL/EMCL in a Human Mus­cle with Nuclear Magne­tic Reso­nance 
Fabian Bschorr, Bache­lor's The­sis

Lung MRI Ising a Non-​Uniform Self-​Gating Approach 
Fabian Straub­mül­ler, Mas­ter's The­sis

BURST MRI
Domi­nik Zeck, Mas­ter's The­sis

Lon­gi­tu­di­nal Eva­lua­tion of DSS-​induced Murine Ulce­ra­tive Coli­tis In vivo
Eric Karuu, Dis­ser­ta­tion

Simu­la­tion and Pro­to­typ­ing of an X-​Nuclei MR Coil
Andreas Horn­eff, Dis­ser­ta­tion

Real-​Time Car­dio­va­s­cu­lar Flow Magne­tic Reso­nance Ima­ging
Domi­nik Notz, Mas­ter's The­sis

Myo­car­dial T1 map­ping at 11.7T
Micha Bischoff, Bache­lor's The­sis

Real-​time magne­tic reso­nance ima­ging of the tem­poro­man­di­bu­lar joint
Johan­nes Zieg­ler, Bache­lor's The­sis

2019

Opti­miza­tion and cha­rac­te­riza­tion of a bipla­nar gra­di­ent sys­tem for microscopic MR-​imaging at 11.7T
Lukas Staiger, Bache­lor's The­sis

Real-​time car­diac MRI at 11.7T
Mar­ga­reta Metz­ner, Bache­lor's The­sis

Con­vo­lu­tio­nal Neu­ral Net­works (CNN) Applied to Respi­ra­tory Motion Detec­tion in Fluo­roscopic Frames
Chris­toph Bal­d­auf, Mas­ter's The­sis

2018

Real-​time MRI of spea­king: an approach on off-​resonance cor­rec­tion
Mar­kus Jakob, Bache­lor's The­sis

Imple­men­ta­tion of gra­di­ent Impulse Response Mea­su­re­ment on a 3T MRI scan­ner for Gra­di­ent Sys­tem Cha­rac­te­riza­tion
Anja Klee­mann, Mas­ter's The­sis

Real-​time MRI for Car­dio­va­s­cu­lar Appli­ca­ti­ons
Clau­dia Lumpp, Mas­ter's The­sis

Deve­lo­p­ment and cha­rac­te­riza­tion of a microscopy insert for high-​field MR sys­tems
Tho­mas Hüf­ken, Mas­ter's The­sis

2017

Car­dio­va­s­cu­lar Tis­sue Cha­rac­te­riza­tion with MRI
Patrick Metze, Mas­ter's The­sis

Model-​based ite­ra­tive Recon­struc­tion for Dif­fu­sion Quan­ti­fi­ca­tion
Jan­nik Arbo­gast, Mas­ter's The­sis

Ana­to­mical and func­tio­nal lung ima­ging with MRI
Marta Tibi­letti, Dis­ser­ta­tion

Dar­stel­lung api­ka­ler Par­odon­ti­tis ver­glei­chend in der Magnet­re­so­nanz­to­mo­gra­phie und in der digi­ta­len Volu­men­to­mo­gra­phie
Elena Sophia Schrei­ber, Dis­ser­ta­tion

2016

Advan­ced SPI Methods for MR Ima­ging of ultras­hort T2(*) Rela­xa­tion Time Spin Sys­tems
Tobias Spei­del, Mas­ter's The­sis

Tiny Gol­den Angles and Non­uni­form Self-​Gating: MRI of Nonuni­gorm Motion
Ste­fan Wund­rak, Dis­ser­ta­tion

Ana­ly­sis of velo­city based motion para­me­ters in vol­un­teers and pati­ents with left ven­tri­cu­lur dys­syn­chrony and myo­car­dial infarc­tion using magne­tic reso­nance ima­ging
Raphael Beck, Dis­ser­ta­tion

Den­tal MRI for Iden­ti­fi­ca­tion and Quan­ti­fi­ca­tion of Initial Caries Lesi­ons
Anna-​Katinka Bra­cher, Dis­ser­ta­tion

Respi­ra­tory and Car­diac Self-​Gated Radial MRI
Jan Paul, Dis­ser­ta­tion

Ent­wick­lung eines MRT-​Phantoms mit T1/T2-​Relaxationszeiten im Bereich des mensch­li­chen Gewe­bes
Chris­toph Blank, Bache­lor's The­sis

2015

High reso­lu­tion MRI ana­ly­sis of breast can­cer xeno­graft on the chick cho­rio­al­l­an­toic mem­brane
Zhi Zuo, Dis­ser­ta­tion

Qua­li­ta­tive and Quan­ti­ta­tive Assess­ment of the Local Con­trast Agent Aggre­ga­ti­ons using MRI
Ina Ver­ni­kous­kaya, Dis­ser­ta­tion

Opti­mie­rung der MRT-​Bildrekonstruktion von radial gemes­se­nen Echt­zeit­da­ten in MAT­LAB und CUDA.
Harald Frey, Mas­ter's The­sis

2014

Die Com­pli­ance der Aorta nach endo­vas­ku­lä­rer Ver­sor­gung bei aku­ter trau­ma­ti­scher Aor­ten­rap­tur
Robert Kohl­schmitt, Dis­ser­ta­tion

Appli­ka­tion der Magnet­re­so­nanz­to­mo­gra­phie für zahn­me­di­zi­ni­sche Fra­ge­stel­lun­gen
Michael Mess, Dis­ser­ta­tion

Appli­ca­bi­lity of three-​dimensional ultra-​short echo time magne­tic reso­nance ima­ging for in vivo assess­ment of caries lesi­ons and early demi­ne­ra­liza­tion.
Chris­tian Hof­mann, Dis­ser­ta­tion

2013

Volu­metric left ven­tri­cu­lar tis­sue phase map­ping at 3T - Sequence opti­miza­tion and motion quan­ti­fi­ca­tion
Anja Müller-​Lutz, Dis­ser­ta­tion

2012

Gra­di­en­ten­feld­mes­sung eines 3Tesla Magnet­re­so­nanz­to­mo­gra­phen
Michael Eder, Dipl. Ing.

Berech­nung und Ana­lyse von Para­me­tern zur Quan­ti­fi­zie­rung der Asyn­chro­ni­tät des Herz­schla­ges aus geschwin­dig­keits­co­dier­ten MRT-​Aufnahmen
Jan Paul, Dipl. Inf.

2011

T2-​Prepared Seg­men­ted 3D Gra­di­ent Echo for Fast T2-​Weighted High Reso­lu­tion Three-​Dimensional Ima­ging of the Caro­tid Artery Wall
Jian Zhu, Dr. med.

2010

Auto­ma­ti­sche Ver­fol­gung von Abla­ti­ons­ka­the­tern in 3D
Diana Adam, M. Sc.
in Zusam­men­ar­beit mit der Hosch­schule Ulm, Fakul­tät Inform­tik, Prof. Harald Groß

Rekon­struk­tion von unter­ab­ge­tas­te­ten MRI Daten­sät­zen, akqui­riert auf belie­bi­gen Abtast­git­tern
Chris­tine Köhn­lein, Dipl. Phys.

Pro­jek­ti­ons­re­kon­struk­ti­ons­me­tho­den für die fluo­ro­sko­pi­sche MRT unter Ver­wen­dung der "Gol­de­nen Schnitt" Geo­me­trie
Anna-​Lena Bra­cher, Phsik B.Sc.
in Zusam­men­ar­beit mit AG Mate­ri­al­wis­senchaft­li­che Elek­tro­nen­mi­kro­sko­pie, Uni Ulm, Prof. Ute Kai­ser

Inte­gra­tion eines low-​cost Ultra­schall­sys­tems im MRT zur Detek­tion der atmungs­ab­hän­gi­gen Herz­lage
Sina Phis­ter, B.Sc.
in Zusam­men­ar­beit mit der Fakul­tät für Mecha­tro­nik und Medi­zin­tech­nik, Hoschule Ulm, Prof. Ronald Blechschmidt-​Trapp

Computer-​aided detec­tion of ves­sel wall thi­cke­ning in MRI images
Moritz Eberl, M. Sc.
in Zusam­men­ar­beit mit der Fakul­tät für Infor­ma­tik, Hoch­schule Augs­burg, Prof. Roesch

2009

MRI Stu­dies of Gado­li­nium based con­trast agents loa­ded nano­cap­su­les and iron loa­ded nano­cap­su­les in che­mi­cal and bio­lo­gi­cal envi­ron­ment
Sonu Sharma, Dr. biol.hum.

Iron Label­ling of Mesen­chy­mal Stem / Stroma Cells for MRI: Stu­dies on Poly-​L-Lactid Acid - Iron Nano­par­ticles
Ger­linde Schmidtke-​Schrezenmeier, Dr. med.
in Zusam­men­ar­beit mit der Kli­nik für Der­ma­to­lo­gie und All­er­go­lo­gie der Uni­ver­si­täts­kli­nik Ulm
Prof. Karin Scharffetter-​Kochanek

Auto­ma­tic mode­ling methods for 3D car­diac X-ray
Uwe Jandt, Dr. biol. hum.

Dia­gnos­tik der Aorten-​ und Mit­ral­klap­pen­in­suf­fi­zi­enz MRT ver­sus Echo­kar­dio­gra­phie
Pierre Yout­cheua Njin­deu, Dr. med

2008

Vier­di­men­sio­nale Mini­mie­rung von pati­en­ten­in­du­zier­ten Magnet­feldin­ho­mo­ge­ni­tä­ten für die kar­diale Magnet­re­so­nanz­to­mo­gra­phie
Miriam Rabea Kubach, Dipl. phys.
in Zusam­men­ar­beit mit der Fakul­tät für Phy­sik, Prof. Dr. G. Nien­haus

2006

Inte­gra­tion von Magnet­re­so­nanz­to­mo­gra­phie­da­ten und Roent­gen­fluo­ro­sko­pie­da­ten zur Unter­stüt­zung inter­ven­tio­nel­ler Ver­fah­ren in der Kar­dio­lo­gie
Alois Goeth, Mas­ter of Sci­ence
in Zusam­men­ar­beit mit der Fach­hoch­schule Augs­burg, Prof. Dr. Peter Roesch

Drei­di­men­sio­nale Regis­trie­rung in der Koro­nar­dia­gnos­tik
Danial Magg, Dipl. inf (FH)
in Zusam­men­ar­beit mit der Hoch­schule Ulm, Prof. Dr. Guen­ter Gram­lich

Col­la­bo­ra­tors & Spon­sors