Aktuelle Publikationen des Instituts

Schmidt, C.Q. (2024). It's all about complement balance, again. Blood. 2024 Mar 14;143(11):949-951. doi: 10.1182/blood.2023023334. PMID: 38483408.

Sonnentag, S.J., Dopler, A., Kleiner, K., Garg, B.K., Mannes, M., Späth, N., Akilah, A., Höchsmann, B., Schrezenmeier, H., Anliker, M., Boyanapalli, R., Huber-Lang, M., and Schmidt, C.Q. (2024). Triple-fusion protein (TriFu): A potent, targeted, enzyme-like inhibitor of all three complement activation pathways. J Biol Chem. 2024 Feb 23;300(4):105784. doi: 10.1016/j.jbc.2024.105784. Epub ahead of print. PMID: 38401844.

Biber, J., Jabri, Y., Glänzer, S., Dort, A., Hoffelner, P., Schmidt, C.Q., Bludau, O., Pauly, D., Grosche, A. (2024). Gliosis-dependent expression of complement factor H truncated variants attenuates retinal neurodegeneration following ischemic injury. J Neuroinflammation. 2024 Feb 22;21(1):56. doi: 10.1186/s12974-024-03045-3. PMID: 38388518; PMCID: PMC10885619.

Caniglia, C., Valavanis, D., Tezcan, G., Magiera, J., Barth, H., Bansmann, J., Kranz, C., and Unwin, P. R. (2024). Antimicrobial effects of silver nanoparticle-microspots on the mechanical properties of single bacteria. Analyst. 2024 Mar 26. doi: 10.1039/d4an00174e.

Ramm, F.^§,*, Kaser, D.^§, König, I., Fellendorf, J., Wenzel, D., Zemella, A., Papatheodorou, P., Barth, H., and Schmidt, H.* (2024). Synthesis of biologically active Shiga toxins in cell-free systems. Sci. Rep. 2024 Mar 13;14(1):6043. doi: 10.1038/s41598-024-56190-3.

Jia, J.^§, Zoeschg, M.^§, Barth, H., Pulliainen A. T., and Ernst, K. (2024). The chaperonin TRiC/CCT inhibitor HSF1A protects cells from intoxication with pertussis toxin. Toxins 2024, 16 (1), 36; https://doi.org/10.3390/toxins16010036.

Papatheodorou, P., Minton, N. P., Aktories, K., and Barth, H. (2024). An updated view on the cellular uptake and mode-of-action of Clostridioides difficile toxins. Adv. Exp. Med. Biol. 2024; 1435:219-247. doi: 10.1007/978-3-031-42108-2_11. PMID: 38175478.

Maier, C.P., Klose, C., Seitz, C.M., Heubach, F., Döring, M., Meisel, R., Schuster, F.R., Gruhn, B., Keller, F., Rabsteyn, A., Arendt, A.M., Amorelli, G., Eichholz, T., Feuchtinger, T., Martinius, H., Nierkens, S., Teltschik, R., Schulte, J.H., Lengerke, C., Handgretinger, R., Lang, P. (2024). Influence of ATLG Serum Levels on CD3/CD19-depleted Hematopoietic Grafts and on Immune Recovery in Pediatric Haplo-HSCT. Blood Adv. 2024 Jan 30:bloodadvances.2023011016. doi: 10.1182/bloodadvances.2023011016. Epub ahead of print. PMID: 38290133.

Barth H, Worek F, Steinritz D, Papatheodorou P, Huber-Lang M. Trauma-Toxicology: Concepts, Causes, Complications. Naunyn-Schmiedeberg’s Arch. Pharmacol. 2023. doi: 10.1007/s00210-023-02845-3.

Schmid R, Volcic M, Fischer S, Qu Z, Barth H, Popat A, Kirchhoff F, Lindén M (2023). Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model. Sci. Rep. 2023. 13(1):20175. doi: 10.1038/s41598-023-47445-6.

Mannes M, Pechtl V, Hafner S, Dopler A, Eriksson O, Manivel VA, Wohlgemuth L, Messerer DAC, Schrezenmeier H, Ekdahl KN, Nilsson B, Jacobsen EM, Hoenig M, Huber-Lang M, Braun CK, Schmidt CQ. Complement and platelets: prothrombotic cell activation requires membrane attack complex-induced release of danger signals. Blood Adv. 2023 Oct 24;7(20):6367-6380. doi: 10.1182/bloodadvances.2023010817. PMID: 37428869; PMCID: PMC10625899.

Teuber A, Caniglia G, Barth H, Kranz C, Mizaikoff B. Thin-film waveguide laser spectroscopy: a novel platform for bacterial analysis. Anal Chem. 2023. 95(45):16600-16608. doi: 10.1021/acs.analchem.3c02782. Epub 2023 Oct 26.

Hafner S, Seufferlein T, Kleger A, Müller M. Symptoms and Management of Aseptic Liver Abscesses. Z Gastroenterol. 2023 Oct 12. English. doi: 10.1055/a-2075-5082. Epub ahead of print. PMID: 37827501.

Golomingi M, Kohler J, Lamers C, Pouw RB, Ricklin D, Dobó J, Gál P, Pál G, Kiss B, Dopler A, Schmidt CQ, Hardy ET, Lam W, Schroeder V. Complement inhibition can decrease the haemostatic response in a microvascular bleeding model at multiple levels. Front Immunol. 2023 Sep 13;14:1226832. doi: 10.3389/fimmu.2023.1226832. PMID: 37771595; PMCID: PMC10525698.

Schumacher J, Nienhaus A, Heber S, Matylitsky J, Chaves-Olarte E, Rodríguez C, Barth H, Papatheodorou P. Exploring the inhibitory potential of the antiarrhythmic drug Amiodarone against Clostridioides difficile toxins TcdA and TcdB. Gut and Microbes. 2023. 15(2):2256695. doi: 10.1080/19490976.2023.2256695. Epub 2023 Sep 25.

Funcke JB, Moepps B, Roos J, von Schnurbein J, Verstraete K, Fröhlich-Reiterer E, Kohlsdorf K, Nunziata A, Brandt S, Tsirigotaki A, Dansercoer A, Suppan E, Haris B, Debatin KM, Savvides SN, Farooqi IS, Hussain K, Gierschik P, Fischer-Posovszky P, Wabitsch M. Rare antagonistic leptin variants and severe, early-onset obesity. N. Engl. J. Med. 2023 388(24):2253-2261. doi: 10.1056/NEJMoa2204041. PMID: 37314706.

Li X, Wang H, Schmidt CQ, Ferreira VP, Yancopoulou D, Mastellos DC, Lambris JD, Hajishengallis G. The complement-targeted inhibitor Mini-FH protects against experimental periodontitis via both C3-dependent and C3-independent mechanisms. J. Immunol. 2023 Jun 12:ji2300242. doi: 10.4049/jimmunol.2300242. Epub ahead of print. PMID: 37306457.

Kling C, Sommer A, Almeida-Hernandez Y, Rodríguez A, Pérez-Erviti JA, Bhadane R, Ständker L, Wiese S, Barth H, Pupo-Meriño M, Pulliainen AT, Sanchez-Garcia E, Ernst K. 2023. Inhibition of Pertussis toxin by α-defensin-1 and -5: Differential mechanisms of action. Int. J. Mol. Sci. 2023, 24, 10557. doi.org/10.3390/ijms241310557.

Heber S, Borho J, Stadler N, Wondany F, König I, Michaelis J, Papatheodorou P, Barth H, Fellermann M. 2023. The Clostridium botulinum C2 Toxin subunit C2IIa delivers enzymes with positively charged N-termini into the cytosol of target cells. Toxins 15(6), 390; doi.org/10.3390/toxins15060390.

Jia J, Braune-Yan M, Lietz, S., Wahba M, Pulliainen AT, Barth H, Ernst K. 2023. Domperidone inhibits Clostridium botulinum C2 toxin and Bordetella pertussis toxin. Toxins. 15(7), 412; doi.org/10.3390/toxins15070412.

Braune-Yan M, Jia J, Wahba M, Schmid J, Papatheodorou P, Barth H, Ernst K. 2023. Domperidone protects cells from intoxication with Clostridioides difficile toxins by inhibiting Hsp70-assisted membrane translocation. Toxins 15(6):384. doi: 10.3390/toxins15060384. PMID: 37368685.

Keller F, Ludwig U, Huber-Lang M. Enemy or friend: the personal and the factual patient-physician relationship. Front. Med. (Lausanne). 2023 May 25;10:1098305. doi: 10.3389/fmed.2023.1098305.

Abdel-Kahaar E, Keller F. Clinical pharmacokinetics and pharmacodynamics of Voclosporin. Clin. Pharmacokinet. 2023 May 3. doi: 10.1007/s40262-023-01246-2.

Gerhards J, Maerz LD, Matthees ESF, Donow C, Moepps B, Premont RT, Burkhalter MD, Hoffmann C, Philipp M. Kinase activity is not required for G protein-coupled receptor kinase 4 restraining mTOR signaling during cilia and kidney development. J. Am. Soc. Nephrol. 2023 Apr 1;34(4):590-606. doi: 10.1681/ASN.0000000000000082.

Qi J, Endres S, Yosifov DY, Tausch E, Dheenadayalan RP, Gao X, Müller A, Schneider C, Mertens D, Gierschik P, Wist M, Jebaraj BMC, Stilgenbauer S. Acquired BTK mutations associated with resistance to non-covalent BTK inhibitors. Blood Adv. 2023 Jan 20:bloodadvances.2022008955. doi: 10.1182/bloodadvances.2022008955. Epub ahead of print. PMID: 36661329.

Gierse M, Nagel L, Keim M, Lucas S, Speidel T, Lobmeyer T, Winter G, Josten F, Karaali S, Fellermann M, Scheuer J, Müller C, van Heijster F, Skinner J, Löffler J, Parker A, Handwerker J, Marshall A, El-Kassem B, Vassiliou C, Blanchard JW, Eills J, Barth H, Jelezko F, Rasche V, Schilling F, Schwartz I, Knecht S. 2023. Parahydrogen-polarized fumarate for preclinical in vivo metabolic magnetic resonance imaging. J. Am. Chem. Soc. 2023 Mar 15;145(10):5960-5969. doi: 10.1021/jacs.2c13830.

van Essen MF, Peereboom ETM, Schlagwein N, van Gijlswijk-Janssen DJ, Nelemans T, Joeloemsingh JV, van den Berg CW, Prins J, Clark SJ, Schmidt CQ, Trouw LA, van Kooten C. 2023. Preferential production and secretion of the complement regulator factor H-like protein 1 (FHL-1) by human myeloid cells. Immunobiology. 2023 Feb 28;228(3):152364. doi: 10.1016/j.imbio.2023.152364.

Mannes M, Halbgebauer R, Wohlgemuth L, Messerer DAC, Savukoski S, Schultze A, Berger B, Knapp CL, Schmidt CQ, Fürst D, Hillmer M, Siebert R, Eriksson O, Persson B, Nilsson B, Nilsson Ekdahl K, Huber-Lang M. 2023. Combined heterozygous genetic variations in complement C2 and C8B: An explanation for multidimensional immune imbalance? J. Innate Immun. 2023 Mar 1;15(1):412-427. doi: 10.1159/000528607.

Hamed A, Yamaguchi LF, Valencia Morante EY, Spira B, Stammler HG, El Gaafary M, Ziegler D, Syrovets T, Simmet T, Kato MJ. Cannabinoid-like meroterpenoids from Peperomia incana. Phytochemistry. 2023 Mar;207:113551. doi: 10.1016/j.phytochem.2022.113551.

Bajrami D, Fischer S, Barth H, Hossain SI, Cioffi N, Mizaikoff B. 2022. Antimicrobial efficiency of chitosan and its methylated derivative against Lentilactobacillus parabuchneri biofilms. Molecules. 2022 Dec 7;27(24):8647. doi: 10.3390/molecules27248647.

Caniglia G, Teuber A, Barth H, Mizaikoff B, Kranz C. 2022. Atomic force and infrared spectroscopic studies on the role of surface charge for the anti-biofouling properties of polydopamine films. Anal. Bioanal. Chem. 2022 Nov 24. doi: 10.1007/s00216-022-04431-7.

Fellermann M, Stemmer M, Noschka R, Wondany F, Fischer S, Michaelis J, Stenger S, Barth H. 2022.Clostridium botulinum C3 toxin for selective delivery of cargo into dendritic cells and macrophages. Toxins 2022, 14(10), 711; doi.org/10.3390/toxins14100711.

Bajrami D, Fischer S,Barth H, Sarquis MA, Ladero VM, García MF, Sportelli MC, Cioffi N, Kranz C, Mizaikoff B. 2022. In situ monitoring of Lactobacillus parabuchneri biofilm formation via real-time infrared spectroscopy. NPJ Biofilms and Microbiomes2022 Nov 19;8(1):92. doi: 10.1038/s41522-022-00353-5.

Caniglia G, Sportelli MC, Heinzmann A, Picca RA, Valentini A, Barth H, Mizaikoff B, Cioffi B, Kranz C. 2022. Silver-fluoropolymer (Ag-CFX) films: kinetic study of silver release, and spectroscopic-microscopic insight into the inhibition of P. fluorescens biofilm formation. Analytical Chimica Acta. 1212:339892. doi: 10.1016/j.aca.2022.339892.

Sessler K, Schmidt H, Barth H. 2022. Novel aspects of the SubA subunit of the subtilase cytotoxin. Toxins. 14, 156. doi: 10.3390/toxins14020156.

Barthold L, Heber S, Schmidt CQ, Gradl M, Weidinger G, Barth H*, Fischer S* 2022. Human α-Defensin-6 neutralizes Clostridioides difficile toxins TcdA and TcdB by direct binding. Int. J. Mol. Sci. 23, 4509.

Eisele J^§, Schreiner S^§, Borho J^§, Fischer S, Heber S, Endres S, Fellermann M, Wohlgemuth L, Huber-Lang M, Fois G, Fauler M, Frick M, Barth H. 2022. The pore-forming subunit C2IIa of the binary Clostridium botulinum C2 toxin reduces the chemotactic translocation of human polymorphonuclear leukocytes. Front. Pharmacol. 11 February 2022 | doi.org/10.3389/fphar.2022.810611.

Heber S, Barthold L, Baier J, Papatheodorou P, Fois G, Frick M, Barth H*, Fischer, S.* 2022. Inhibition of Clostridioides difficile toxins TcdA and TcdB by Ambroxol. Front. Pharmacol. 12:809595.doi: 10.3389/fphar.2021.809595. eCollection 2021.

Naskar N, Liu W, Qi H, Stumper A, Fischer S, Diemant T, Behm RJ, Kaiser U, Rau S, Weil T, Chakrabortty S. 2022. A carbon nanodot based near-infrared photosensitizer with a protein-ruthenium shell for low-power photodynamic applications. ACS Appl. Mater. Interfaces. 2022 Nov 2;14(43):48327-48340. doi: 10.1021/acsami.2c08585.

Ernst K. 2022. Novel strategies to inhibit Pertussis toxin. Toxins (Basel). 2022 Mar 3;14(3):187. doi: 10.3390/toxins14030187.

Ernst K. 2022. Requirement of Peptidyl-Prolyl Cis/Trans isomerases and chaperones for cellular uptake of bacterial AB-type toxins. Front. Cell Infect. Microbiol. 2022 Aug 4;12:938015. doi: 10.3389/fcimb.2022.938015.

Zinngrebe J, Moepps B, Monecke T, Gierschik P, Schlichtig F, Barth TFE, Strauß G, Boldrin E, Posovszky C, Schulz A, Beringer O, Rieser E, Jacobsen EM, Lorenz MR, Schwarz K, Pannicke U, Walczak H, Niessing D, Schuetz C, Fischer-Posovszky P, Debatin KM. 2022. Compound heterozygous variants in OTULIN are associated with fulminant atypical late-onset ORAS. EMBO Mol Med. 2022 Mar 7;14(3):e14901. doi: 10.15252/emmm.202114901.

Jebaraj BMC, Müller A, Dheenadayalan RP, Endres S, Roessner PM, Seyfried F, Walliser C, Wist M, Qi J, Tausch E, Mertens D, Fox JA, Debatin KM, Meyer LH, Taverna P, Seiffert M, Gierschik P, Stilgenbauer S. 2022. Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia. Blood. 2022 Feb 10;139(6):859-875. doi: 10.1182/blood.2021011516.

Cyra M, Schulte M, Berthold R, Heinst L, Jansen EP, Grünewald I, Elges S, Larsson O, Schliemann C, Steinestel K, Hafner S, Simmet T, Wardelmann E, Kailayangiri S, Rossig C, Isfort I, Trautmann M, Hartmann W. 2022. SS18-SSX drives CREB activation in synovial sarcoma. Cell Oncol. (Dordr). 2022 Jun;45(3):399-413. doi: 10.1007/s13402-022-00673-w.

Zeiss R, Hafner S, Schönfeldt-Lecuona C, Connemann BJ, Gahr M. 2022. Drug-associated liver injury related to antipsychotics: Exploratory analysis of pharmacovigilance data. J. Clin. Psychopharmacol. 2022 Sep-Oct 01;42(5):440-444. doi: 10.1097/JCP.0000000000001576.

Anliker M, Drees D, Loacker L, Hafner S, Griesmacher A, Hoermann G, Fux V, Schennach H, Hörtnagl P, Dopler A, Schmidt S, Bellmann-Weiler R, Weiss G, Marx-Hofmann A, Körper S, Höchsmann B, Schrezenmeier H, Schmidt CQ. 2022. Upregulation of checkpoint ligand programmed death-ligand 1 in patients with paroxysmal nocturnal hemoglobinuria explained by proximal complement activation. J. Immunol. 2022 Mar 1;208(5):1248-1258. doi: 10.4049/jimmunol.2100031.

Schmidt CQ, Schrezenmeier H, Kavanagh D. 2022. Complement and the prothrombotic state. Blood. 2022 Mar 31;139(13):1954-1972. doi: 10.1182/blood.2020007206.

Loacker L, Kimpel J, Bánki Z, Schmidt CQ, Griesmacher A, Anliker M. 2022. Increased PD-L1 surface expression on peripheral blood granulocytes and monocytes after vaccination with SARS-CoV2 mRNA or vector vaccine. Clin. Chem. Lab. Med. 2022 Oct 18;61(1):e17-e19. doi: 10.1515/cclm-2022-0787.

Wohlgemuth L, Stratmann AEP, Münnich F, Bernhard S, Thomaß BD, Münnich F, Mohamed AOK, Mannes M, Schmidt CQ, Nilsson Ekdahl K, Nilsson B, Fauler M, Föhr KJ, Huber-Lang M, Messerer DAC. 2022. Modulation of neutrophil activity by soluble complement cleavage products - An in-depth analysis. Cells. 2022 Oct 20;11(20):3297. doi: 10.3390/cells11203297.

Nilson R, Lübbers O, Schmidt CQ, Rojewski M, Zeplin PH, Funk W, Schrezenmeier H, Kritzinger A, Kochanek S, Krutzke L. 2022. Hexon modification of human adenovirus type 5 vectors enables efficient transduction of human multipotent mesenchymal stromal cells. Mol. Ther. Methods Clin. Dev. 2022 Mar 7;25:96-110. doi: 10.1016/j.omtm.2022.03.004.

Schmidt CQ, Smith RJH. 2022. Protein therapeutics and their lessons: Expect the unexpected when inhibiting the multi-protein cascade of the complement system. Immunol. Rev. 2023 Jan;313(1):376-401. doi: 10.1111/imr.13164. Epub 2022 Nov 18. PMID: 36398537.

Bechtler C, Koutsogiannaki S, Umnyakova E, Hamid A, Gautam A, Sarigiannis Y, Pouw RB, Lamers C, Rabbani S, Schmidt CQ, Lambris JD, Ricklin D. 2022. Complement-regulatory biomaterial coatings: Activity and selectivity profile of the factor H-binding peptide 5C6. Acta Biomater. 2023 Jan 1;155:123-138. doi: 10.1016/j.actbio.2022.10.055.

Duweb A, Gaiser AK, Stiltz I, El Gaafary M, Simmet T, Syrovets T. 2022. The SC cell line as an in vitro model of human monocytes. J. Leukoc. Biol. 2022 Oct;112(4):659-668. doi: 10.1002/JLB.1A1221-680R.

Lederer AK, Samstag Y, Simmet T, Syrovets T, Huber R. 2022. Complementary medicine usage in surgery: a cross-sectional survey in Germany. BMC Complement Med Ther. 2022 Oct 11;22(1):263. doi: 10.1186/s12906-022-03746-3. Erratum in: BMC Complement Med. Ther. 2022 Nov 19;22(1):304.

Ulrich J, Stiltz S, St-Gelais A, El Gaafary M, Simmet T, Syrovets T, Schmiech M. 2022. Phytochemical composition of Commiphora oleogum resins and their cytotoxicity against skin cancer cells. Molecules. 2022 Jun 17;27(12):3903. doi: 10.3390/molecules27123903.

El Gaafary M, Saber FR, Mahrous EA, Ashour RM, Okba MM, Jin L, Lang SJ, Schmiech M, Simmet T, Syrovets T. 2022. The phloroglucinol calcitrinone A, a novel mitochondria-targeting agent, induces cell death in breast cancer cells. Food Chem. Toxicol. 2022 Feb 25;162:112896. doi: 10.1016/j.fct.2022.112896.

El Gaafary M, Morad SAF, Schmiech M, Syrovets T, Simmet T. 2022. Arglabin, an EGFR receptor tyrosine kinase inhibitor, suppresses proliferation and induces apoptosis in prostate cancer cells. Biomed. Pharmacother. 2022 Dec;156:113873. doi: 10.1016/j.biopha.2022.113873.

Hafner S, Zolk O, Barth H. 2022. COVID-19 pandemic-related adaptations of medical education in clinical pharmacology - impact on students and lecturers at a German university. Naunyn Schmiedebergs Arch. Pharmacol. 2022 Jun;395(6):681-690. doi: 10.1007/s00210-022-02225-3.

Schwarz A, Schmitt R, Einecke G, Keller F, Bode U, Haller H, Guenter HH. 2022. Graft function and pregnancy outcomes after kidney transplantation. BMC Nephrol. 2022 Jan 12;23(1):27. doi: 10.1186/s12882-022-02665-2.

Czock D, Keller F. 2022. Clinical Pharmacokinetics and Pharmacodynamics of Roxadustat. Clin. Pharmacokinet. 2022 Mar;61(3):347-362. doi: 10.1007/s40262-021-01095-x. Epub 2021 Dec 14.