Publications

Laboratory for Molecular Psychosomatics

2023

  • Langgartner D, Winkler R, Brunner-Weisser J, Rohleder N, Jarczok MN, Gündel H, Weimer K, Reber SO. COVID-19 vaccination exacerbates ex vivo IL-6 release from isolated PBMCs. Nature Scientific Reports in press.

  • Tschaffon-Müller MEA*, Kempter E*, Steppe L, Kupfer S, Kuhn MR, Gebhard F, Pankratz C, Kalbitz M, Schütze K, Gündel H, Kaleck N, Strauß G, Vacher J, Ichinose H, Weimer K, Ignatius A, Haffner-Luntzer M*, Reber SO*. Neutrophil-derived catecholamines mediate negative stress effects on bone. Nature Communications in press.

  • Langgartner D*, Koenen M*, Kupfer S, Glogger L, Kurz L, Perez-Rivas LG, Theodoropoulou M, Noll-Hussong M, Vettorazzi S, Tuckermann J*, Reber SO*. Intact GR dimerization is critical for restraining plasma ACTH levels during chronic psychosocial stress. Neurobiology of Stress in press

  • Holbrook EM, Zambrano CA, Wright CTO, Dubé EM, Stewart JR, Sanders WJ, Frank MG, MacDonald AS, Reber SO and Lowry CA. Mycobacterium vaccae NCTC 11659, a soil-derived bacterium with stress resilience properties, modulates the proinflammatory effects of LPS in macrophages. International Journal of Molecular Sciences in press.

  • Langgartner D*, Amoroso M*, Kempter E, Kustermann M, Scheurer J, Lowry CA, Strauß G, Reber SO. Mycobacterium vaccae protects against glucocorticoid resistance resulting from combined physical and psychosocial trauma in mice. Brain, Behavior and Immunity 109: 221-234.

  • Kempter E, Amoroso M, Kupfer S, Lupu L, Kustermann M, Scheurer J, Baumann B, Wirth T, Gündel H, Straub RH, Strauß G, Huber-Lang M, Langgartner D, Reber SO. The PMN-MDSC – a key player in glucocorticoid resistance following combined physical and psychosocial trauma. Brain, Behavior and Immunity 108: 148–161.

  • Balint EM, Daniele V, Langgartner D, Reber SO, Rothermund E, Gündel H, Von Wietersheim J, Buckley T, Jarczok MN. Heart rate variability predicts treatment outcome of short-term psychotherapy at the workplace. Psychophysiology 00:e14150.

2022

  • Kuhn MR, Haffner-Luntzer M, Kempter E, Reber SO, Ichinose H, Vacher J, Ignatius A and Tschaffon-Müller ME. Myeloid cell-derived catecholamines influence bone turnover and regeneration in mice. Frontiers in Endocrinology 13:997745.

  • Tschaffon MEA, Reber SO, Liedert A, Nandi S, Cirstea IC, Aszodi A, Ignatius A, Haffner-Luntzer M. A novel in vitro assay to study chondrocyte-to-osteoblast transdifferentiation. Endocrine 75:266-275.

2021

  • Amoroso M, Langgartner D, Lowry CA, Reber SO. Rapidly Growing Mycobacterium Species: The Long and Winding Road from Tuberculosis Vaccines to Potent Stress-Resilience Agents. Molecular Sciences in press

  • Kempter E, Amoroso M, Duffner HL, Werner AM, Langgartner D, Kupfer S, Reber SO. Changes in functional glucocorticoid sensitivity of isolated splenocytes induced by chronic stress - a time course study. Frontiers in Immunology 12:753822.

  • Balint EM, Jarczok MN, Langgartner D, Reber SO, Endes S, Schmidt-Trucksäss A, Funk A, Klinghammer J, Campbell S, Gündel H, Waller C. Heightened stress reactivity in response to an attachment related stressor in patients with medically treated primary hypertension. Frontiers in Psychiatry 12:718919.

  • Winter J, Meyer M, Berger I, Peters S, Royer M, Bianchi M, Stang S, Langgartner L,  Reber SO, Kuffner K, Schmidtner AK, Hartmann F, Bludau A, Bosch OF, Slattery DA, van den Burg EH, Jurek B, Neumann ID. Chronic oxytocin-driven alternative splicing of CRFR2α induces anxiety. Molecular Psychiatry.

  • Appiah SA, Langgarter D, Foxx CL, Palmer A, Zambrano CA, Braumuller C, Schaefer, EJ, Wachter U, Elam BL, Radermacher P, Salazar SN,  Arnold AL, Reber SO, Halbgebauer R, Lowry C, Huber- Lang M. Evaluation of the gut microbiome in association with biological signatures of inflammation in murine polytrauma and hemorrhage. Nature Scientific Reports 11(1)6665.

 

2020

  • Amoroso M, Kempter E, Langgartner D, Gross P, Reber SO. Inducing a stressed phenotype in healthy recipient mice by adoptively transferring CD4+ lymphocytes from mice undergoing chronic psychosocial stress. Psychoneuroendocrinology 122, 104898.

  • Langgartner D, Marks J, Nguyen TC, Reber SO. Changes in adrenal functioning induced by chronic psychosocial stress in male mice: a time course study. Psychoneuroendocrinology 122, 104880.

  • Langgartner D*, Zambrano CA*, Heinze JD, Stamper CE, Böbel TS, Hackl SB, Jarczok MN, Rohleder N, Rook GA, Gündel H, Waller C, Lowry CA, Reber SO. Association of the salivary microbiome with animal contact during early life and stress-induced immune activation in healthy participants. Frontiers in Psychiatry 11: Article 353.

  • Foertsch S, Langgartner D, Reber SO. Abdominal surgery prior to chronic psychosocial stress promotes spleen cell (re)activity and glucocorticoid resistance. Nature Scientific Reports 113: 169-178

  • Foertsch S & Reber SO. The role of physical trauma in social stress-induced immune activation. Neuroscience & Biobehavioral Reviews 113: 169-178 

  • Wohnhaas CT, Schmid R, Rolser M, Kaaru E, Langgartner D, Rieber K, Strobel B, Eisele C, Wiech F, Jakob I, Gantner F, Herichova I, Vinisko R, Böcher WO, Visvanathan S, Shen F, Panzenbeck M, Raymond E, Reber SO, Delić D, Baum P. Fecal microRNAs show promise as non- invasive Crohn ́s disease biomarkers. Crohns & Colitis 360_2 (1) 1-12 

  • Amoroso M,Böttcher A, Lowry CA, Langgartner D*, Reber SO*. Subcutaneous Mycobacterium vaccae promotes resilience in a mouse model of chronic psychosocial stress when administered prior to or during psychosocial stress. Brain Behavior and Immunity 87: 309- 317

  • Langgartner D, Lowry CA, Reber SO. "Old Friends", Immunregulation und Stressresilienz - Teil 1: Theoretische Grundlagen. Nervenheilkunde 39: 47-54.

  • Langgartner D, Lowry CA, Reber SO. "Old Friends", Immunregulation und Stressresilienz - Teil 2: Mechanismen. Nervenheilkunde 39: 55-66.

 

2019

  • Langgartner D, Lowry CA, Reber SO. "Old Friends", Immunregulation und Stressresilienz. Psychologische Medizin 30: 4-35.

  • Foertsch S, Lackner I, Weber B, Füchsl AM, Langgartner D, Wirkert E, Peters S, Fois G, Pressmar J, Fegert JM, Frick M, Gündel H, Gebhard F, Kalbitz M*, Reber SO*. Sensory contact to the stressor prevents recovery from structural and functional heart damage following psychosocial trauma. Brain, Behavior and Immunity 80: 667-677.

  • Amoroso M, Kempter E, Eleslambouly T, Lowry CA, Langgartner D*, Reber SO*. Intranasal Mycobacterium vaccae administration prevents stress-induced aggravation of dextran sulfate sodium (DSS) colitis. Brain, Behavior and Immunity 80: 595-604.

  • Haffner-Luntzer M*, Foertsch S*, Fischer V, Prystaz K, Tschaffon M, Mödinger Y, Bahney CS, Marcucio RS, Miclau T, Ignatius A*, Reber SO*. Chronic psychosocial stress compromises the immune response and endochondral ossification during bone fracture healing via β-AR signaling. Proc Natl Acad Sci 116(17): 8615-8622. Haffner-Luntzer M was awarded by the DGOU with the ORS Travel Award 2018 and by the ORS with the ISFR Award 2019 for presenting data reported in this manuscript.

  • Langgartner D*, Wachter U*, Hartmann C, Gröger M, Vogt J, Merz T, McCook O, Fink M, Kress S, Georgieff M, Kunze JF, Radermacher PL, Reber SO*, Wepler M*.Effects of psychosocial stress on subsequent hemorrhagic shock and resuscitation in male mice. Shock 51(6): 725-730.

  • Langgartner D, Lowry CA, Reber SO. Old Friends, immunoregulation and stress resilience. European Journal of Physiology 12(252).

2018

  • Langgartner D, Vaihinger CA, Haffner-Luntzer M, Kunze JF, Weiss ALJ, Foertsch S, Bergdolt S, Ignatius A, Reber SO. The role of the intestinal microbiome in chronic psychosocial stress-induced pathologies in male mice. Frontiers in Behavioral Neuroscience 1-33.

  • Reichel M, Rhein C, Hofmann LM, Monti J, Japtok L, Langgartner D, Füchsl AM, Kleuser B, Gulbins E, Hellerbrand C, Reber SO*, Kornhuber J*. Chronic psychosocial stress in mice is associated with increased acid sphingomyelinase activity in liver and serum and with hepatic C16:0-ceramide accumulation. Frontiers in Psychiatry 9(496).

  • Armacki M, Trugenberger AK, Ellwanger A, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Barth T, Lechel A, Kraus J, Wiegreffe C, Grimm J, Scheffield A, Schneider MR, Peuker K, Zeißig S, Rose-John S, Vettorazzi S, Wolf E, Walter B, Tannapfel A, Steinestel K, Reber SO, Walther P, Kestler H, Radermacher P, Barth TFE, Huber-Lang M, Kleger A*, Seufferlein T*. Thirty-eight-negative-kinase-1 mediates trauma-induced intestinal injury and multi-organ failure. Journal of Clinical Investigation 128(11).
  • Langgartner D, Füchsl AM, Kaiser LM, Meier T, Foertsch S, Buske C, Reber SO*, Mulaw MA*. Biomarkers for classification and class prediction of stress in a murine model of chronic subordination stress. PLoS ONE 13(9).
  • Böbel T*, Hackl S*, Langgartner D, Jarczok MN, Rohleder N, Rook GA, Lowry CA, Guendel H, Waller C, Reber SO. Less immune activation following social stress in rural vs. urban participants raised with regular or no animal contact, respectively. Proc Natl Acad Sci 115(20):5259-5264. https://doi.org/10.1073/pnas.1719866115.

  • Langgartner D*, Palmer A*, Rittlinger A, Reber SO*, Huber-Lang M*. Effects of prior psychosocial trauma on subsequent immune response after experimental thorax trauma. Shock (49)6:690–697.

 

2017

  • Foertsch S, Füchsl AM, Faller SD, Hölzer H, Langgartner D, Messmann J, Strauß G, Reber SO. Splenic glucocorticoid resistance following psychosocial stress requires physical injury. Nature Sci reports 7(1):15730.
  • Foertsch S*, Haffner-Luntzer M*, Kroner J, Gross F, Kaiser K, Erber M, Reber SO*, Ignatius A*. Chronic psychosocial stress disturbs long-bone growth in adolescent mice. Disease Models & Mechanisms 10(12):1399-1409.
  • Perani CV, Langgartner D, Uschold-Schmidt N, Füchsl AM, Neumann ID, Reber SO, Slattery DA. Adrenal gland plasticity in lactating rats and mice is sufficient to maintain basal hypersecretion of corticosterone. Stress 20(3):303-311.
  • Langgartner D, Peterlik D, Foertsch S, Füchsl AM, Brokmann P, Flor PJ, Shen Z, s G. Fox JG, Uschold-Schmidt N, Lowry CA, Reber SO. Individual differences in stress vulnerability: the role of gut pathobionts in stress-induced colitis. Brain, Behavior and Immunity 64:23-32.
  • Langgartner D, FoertschS, Füchsl AM, Reber SO. Light and water are not simple conditions: Fine tuning of animal housing in male C57BL/6 mice. Stress, 20(1):10-18.
  • Peterlik D, Stangl C, Bauer A, Bludau A, Keller J, Grabski D, Killian T, Schmidt D, Jaeschke G, Lindemann L, Reber SO, Flor PJ, Uschold-Schmidt N. Blocking Metabotropic Glutamate Receptor Subtype 5 Relieves Maladaptive Chronic Stress Consequences. Brain, Behavior & Immunity 59:79-92.

2016

  • Koch CE, Bartlang MS, Kiehn JT, Lucke L, Naujokat N, Helfrich-Förster C, Reber SO*, Oster H*. Time-of-day dependent adaptation of the HPA axis to predictable social defeat stress. Journal of Endocrinology 231:209-201.
  • Reber SO & Slattery DA. Editorial: Using stress-based animal models to understand the mechanisms underlying psychiatric and somatic disorders. Frontiers in Psychiatry 7:192.
  • Reber SO, Langgartner D, FoertschS,Postolache TT, Brenner LA, Guendel H,Lowry CA.Chronic subordinate colony housing paradigm: A mouse model for mechanisms of PTSD vulnerability, targeted prevention, and treatment—2016 Curt Richter Award Paper. Psychoneuroendocrinology 74:221-230. Reber SO was awarded by the ISPNE with the Curt P Richter Award 2016 for the research reported in this article.
  • Schmidt D, Peterlik D, Reber SO, Lechner A, Männel DN. Induction of Suppressor Cells and Increased Tumor Growth Following Chronic Psychosocial Stress in Male Mice. PLoS ONE 11(7) e0159059.
  • Lowry CA, Smith DG, Siebler PH, Schmidt D, Stamper CE, Hassell Jr. JE, Yamashita PS, Fox JH, Reber SO, Brenner LA, Hoisington AJ, Postolache TT, Kinney KA, Marciani D, Hernandez M, Hemmings SMJ, Malan-Muller S, Wright KP, Knight R, Raison CL, Rook GAW. The Microbiota, Immunoregulation, and Mental Health: Implications for Public Health. Curr Environ Health Rep 3(3):270-86.
  • Reber SO, Siebler PH, Donner NC, Morton JT, Smith DG, Kopelman JM, Lowe KR, Wheeler KJ, Fox JH, Hassell Jr JE, Greenwood BN, Jansch C, Lechner A, Schmidt D, Uschold-Schmidt N, Füchsl AM, Langgartner D, Walker FR, Hale MW, Lopez Perez G, Van Treuren W, González A, Halweg-Edwardsf AL, Fleshner M, Raison CL, Rook GA, Peddada SD, Knight R, Lowry CA. Immunization with a heat-killed preparation of the environmental bacterium Mycobacterium vaccae promotes stress resilience in mice. Proc Natl Acad Sci 113(22):E3130-9.
  • Füchsl AM & Reber SO. Chronic psychosocial stress and negative feedback inhibition: enhanced hippocampal glucocorticoid signaling despite lower cytoplasmic GR expression. PlosOne 11(4) e0153164.

2015

  • Langgartner D, Füchsl AM, Uschold-Schmidt N, Slattery DA, Reber SO. Chronic subordinate colony housing paradigm: A mouse model to characterize the consequences of insufficient glucocorticoid signalling. Frontiers in Psychiatry. 6 (18), 1-18.
  • Perani CV, Neumann ID, Reber SO*, & Slattery DA*. High fat diet prevents adaptive peripartum-associated adrenal gland plasticity and anxiolysis. Nature Scientific Report. 5:14821.

2014

  • Bartlang MS, Savelyev SA, Johansson AS, Reber SO, Helfrich-Förster C and Lundkvist GBS. Repeated psychosocial stress at night, but not day, affects the central molecular clock in male mice. Chronobiology International 7: 1-12
  • Forkwa TK, Neumann ID, Tamm ER, Ohlmann A*, Reber SO*. Short-term psychosocial stress protects photoreceptors from damage via a corticosterone-mediated activation of the Akt pathway. Experimental Neurology 252:28-36
  • Füchsl AM, Neumann ID, Reber SO. Stress resilience - a low-anxiety genotype protects male mice from the consequences of chronic psychosocial stress. Endocrinology 155(1):117-26.
  • Peters, S, Slattery, DA, Uschold-Schmidt, N, Reber, SO*, Neumann, ID*. Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice. Psychoneuroendocrinology, 42, 225-236.
  • Reber SO. Neurobiologische Grundlagen von Stress - Grundlagen der Stressanfälligkeit und der Stressresistenz. Psychische und psychosomatische Gesundheit in der Arbeit, eds Angerer P, Glaser J, Gündel H, Henningsen P, Lahmann C, Letzel S, & Nowak D (ecomed MEDIZIN, eine Marke der Verlagsgruppe Hüthig Jehle Rehm GmbH), Vol Thema Jahrestagung DGAUM 2013, pp 133-155.

2013

  • Czech B, Neumann ID, Müller M, Reber SO*, Hellerbrand C*. Effect of chronic psychosocial stress on nonalcoholic steatohepatitis in mice. International Journal of Clinical and Experimental Pathology 6(8): 1585-93
  • Füchsl AM, Langgartner D, Reber SO. Mechanisms underlying the increased plasma ACTH levels in chronic psychosocially stressed male mice. PLoS One 8(12):e84161.
  • Füchsl AM, Uschold-Schmidt N, Reber SO. Chronic psychosocial stress in male mice causes an up-regulation of scavenger receptor class B type 1 protein in the adrenal glands. Stress 16(4): 461-8
  • Peters S, Slattery DA, Flor PJ, Neumann ID, Reber SO. Differential effects of baclofen and oxytocin on the increased ethanol consumption following chronic psychosocial stress in mice. Addiction Biology 18(1): 66-77
  • Uschold-Schmidt N, Peterlik D, Füchsl AM, Reber SO. HPA axis changes during the initial phase of psychosocial stressor exposure in male mice. Journal of Endocrinoloy 218(2): 193-203

2012

  • Bartlang MS, Neumann ID, Slattery DA, Uschold-Schmidt N, Kraus D, Helfrich-Förster C, Reber SO. Time matters: pathological effects of repeated psychosocial stress during the active, but not inactive, phase of male mice. Journal of Endocrinology 215(3): 425-37.
  • Beiderbeck DI, Reber SO, Havasi A, Bredewold R, Veenema AH, Neumann ID. High and abnormal forms of aggression in rats with extremes in trait anxiety - Involvement of the dopamine system in the nucleus accumbens. Psychoneuroendocrinology 37(12): 1969-80.
  • Uschold-Schmidt N, Nyuyki KD, Füchsl AM, Neumann ID, Reber SO. Chronic psychosocial stress results in sensitization of the HPA axis to acute heterotypic stressors despite a reduction of adrenal in vitro ACTH responsiveness. Psychoneuroendocrinology 37(10): 1676-87. Uschold-Schmidt N and Reber SO were awared by the German Society of Endocrinology with the Ernst and Berta Scharrer Prize 2010 for research reported in this article.
  • Nyuyki KD, Beiderbeck DI, Lukas M, Neumann ID, Reber SO. Chronic subordinate colony housing (CSC) as a model of chronic psychosocial stress in male rats. PLoS One 7(12):e52371doi: 10.1371/journal.pone.0052371.
  • Nyuyki KD, Maloumby R, Reber SO, Neumann ID. Effect of blood collection technique on plasma corticosterone concentrations in the mice under different stress conditions. Stress 15(6): 618-26.
  • Peters S, Grunwald N, Rümmele P, Endlicher E, Lechner A, Neumann ID, Obermeier F, Reber SO. Chronic psychosocial stress increases the risk for inflammation-related colon carcinogenesis in male mice. Stress 15(4): 403-15.
  • Slattery DA, Uschold N, Magoni M, Baer J, Popoli M, Neumann ID, Reber SO. Behavioural consequences of two chronic psychosocial stress paradigms: anxiety without depression. Psychoneuroendocrinology 37(5): 702-14.
  • Reber SO. Stress and animal models of inflammatory bowel disease – an update on the role of the hypothalamo-pituitary-adrenal axis. Review article Psychoneuroendocrinology37(1): 1-19.

2011

  • Hillerer K, Reber SO, Neumann ID, Slattery DA. Exposure to chronic pregnancy stress reverses peripartum-associated adaptations: implications for postpartum anxiety and mood disorders. Endocrinology 152(10):3930-40
  • Lukas M, Toth I, Reber SO, Slattery DA, Veenema AH, Neumann ID. The neuropeptide oxytocin facilitates pro-social behavior and prevents social avoidance in rats and mice. Neuropsychopharmacology 36(11):2159-68
  • Reber SO, Peters S, Slattery DA, Hofmann C, Schölmerich J, Neumann ID, Obermeier F. Mucosal immunosuppression and epithelial barrier defects are key events in murine psychosocial stress-induced colitis. Brain, Behavior, and Immunity 25(6): 1153-1161

2010

  • Schmidt D*, Reber SO*, Botteron C, Barth T, Peterlik D, Uschold N, Neumann ID, Männel DN, Lechner A. Chronic psychosocial stress drives systemic immune activation and the development of inflammatory Th cell responses. Brain, Behavior, and Immunity24: 1097–1104

2009

  • Singewald GM, Nguyen NK, Neumann ID, Singewald N, Reber SO. Effect of chronic psychosocial stress induced by subordinate colony (CSC) housing on brain neuronal activity patterns in mice. Stress 12:58-69

2008

  • Reber SO and Neumann ID. Defensive Behavioral Strategies and Enhanced State Anxiety during Chronic Subordinate Colony Housing Are Accompanied by Reduced Hypothalamic
  • Vasopressin, But Not Oxytocin, Expression. AnnalsNYASci 1148:184-195
  • Reber SO, Obermeier F, Straub RH, Veenema AH, Neumann ID. Aggravation of DSS-induced colitis after chronic subordinate colony (CSC) housing is partially mediated by adrenal. Stress 11:225-234
  • Veenema AH*, Reber SO*, Selch S, Obermeier F, Neumann ID. Early Life Stress Enhances the Vulnerability to Chronic Psychosocial Stress and Experimental Colitis in Adult Mice. Endocrinology 149:2727-2736

2007

  • Reber SO, Birkeneder L, Veenema AH, Obermeier F, Falk W, Straub RH, Neumann ID. Adrenal Insufficiency and Colonic Inflammation after a Novel Chronic Psycho-Social Stress Paradigm in Mice: Implications and Mechanisms. Endocrinology 148:670-682

2006

  • Reber SO, Obermeier F, Straub RH, Falk W, Neumann ID. Chronic intermittent psychosocial stress (social defeat/overcrowding) in mice increases the severity of an acute DSS-induced colitis and impairs regeneration. Endocrinology 147:4968-4976

2003

  • Stefanski V, Peschel A, Reber SO. Social stress affects migration of blood T cells into lymphoid organs. J Neuroimmunol 138:17-24