Dr. rer. nat. Dipl.-​Psych. Michael Fritz

Stellvertretender therapeutischer Direktor

Leitung Sektion Molekulare Genetik und forensische Verhaltenswissenschaften

E-Mail michael.fritz@bkh-guenzburg.de

 

Werdegang
2000 - 2008Magisterstudium Psychologie Leopold-Franzens Universität Innsbruck
2001 - 2003Bakkalaureats Studium Philosophie Leopold-Franzens Universität Innsbruck
2003 - 2004Magisterstudium Philosophie Leopold-Franzens Universität Innsbruck
2008 - 2010Studium zum Doktor der Psychologie (Dr. rer. nat.) an der Abteilung für Experimentelle Psychiatrie der Medizinischen Universität Innsbruck unter Anleitung von Herrn ao. Univ.-Professor Dr. med. univ. Gerald Zernig
2010Promotion (mit Auszeichnung) über das Thema „Cocaine relapse prevention by social interaction and sigma 1 receptor inactivation: Development of an animal model“
2010 - 2014Wissenschaftlicher Mitarbeiter am Institut für Klinische und Experimentelle Medizin der Universität Linköping, Schweden (Labor von Herrn Univ. Professor David Engblom). Mitarbeit an den Projekten „Circuits and mechanisms behind sickness-induced aversion and depressive symptoms“ und „Inflammation-induced aversion: Brain Circuitry and Molecular Mechanisms“
2014 - 2020Assistenz (Junior) Professor am Zentrum für Soziale und Affektive Neurowissenschaften der Universität Linköping (Zentrumleitung Univ. Professor DDr. Markus Heilig). Leitung von Forschungsprojekten über Sigma 2 und Acetylcholin Rezeptoren als molekulare Ziele zur Behandlung von Kokainabhängigkeit.
2016 - 20173monatiger Aufenthalt als Gastwissenschaftler am Nationalen Institut für Drogensucht (NIDA) und dem Johns Hopkins Krankenhaus, Baltimore, USA im Labor von Dr. Michael Michaelides
2018 - 2020Gastlektor am Institut für Psychiatrie und Verhaltenswissenschaften, Stanford School of Medicine, Stanford Universität, USA

2020 - 2022

Wissenschaftlicher Mitarbeiter am Lehrstuhl für Forensische Psychiatrie und Psychotherapie der Universität Ulm, Prof. Manuela Dudeck und Stationspsychologe an der Klinik für Forensische Psychiatrie und Psychotherapie am BKH Günzburg
2021 - 2022

Dozent an der IU Internationale Hochschule für die Kurse Allgemeine Psychologie I, Biopsychologie: neurobiologische Grundlagen der Psychologie und Klinische Psychologie Störungslehre

2021 - 2024Ausbildung zum Fachpsychologen für Rechtspsychologie
2022 - 2024Professor für Psychologie und Studiengangleiter für den Bachelorstudiengang Psychologie an der AKAD Hochschule Stuttgart
2021 -Leitung der Sektion für Molekulare Genetik und Forensische Verhaltenswissenschaften am Lehrstuhl für Forensische Psychiatrie und Psychotherapie der Universität Ulm, Prof. Manuela Dudeck
2024 -Stellvertretender therapeutischer Direktor der Klinik für Forensische Psychiatrie und Psychotherapie der Universität Ulm am BKH Günzburg

 

Publikationen
Wissenschaftliche Artikel

Wissenschaftliche Artikel (Präklinik)

Fritz M, El Rawas R, Salti A, Klement S, Bardo MT, Kemmler G, Dechant G, Saria A, Zernig G.Reversal of cocaine-conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats. Addict Biol. 2011, 16(2):273-84. doi: 10.1111/j.1369-1600.2010.00285.x.

Fritz M, Klement S, El Rawas R, Saria A, Zernig G. Sigma1 receptor antagonist BD1047 enhances reversal of conditioned place preference from cocaine to social interaction.
Pharmacology. 2011, 87(1-2):45-8. doi: 10.1159/000322534.

Fritz M, El Rawas R, Klement S, Kummer K, Mayr MJ, Eggart V, Salti A, Bardo MT, Saria A, Zernig G. Differential effects of accumbens core vs. shell lesions in a rat concurrent conditioned place preference paradigm for cocaine vs. social interaction.PLoS One. 2011, 6(10):e26761. doi: 10.1371/journal.pone.0026761.

El Rawas R, Klement S, Kummer KK, Fritz M, Dechant G, Saria A, Zernig G. Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction. Front Behav Neurosci. 2012, 6:63. doi: 10.3389/fnbeh.2012.00063.

El Rawas R, Klement S, Salti A, Fritz M, Dechant G, Saria A, Zernig G. Preventive role of social interaction for cocaine conditioned place preference: correlation with FosB/DeltaFosB and pCREB expression in rat mesocorticolimbic areas. Front Behav Neurosci. 2012, 2;6:8. doi: 10.3389/fnbeh.2012.00008. 

Fritz M, Klawonn AM, Nilsson A, Singh AK, Zajdel J, Wilhelms DB, Lazarus M, Löfberg A, Jaarola M, Kugelberg UÖ, Billiar TR, Hackam DJ, Sodhi CP, Breyer MD, Jakobsson J, Schwaninger M, Schütz G, Parkitna JR, Saper CB, Blomqvist A, Engblom D. Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice. J Clin Invest. 2016, 126(2):695-705. doi: 10.1172/JCI83844.

Singh AK, Zajdel J, Mirrasekhian E, Almoosawi N, Frisch I, Klawonn AM, Jaarola M, Fritz M, Engblom D. Prostaglandin-mediated inhibition of serotonin signaling controls the affective component of inflammatory pain. J Clin Invest. 2017, 3;127(4):1370-1374. doi: 10.1172/JCI90678. 

Klawonn AM, Nilsson A, Rådberg CF, Lindström SH, Ericson M, Granseth B, Engblom D, Fritz M. The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum. Front Pharmacol. 2017, 8:714. doi: 10.3389/fphar.2017.00714.

Fritz M, Klawonn AM, Jaarola M, Engblom D. Interferon-ɣ mediated signaling in the brain endothelium is critical for inflammation-induced aversion. Brain Behav Immun. 2018, 67:54-58. doi: 10.1016/j.bbi.2017.08.020.

Klawonn AM, Wilhelms DB, Lindström SH, Singh AK, Jaarola M, Wess J, Fritz M1, Engblom1 D. Muscarinic M4 Receptors on Cholinergic and Dopamine D1 Receptor-Expressing Neurons Have Opposing Functionality for Positive Reinforcement and Influence Impulsivity. Front Mol Neurosci. 2018, 11:139. doi: 10.3389/fnmol.2018.00139.

Klawonn AM1, Fritz M1, Nilsson A, Bonaventura J, Shionoya K, Mirrasekhian E, Karlsson U, Jaarola M, Granseth B, Blomqvist A, Michaelides M, Engblom D.  Motivational valence is determined by striatal melanocortin 4 receptors. J Clin Invest. 2018, 128(7):3160-3170. doi: 10.1172/JCI97854. 

Zhao Q, Fritz M, Pfefferbaum A, Sullivan EV, Pohl KM, Zahr NM. Jacobian Maps Reveal Under-reported Brain Regions Sensitive to Extreme Binge Ethanol Intoxication in the Rat. Front Neuroanat. 2018, 12:108. doi: 10.3389/fnana.2018.00108.

Fritz M, Klawonn AM, Zhao Q, Sullivan EV, Zahr NM, Pfefferbaum A. Structural and biochemical imaging reveals systemic LPS-induced changes in the rat brain. J Neuroimmunol. 2020, 348:577367. doi: 10.1016/j.jneuroim.2020.577367.

Klawonn AM1, Fritz M1, Castany S, Pignatelli M, Canal C, Simil F, Tejeda HA, Levinsson J, Jaarola M, Jakobsson J, Hidalgo J, Heilig M, Bonci A, Engblom D. Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons. Immunity, 2021, 54:1-10 doi.org/10.1016/j.immuni.2020.12.016
Manning C. E., Fritz M., Kauer J. Function of Periaqueductal Gray Synapses in the Ventral Tegmental Area following inflammatory injury. ENeuro, 2022, 1-13, doi.org/10.1523/ENEURO.0324-22.2022

Fritz M, Björk-Wilhelms D, Jaarola M, Ruud J, Englbom D, Klawonn AM. Nicotinic α7 receptors function as auto-receptors in the striatum and mediate cocaine-reinforcement, but not food reward. (in Revision in Frontiers in molecular Neuroscience)

 

Wissenschaftliche Artikel (Klinik)

Fritz M, Wallner R, Grohs U, Kemmler G, Saria A, Zernig G. Comparable sensitivities of urine cotinine and breath carbon monoxide at follow-up time points of three months or more in a smoking cessation trial. Pharmacology. 2010, 85(4):234-40. doi: 10.1159/000280435

Fritz M, Shenar R, Cardenas-Morales L, Jäger M, Streb J, Dudeck M, Franke I. Aggressive and Disruptive Behavior Among Psychiatric Patients With Major Depressive Disorder, Schizophrenia, or Alcohol Dependency and the Effect of Depression and Self-Esteem on Aggression. Front Psychiatry. 2020, 11:599828. doi: 10.3389/fpsyt.2020.599828. 

Fritz M, Rösel F, Dobler H, Streb J, Dudeck M. Childhood trauma, the combination of MAO-A and COMT genetic polymorphisms and the joy of being aggressive in forensic psychiatric patients. Brain Sciences, 2021, 11(1008):1-11 doi.org/10.3390/brainsci11081008

Streb J, Lutz M, Dudeck M, Klein V, Maaß C, Fritz M & Franke I: Are women really different?  Comparison of Men and Women in a Sample of Forensic Psychiatric Inpatients. Frontiers in Psychiatry, 2022, doi:10.3389/fpsyt.2022.857468

Mayer J, Vasic N, Wolf V, Steiner I, Klein V, Fritz M, Rothe P, Streb J & Dudeck M, Gender Differences in the Pharmacological Treatment of Forensic In-Patients With Schizophrenia. Frontiers in Psychiatry, 2022, doi:10.3389/fpsyt.2022.907123

Fritz M, Karanassios G, Wolf V, Mayer J, Steiner I, Franke I, Klein V, Streb J, Dudeck M, The curse of experiencing and committing violence as a criminal recidivism predictor: a comparison between female forensic psychiatric patients with severe mental disorders and substance use disorder. European Psychiatry, 2023, 66(1):1-6 doi.org/10.1192/j.eurpsy.2023.2450

Soravia S-M, Gosemärker A-K, Streb J, Dudeck M, Fritz M, Does gender-specific suicidal symptomatology exist? Initial work on a partially-novel, multi-questionnaire-based characterization of acute suicidal patients. Cogent Psychology, 2024, 11(1):1-8 DOI: 10.1080/23311908.2024.2328911

Pichlmeier S, Streb J, Rösel F-A, Dobler H, Dudeck M, Fritz M, Subjective and Objective Assessments of Executive Functions are Independently Predictive of Aggressive Tendencies in patients with substance use disorder. Comprehensive Psychiatry, 2024, 132:1-8 DOI: 10.1016/j.comppsych.2024.152475

Fritz M, Montiel F, Al Dirany A, Dudeck M, Streb J, Unravelling Relapse in Male Forensic Psychiatric Patients with Substance Use Disorders – The Impact of Social, Psychiatric, and Personality Factors Post Long-term Remission. International Journal of Mental Health and Addiction, 2024, 1-16 doi.org/10.1007/s11469-024-01333-w 

Fritz M, Montiel F, Karanassios G, Dudeck M, Streb J, The relationship between Serum Cholesterol, Triglycerides and self-reported Appetitive and Reactive Aggression, as well as Violent Crimes in Male Forensic Patients with Substance Use Disorder (in Revision in mdpi Psychiatry International)  

 

Review Artikel

Fritz M, Klawonn AM, Zahr NM; Neuroimaging in alcohol use disorder: From mouse to man.
J Neurosci Res. 2019, doi: 10.1002/jnr.24423

Lutz M, Zani D, Fritz M, Dudeck M, Franke I, A Review and Comparative Analysis of the Risk-Needs-Responsivity, Good Lives, and Recovery Models in Forensic Psychiatric Treatment. Frontiers in Psychiatry, 2022, 1-12, doi.org/10.3389/fpsyt.2022.988905

Fritz M, Moravia S.-M., Dudeck M, Fakhoury M. Neurobiology of Aggression – Review of Recent Findings and Relationship with Alcohol and Trauma. MDPI Biology, 2023, 12(3):469. doi.org/10.3390/biology12030469 

 

Editorials

Fakhoury, M. & Fritz, M. Neurobiology of Behavior – Influences of Neuropsychiatric Disorders on Neurobiology and Behavior. MDPI Biology 2023 12(6):807. doi.org/10.3390/biology12060807

 

Buchkapitel

Klawonn AM, Fritz M. Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair. Neuromethods, 2021, 165, pp. 145–167

Fritz M, Dudeck M. Die Neurobiologie der Delinquenz. Praxishandbuch Forensische Psychiatrie 2022, 3 Auflage

Fakhoury M, Fritz M, Sleiman SF. Behavioral paradigms for assessing cognitive functions in the chronic social defeat stress model of depression. Translational Research Methods for Major Depressive Disorder, 2022, pp. 147-164

 

Lernmittel

Bender B, Fritz M, PSY271 Grundlagen der Sozialpsychologie (Studienbrief), AKAD-University of applied Sciences, 2023, 1-87, Kennnummer: N2023

Wittling C, Fritz M, PSY281 Einführung in die Psychologische Diagnostik (Studienbrief), AKAD-University of applied Sciences, 2023, 1-99, Kennnummer: N2122

Wittling C, Fritz M, PSY332 Überblicke über die Persönlichkeit (Studienbrief), AKAD-University of applied Sciences, 2023, 1-90, Kennnummer: N2113

Fritz M, Wittling C, PSY921 Grundlagen der Biologischen Psychologie (Studienbrief), AKAD-University of applied Sciences, 2024, 1-93, Kennnummer: N2074

 

1Diese Autoren teilen die Erst- bzw. Letzt-Autorenschaft.