Originalarbeiten der AG Barth der letzten 5 Jahre

Caniglia, C., Valavanis, D., Tezcan, G., Magiera, J., Barth, H., Bansmann, J., Kranz, C., and Unwin, P. R. (2024). Antimicrobial effects of silver nanoparticle-microspots on the mechanical properties of single bacteria. Analyst. 2024 Mar 26. doi: 10.1039/d4an00174e.

Ramm, F.§,*, Kaser, D.§, König, I., Fellendorf, J., Wenzel, D., Zemella, A., Papatheodorou, P., Barth, H., and Schmidt, H.* (2024). Synthesis of biologically active Shiga toxins in cell-free systems. Sci. Rep. 2024 Mar 13;14(1):6043. doi: 10.1038/s41598-024-56190-3. 

Jia, J.§, Zoeschg, M.§, Barth, H., Pulliainen A. T., and Ernst, K. (2024). The chaperonin TRiC/CCT inhibitor HSF1A protects cells from intoxication with pertussis toxin. Toxins 2024, 16 (1), 36; doi.org/10.3390/toxins16010036.

Papatheodorou, P., Minton, N. P., Aktories, K., and Barth, H. (2024). An updated view on the cellular uptake and mode-of-action of Clostridioides difficile toxins. Adv. Exp. Med. Biol. 2024; 1435:219-247. doi: 10.1007/978-3-031-42108-2_11. PMID: 38175478.

Barth, H.*, Worek, F., Steinritz, D., Papatheodorou, P., and Huber-Lang, M.* (2023). Trauma-Toxicology: Concepts, Causes, Complications. Naunyn-Schmiedeberg’s Arch. Pharmacol. doi: 10.1007/s00210-023-02845-3.

Schmid, R., Volcic, M., Fischer, S., Qu, Z., Barth, H., Popat, A., Kirchhoff, F., and Lindén, M. (2023). Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model. Sci. Rep. 13(1):20175. doi: 10.1038/s41598-023-47445-6.

Teuber, A., Caniglia, G., Barth, H., Kranz, C., and Mizaikoff, B. (2023). Thin-film waveguide laser spectroscopy: a novel platform for bacterial analysis. Anal Chem. 95(45):16600-16608. doi: 10.1021/acs.analchem.3c02782. Epub 2023 Oct 26.

Schumacher, J., Nienhaus, A., Heber, S., Matylitsky, J., Chaves-Olarte, E., Rodríguez, C., Barth, H.*, and Papatheodorou, P.* (2023). Exploring the inhibitory potential of the antiarrhythmic drug Amiodarone against Clostridioides difficile toxins TcdA and TcdB. Gut and Microbes. 15(2):2256695. doi: 10.1080/19490976.2023.2256695. Epub 2023 Sep 25.

Kling, C., Sommer, A., Almeida-Hernandez, Y., Rodríguez, A., Pérez-Erviti, J. A., Bhadane, R., Ständker, L., Wiese, S., Barth, H., Pupo-Meriño, M., Pulliainen, A. T., Sanchez-Garcia, E., and Ernst, K. (2023). Inhibition of Pertussis toxin by α-defensin-1 and -5: Differential mechanisms of action. Int. J. Mol. Sci. 2023 Jun 23;24(13):10557. doi: 10.3390/ijms241310557.

Heber, S.^§, Borho, J.^§, Stadler, N., Wondany, F., König, I., Michaelis, J., Papatheodorou, P., Barth,H.*, and Fellermann, M.* (2023). The Clostridium botulinum C2 Toxin subunit C2IIa delivers enzymes with positively charged N-termini into the cytosol of target cells. Toxins 15(6), 390; doi.org/10.3390/toxins15060390.

Jia, J., Braune-Yan, M., Lietz, S., Wahba, M., Pulliainen, A. T., Barth, H., and Ernst, K. (2023). Domperidone inhibits Clostridium botulinum C2 toxin and Bordetella pertussis toxin. Toxins 15(7), 412. doi: 10.3390/toxins15070412.

Braune-Yan, M., Jia, J., Wahba, M., Schmid, J., Papatheodorou, P., Barth, H., and Ernst, K. (2023). Hsp70 is required for the cellular uptake of Clostridioides difficile toxin TcdB. Toxins 15(6), 384. doi: 10.3390/toxins15060384.

Gierse, M., Nagel, L., Keim, M., Lucas, S., Speidel, T., Lobmeyer, T., Winter, G., Josten, F., Karaali, S., Fellermann, M., Scheuer, J., Müller, C., van Heijster, F., Skinner, J., Löffler, J., Parker, A., Handwerker, J., Marshall, A., El-Kassem, B., Vassiliou, C., Blanchard, J. W., Eills, J., Barth, H., Jelezko, F., Rasche, V., Schilling, F., Schwartz, I., and Knecht, S. (2023). Parahydrogen-polarized fumarate for preclinical in vivo metabolic magnetic resonance imaging. J. Am. Chem. Soc. 15;145(10):5960-5969. doi: 10.1021/jacs.2c13830.

Bajrami, D., Fischer, S., Barth, H., Hossain, S.I., Cioffi, N., and Mizaikoff, B. (2022). Antimicrobial efficiency of chitosan and its methylated derivative against Lentilactobacillus parabuchneri biofilms. Molecules. 2022 Dec 7;27(24):8647. doi: 10.3390/molecules27248647.

Caniglia, G., Teuber, A., Barth, H., Mizaikoff, B., and Kranz, C. (2022). Atomic force and infrared spectroscopic studies on the role of surface charge for the anti-biofouling properties of polydopamine films. Anal. Bioanal. Chem. 2022 Nov 24. doi: 10.1007/s00216-022-04431-7.

Fellermann, M., Stemmer, M., Noschka, R., Wondany, F., Fischer, S., Michaelis, J., Stenger, S., and Barth, H. (2022). Clostridium botulinum C3 toxin for selective delivery of cargo into dendritic cells and macrophages. Toxins 2022, 14(10), 711; doi.org/10.3390/toxins14100711.

Bajrami, D., Fischer, S., Barth, H., Sarquis, M.A., Ladero, V.M., García, M.F., Sportelli, M.C., Cioffi, N., Kranz, C., and Mizaikoff, B. (2022). In situ monitoring of Lactobacillus parabuchneri biofilm formation via real-time infrared spectroscopy. NPJ Biofilms and Microbiomes 2022 Nov 19;8(1):92. doi: 10.1038/s41522-022-00353-5.

Caniglia, G., Sportelli, M.C., Heinzmann, A., Picca, R.A., Valentini, A., Barth, H., Mizaikoff, B., Cioffi, B., and Kranz, C. (2022). Silver-fluoropolymer (Ag-CFX) films: kinetic study of silver release, and spectroscopic-microscopic insight into the inhibition of P. fluorescens biofilm formation. Analytical Chimica Acta. 1212:339892. doi: 10.1016/j.aca.2022.339892.

Sessler, K,, Schmidt, H., and Barth, H. (2022). Novel aspects of the SubA subunit of the subtilase cytotoxin. Toxins. 14, 156. doi: 10.3390/toxins14020156.

Barthold, L., Heber, S., Schmidt, C.Q., Gradl, M., Weidinger, G., Barth, H.*, and Fischer, S.* (2022). Human α-Defensin-6 neutralizes Clostridioides difficile toxins TcdA and TcdB by direct binding. Int. J. Mol. Sci. 23, 4509.

Eisele, J.^§, Schreiner, S.^§, Borho, J.^§, Fischer, S., Heber, S., Endres, S., Fellermann, M., Wohlgemuth, L., Huber-Lang, M., Fois, G., Fauler, M., Frick, M,, and Barth, H. (2022). The pore-forming subunit C2IIa of the binary Clostridium botulinum C2 toxin reduces the chemotactic translocation of human polymorphonuclear leukocytes. Front. Pharmacol. 11 February 2022 | doi.org/10.3389/fphar.2022.810611.

Heber, S., Barthold, L., Baier, J., Papatheodorou, P., Fois, G., Frick, M., Barth, H.*, and Fischer, S.* (2022). Inhibition of Clostridioides difficile toxins TcdA and TcdB by Ambroxol. Front. Pharmacol. 12:809595.doi: 10.3389/fphar.2021.809595. eCollection 2021.

Naskar, N., Liu, W., Qi, H., Stumper, A., Fischer, S., Diemant, T., Behm, R.J., Kaiser, U., Rau, S., Weil, T., and Chakrabortty, S. (2022). A carbon nanodot based near-infrared photosensitizer with a protein-ruthenium shell for low-power photodynamic applications. ACS Appl. Mater. Interfaces. 2022 Nov 2;14(43):48327-48340. doi: 10.1021/acsami.2c08585.

Ernst, K. (2022). Novel strategies to inhibit Pertussis toxin. Toxins (Basel). 2022 Mar 3;14(3):187. doi: 10.3390/toxins14030187.

Ernst, K. (2022). Requirement of Peptidyl-Prolyl Cis/Trans isomerases and chaperones for cellular uptake of bacterial AB-type toxins. Front. Cell Infect. Microbiol. 2022 Aug 4;12:938015. doi: 10.3389/fcimb.2022.938015.

Papatheodorou, P.*, Kindig, S., Badilla-Lobo, A., Fischer, S., Durgun, E., Thuraisingam, T., Witte, A., Song, S., Aktories, K, Chavez-Olarte, E., Rodriguez, C., and Barth, H. (2021). The compound U18666A inhibits the intoxication of cells by Clostridioides difficile toxins TcdA and TcdB. Front. Microbiol. doi: 10.3389/fmicb.2021.784856.

Hirschenberger, M., Stadler, N., Fellermann, M., Sparrer, K.M.J., Kirchhoff, F., Barth, H.*, and Papatheodorou, P.* CRISPA: A non-viral, transient Cas9 delivery system based on reengineered anthrax toxin. Front. Pharmacol.12:770283. doi: 10.3389/fphar.2021.770283.

Kling, C., Pulliainen, A. T., Barth, H., and Ernst, K. (2021). Human peptides α-defensin-1 and -5 inhibit pertussis toxin. Toxins 13:480. doi.org/10.3390/toxins13070480.

Ernst, K.*^,§, Landenberger, M.^§, Nieleand, J., Nørgaard, K., Frick, M., Fois, G., Benz, R., and Barth, H.* (2021). Characterization and pharmacological inhibition of the pore-forming Clostridioides difficile CDTb toxin. Toxins13:390. doi.org/10.3390/toxins13060390.

Heinisch, L., Krause, M., Roth, A., Barth, H., and Schmidt, H. (2021). Cytotoxic effects of recombinant StxA2-His in absence of its corresponding B-subunit. Toxins13(5):307. doi: 10.3390/toxins13050307.  

Wu, Y., Alam, M.N.A., Balasubramanian, P., Ermakova, A., Fischer, S., Barth, H., Wagner, M., Raabe, M., Jelezko, F., and Weil, T. (2021): Nanodiamond theranostic for light-controlled intracellular heating and nanoscale temperature sensing. Nano Letters. doi: 10.1021/acs.nanolett.1c00043.    

Landenberger, M.^§, Nieland, J.^§, Roeder, M., Nørgaard, M., Papatheodorou, P., Ernst, K.*, and Barth, H. (2021). The cytotoxic effect of Clostridioides difficile pore-forming toxin CDTb. Biochim. Biophys. Acta Biomembr. 1863(6):183603.

Ernst, K.^§,*, Mittler, A.-K.^§, Winkelmann, V., Kling, C.,Eberhardt, N., Anastasia, A., Sonnabend, M., Lochbaum, R., Wirsching, J., Sakari, M., Pulliainen, A. T., Skerry, C., Carbonetti, N. H., Frick, M., and Barth, H.* (2021). Pharmacological targeting of host chaperones protects from pertussis toxin in vitro and in vivo. Sci. Rep. 11(1):5429.

Sessler, K., Papatheodorou, P., Wondany, F., Krause, M., Noettger, S., Bernhardt, D., Michaelis, J., Schmidt, H., and Barth, H. (2021).The enzyme subunit SubA of E. coli subtilase cytotoxin demonstrates comparable intracellular transport and cytotoxic activity as the holotoxin SubAB. Arch. Toxicol. 95(3):975-983.

Ernst, K.^§,*, Sailer, J.^§, and Barth, H.* (2020). Intoxication of mammalian cells with binary clostridial enterotoxins is inhibited by the combination of pharmacological chaperone inhibitors. Naunyn-Schmiedeberg’s Arch. Pharmacol. doi: 10.1007/s00210-020-02029-3.

Jansen, F., Lamla, M., Mauthe, D., Fischer, S., Barth, H., and Kuehne, A.J.C. (2020). Croconaine-based polymer particles as contrast agents for photoacoustic imaging. Macromol. Rapid. Commun.41(22):e2000418. 

Deusser, H., Groh, I., Bakuradze, T., Simson, N., Kaiser, E., Barth, H., and Richling, E. Are compounds membrane-associated or present in the cytosol? (2020). A study using polyphenols in a colon carcinoma cell line model. Curr. Pharmacol. Rep. 6(6). DOI:10.1007/s40495-020-00242-5

Fellermann, M., Huchler, C., Fechter, L., Kolb, T., Wondany, F., Mayer, D., Michaelis, J., Stenger, S., Mellert, K., Möller, P., Barth, T.F.E., Fischer, S.^*, and Barth, H.^* (2020). Clostridial C3 toxins enter and intoxicate human dendritic cells. Toxins 12(9):E563.

Korbmacher, M.^§, Fischer, S.^§,*, Landenberger, M., Papatheodorou, P., Aktories, K., and Barth,H.* (2020). Human α-defensin-5 efficiently neutralizes Clostridioides difficile toxins TcdA, TcdB, and CDT. Front. Pharmacol.11:1204. eCollection 2020.

Felix, I., Lomada, S. K., Barth, H.*, and Wieland, T.* (2020). Bacillus anthracis’ PA63 delivers the tumor metastasis suppressor protein NDPK-A/NME1 into breast cancer cells. Int. J. Mol. Sci.21(9):3295.

Fellermann, M.^§, Wondany, F.^§, Carle, S., Nemeth, J., Sadhanasatish, T., Frick, M., Barth, H.*, and Michaelis, J.* (2020).Super-resolution microscopy unveils transmembrane domain-mediated internalization of cross-reacting material 197 into diphtheria toxin-resistant mouse J774A.1 cells and primary rat fibroblasts in vitro. Arch. Toxicol. 94(5):1753-1761.

Fischer, S., Ückert, A.K., Landenberger, M., Papatheodorou, P., Hoffmann-Richter, C., Mittler, A.K., Ziener, U., Hägele, M., Schwan, C., Müller, M., Kleger, A., Benz, R., Popoff, M. R., Aktories, K., and Barth, H.(2020). Human peptide α-defensin-1 interferes with Clostridioides difficile toxins TcdA, TcdB, and CDT. FASEB J. 34(5):6244-6261.

Wu, Y., Boulogne, C., Carle, S., Podinovskaia, M., Barth, H., Spang, A., Cintrat, J.-C., Gillet, D., and Barbier, J. (2020). Regulation of endo-lysosomal pathway and autophagic flux by broad-spectrum anti-pathogen inhibitor ABMA. FEBS J. 287(15):3184-3199.