Originalarbeiten

 

  1. An alternative splicing signature defines the basal-like phenotype and predicts worse clinical outcome in pancreatic cancer. Ruta V, Naro C, Pieraccioli M, Leccese A, Archibugi L, Cesari E, Panzeri V, Allgöwer C, Arcidiacono PG, Falconi M, Carbone C, Tortora G, Borrelli F, Attili F, Spada C, Quero G, Alfieri S, Doglioni C, Kleger A, Capurso G, Sette C. Cell Rep Med. 2024 Feb 20;5(2):101411. doi: 10.1016/j.xcrm.2024.101411. Epub 2024 Feb 6. PMID: 38325381; PMCID: PMC10897606. (IF 14,3)
  2. Type 1 Autoimmune Pancreatitis in Europe: Clinical Profile and Response to Treatment. Overbeek KA, Poulsen JL, Lanzillotta M, Vinge-Holmquist O, Macinga P, Demirci AF, Sindhunata DP, Backhus J, Algül H, Buijs J, Levy P, Kiriukova M, Goni E, Hollenbach M, Miksch RC, Kunovsky L, Vujasinovic M, Nikolic S, Dickerson L, Hirth M, Neurath MF, Zumblick M, Vila J, Jalal M, Beyer G, Frost F, Carrara S, Kala Z, Jabandziev P, Sisman G, Akyuz F, Capurso G, Falconi M, Arlt A, Vleggaar FP, Barresi L, Greenhalf B, Czakó L, Hegyi P, Hopper A, Nayar MK, Gress TM, Vitali F, Schneider A, Halloran CM, Trna J, Okhlobystin AV, Dagna L, Cahen DL, Bordin D, Rebours V, Mayerle J, Kahraman A, Rasch S, Culver E, Kleger A, Martínez-Moneo E, Røkke O, Hucl T, Olesen SS, Bruno MJ, Della-Torre E, Beuers U, Löhr JM, Rosendahl J; PrescrAIP Study Group. Clin Gastroenterol Hepatol. 2024 Jan 5:S1542-3565(23)01042-X. doi: 10.1016/j.cgh.2023.12.010. Epub ahead of print. PMID: 38184096. (IF 12,6) 
  3. DNA methylation-associated allelic inactivation regulates Keratin 19 gene expression during pancreatic development and carcinogenesis. Krüger J, Fischer A, Breunig M, Allgöwer C, Schulte L, Merkle J, Mulaw MA, Okeke N, Melzer MK, Morgenstern C, Azoitei N, Seufferlein T, Barth TF, Siebert R, Hohwieler M, Kleger A. J Pathol. 2023 Oct;261(2):139-155. doi: 10.1002/path.6156. (IF 9,88)
  4. Loss of ORP3 induces aneuploidy and promotes bladder cancer cell invasion through deregulated microtubule and actin dynamics. Wang X, Liu J, Azoitei A, Eiseler T, Meessen S, Jiang W, Zheng X, Makori AW, Eckstein M, Hartmann A, Stilgenbauer S, Elati M, Hohwieler M, Kleger A, John A, Zengerling F, Wezel F, Bolenz C, Günes C. Cell Mol Life Sci. 2023 Sep 22;80(10):299. doi: 10.1007/s00018-023-04959-6. (IF 9,02)
  5. Pancreatic acinar heterogeneity hijacks carcinogenesis and homeostasis. Melzer MK, Kleger A. Cell Stem Cell. 2023 Aug 3;30(8):1003-1005. doi: 10.1016/j.stem.2023.07.008. (IF 23,9)
  6. Single-cell profiling of GP2-enriched pancreatic progenitors to simultaneously create acinar, ductal, and endocrine organoids. Merz S, Breunig M, Melzer MK, Heller S, Wiedenmann S, Seufferlein T, Meier M, Krüger J, Mulaw MA, Hohwieler M, Kleger A. Theranostics. 2023 Mar 21;13(6):1949-1973. doi: 10.7150/thno.78323. (IF 11,6)
  7. TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration. Melzer MK, Schirge S, Gout J, Arnold F, Srinivasan D, Burtscher I, Allgöwer C, Mulaw M, Zengerling F, Günes C, Lickert H, Christoffels VM, Liebau S, Wagner M, Seufferlein T, Bolenz C, Moon AM, Perkhofer L, Kleger A. BMC Biol. 2023 Mar 20;21(1):55. doi: 10.1186/s12915-023-01553-x. (IF 7,4)
  8. Toward a Physiologically Relevant 3D Helicoidal-Oriented Cardiac Model: Simultaneous Application of Mechanical Stimulation and Surface Topography. Navaee F, Renaud P, Piacentini N, Durand M, Bayat DZ, Ledroit D, Heub S, Boder-Pasche S, Kleger A, Braschler T, Weder G. Bioengineering (Basel). 2023 Feb 17;10(2):266. doi: 10.3390/bioengineering10020266. (IF 5,0)
  9. A Three-Dimensional Engineered Cardiac In Vitro Model: Controlled Alignment of Cardiomyocytes in 3D Microphysiological Systems. Navaee F, Khornian N, Longet D, Heub S, Boder-Pasche S, Weder G, Kleger A, Renaud P, Braschler T. Cells. 2023 Feb 10;12(4):576. doi: 10.3390/cells12040576. (IF 7,6)
  10. Highly Efficient Cardiac Differentiation and Maintenance by Thrombin-Coagulated Fibrin Hydrogels Enriched with Decellularized Porcine Heart Extracellular Matrix. Navaee F, Renaud P, Kleger A, Braschler T. Int J Mol Sci. 2023 Feb 2;24(3):2842. doi: 10.3390/ijms24032842. (IF 6,2)
  11. Protocol to use de-epithelialized porcine urinary bladder as a tissue scaffold for propagation of pancreatic cells.  Melzer MK, Breunig M, Lopatta P, Hohwieler M, Merz S, Azoitei A, Günes C, Bolenz C, Kleger A. STAR Protoc. 2022 Dec 16;3(4):101869. doi: 10.1016/j.xpro.2022.101869. (IF 1,34)
  12. A Systematic Comparative Study on the Diagnostic Value of Transabdominal Ultrasound in Patients with Pancreatic Cystic Lesions.  Hentschel V, Beckmann J, Kratzer W, Arnold F, Seufferlein T, Walter B, Kleger A, Müller M. J Clin Med. 2022 Oct 19;11(20):6176. doi: 10.3390/jcm11206176. (IF 2,66)
  13. Perioperative or only adjuvant gemcitabine plus nab-paclitaxel for resectable pancreatic cancer (NEONAX)-a randomized phase II trial of the AIO pancreatic cancer group.  Seufferlein T, Uhl W, Kornmann M, Algül H, Friess H, König A, Ghadimi M, Gallmeier E, Bartsch DK, Lutz MP, Metzger R, Wille K, Gerdes B, Schimanski CC, Graupe F, Kunzmann V, Klein I, Geissler M, Staib L, Waldschmidt D, Bruns C, Wittel U, Fichtner-Feigl S, Daum S, Hinke A, Blome L, Tannapfel A, Kleger A, Berger AW, Kestler AMR, Schuhbaur JS, Perkhofer L, Tempero M, Reinacher-Schick AC, Ettrich TJ. Ann Oncol. 2023 Jan;34(1):91-100. doi: 10.1016/j.annonc.2022.09.161. (IF 32,97)
  14. A Methodological Workflow to Analyze Synthetic Lethality and Drug Synergism in Cancer Cells. Gout J, Roger E, Kleger A, Perkhofer L. Methods Mol Biol. 2022;2535:59-72. doi: 10.1007/978-1-0716-2513-2_5. (IF 1,37)
  15. Generating iPSCs with a High-Efficient, Non-Invasive Method-An Improved Way to Cultivate Keratinocytes from Plucked Hair for Reprogramming.  Wüstner LS, Klingenstein M, Frey KG, Nikbin MR, Milazzo A, Kleger A, Liebau S, Klingenstein S. Cells. 2022 Jun 17;11(12):1955. doi: 10.3390/cells11121955. (IF 6,70)
  16. Functional IKK/NF-κB signaling in pancreatic stellate cells is essential to prevent autoimmune pancreatitis. Chan LK, Tsesmelis M, Gerstenlauer M, Leithäuser F, Kleger A, Frick LD, Maier HJ, Wirth T. Commun Biol. 2022 May 27;5(1):509. doi: 10.1038/s42003-022-03371-3. (IF 6,54)
  17. Impaired regulation of PMCA activity by defective CFTR expression promotes epithelial cell damage in alcoholic pancreatitis and hepatitis.  Madácsy T, Varga Á, Papp N, Tél B, Pallagi P, Szabó V, Kiss A, Fanczal J, Rakonczay Z Jr, Tiszlavicz L, Rázga Z, Hohwieler M, Kleger A, Gray M, Hegyi P, Maléth J. Cell Mol Life Sci. 2022 Apr 28;79(5):265. doi: 10.1007/s00018-022-04287-1. (IF 9,26)
  18. HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types, an Budczies J, Kluck K, Beck S, Ourailidis I, Allgäuer M, Menzel M, Kazdal D, Perkhofer L, Kleger A, Schirmacher P, Seufferlein T, Stenzinger A, J. Path Clin Res, doi: 10.1002/cjp2.271 (IF 5,02)
  19. High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development, Krumm J, Sekine K, Samaras P, Brazovskaja A, Breunig M, Yasui R, Kleger A, Taniguchi H, Wilhelm M, Treutlein B, Camp JG, Kuster B. Cell Rep. 2022 Mar 29;38(13):110604. doi: 10.1016/j.celrep.2022.110604. (IF 9,99)
  20. Microbial Spectra and Clinical Outcomes from Endoscopically Drained Pancreatic Fluid Collections: A Descriptive Cohort Study, Hentschel V, Walter B, Harder N, Arnold F, Seufferlein T, Wagner M, Müller M, Kleger A., Antibiotics (Basel). 2022 Mar 21;11(3):420. doi: 10.3390/antibiotics11030420. (IF 4,63)
  21. Functional Genomic Screening in Human Pluripotent Stem Cells Reveals New Roadblocks in Early Pancreatic Endoderm Formation, Krüger J, Breunig M, Pasquini LP, Morawe M, Groß A, Arnold F, Russell R, Seufferlein T, Azoitei N, Kestler HA, Julier C, Heller S, Hohwieler M, Kleger A. Cells. 2022 Feb 8;11(3):582. doi: 10.3390/cells11030582. (IF 6,70)
  22. Organoids at the PUB: The Porcine Urinary Bladder Serves as a Pancreatic Niche for Advanced Cancer Modeling, Melzer MK, Breunig M, Arnold F, Wezel F, Azoitei A, Roger E, Krüger J, Merkle J, Schütte L, Resheq Y, Hänle M, Zehe V, Zengerling F, Azoitei N, Klein L, Penz F, Singh SK, Seufferlein T, Hohwieler M, Bolenz C, Günes C, Gout J, Kleger A. Adv Healthc Mater. 2022 Feb 3:e2102345. doi: 10.1002/adhm.202102345. (IF 9,933)
  23. Differentiation of human pluripotent stem cells into pancreatic duct-like organoids, Breunig M, Merkle J, Melzer MK, Heller S, Seufferlein T, Meier M, Hohwieler M, Kleger A., STAR Protoc. 2021 Dec 8;2(4):100913. doi: 10.1016/j.xpro.2021.100913. (IF 1,34)
  24. Spike residue 403 affects binding of coronavirus spikes to human ACE2.  Zech F, Schniertshauer D, Jung C, Herrmann A, Cordsmeier A, Xie Q, Nchioua R, Prelli Bozzo C, Volcic M, Koepke L, Müller JA, Krüger J, Heller S, Stenger S, Hoffmann M, Pöhlmann S, Kleger A, Jacob T, Conzelmann KK, Ensser A, Sparrer KMJ, Kirchhoff F. Nature Communications 2021 Nov 25;12(1):6855 doi: 10.1038/s41467-021-27180-0. (IF 17,69)
  25. Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation.  Heller S, Li Z, Lin Q, Geusz R, Breunig M, Hohwieler M, Zhang X, Nair GG, Seufferlein T, Hebrok M, Sander M, Julier C, Kleger A#, Costa IG#. Commun Biol. 2021 Nov 17;4(1):1298. doi: 10.1038/s42003-021-02818-3. (IF 6,54)
  26. CDKN2A-Mutated Pancreatic Ductal Organoids from Induced Pluripotent Stem Cells to Model a Cancer Predisposition Syndrome.  Merkle J, Breunig M, Schmid M, Allgöwer C, Krüger J, Melzer MK, Bens S, Siebert R, Perkhofer L, Azoitei N, Seufferlein T, Heller S, Meier M, Müller M, Kleger A#, Hohwieler M.#Cancers (Basel). 2021 Oct 13;13(20):5139. doi: 10.3390/cancers13205139. (IF 6,64)
  27. ONECUT1 mutations and variants in diabetes Philippi A, Heller S, Costa IG, Senée V, Breunig M, Li Z, Kwon G, Russell R, Illing A, Lin Q, Hohwieler M, Degavre A, Zalloua P, Liebau S, Schuster M, Krumm J, Zhang X, Geusz R, Benthuysen JR, Wang A, Chiou J, Gaulton K, Neubauer H, Simon E, Klein T, Wagner M, Nair G, Besse C, Dandine-Roulland C, Olaso R, Deleuze JF, Kuster B, Hebrok M, Seufferlein T, Sander M, Boehm BO, Oswald F, Nicolino M, Julier C, Kleger A#. Nature Medicine2021 Nov;27(11):1928-1940. doi: 10.1038/s41591-021-01502-7. (IF 87,24)
  28. Model systems in gastroenterological research: From animal models to human organoids to the clinic. Arnold F, Kleger A. Pathologe. 2021 Oct 8:1-6. doi: 10.1007/s00292-021-00996-9. (IF 1,01)
  29. Human stem cell-based retina-on-chip as new translational model for validation of AAV retinal gene therapy vectors. Achberger K, Cipriano M, Düchs M, Schön Ch, Michelfelder S, Stierstorfer B, Lamla Th, Kauschke SG, Chuchuy J, Roosz J, Mesch L, Cora V, Pars S, Pashkovskaia N, Corti S, Kleger A, Kreuz S, Maier U, Liebau S#, Loskill P#. Stem Cell reports, 2021 Sep 14;16(9):2242-2256. doi:10.1016/j.stemcr.2021.08.008. (IF 7,76)
  30. Targeting DNA Damage Repair Mechanisms in Pancreas Cancer.  Perkhofer L, Golan T, Cuyle PJ, Matysiak-Budnik T, Van Laethem JL, Macarulla T, Cauchin E, Kleger A, Beutel AK, Gout J, Stenzinger A, Van Cutsem E, Bellmunt J, Hammel P, O'Reilly EM, Seufferlein T. Cancers (Basel). 2021 Aug 24;13(17):4259. doi: 10.3390/cancers13174259. (IF 6,64)
  31. The Selective 5-HT1A Agonist SR57746A Protects Intestinal Epithelial Cells and Enteric Glia Cells and Promotes Mucosal Recovery in Experimental Colitis.  Walldorf J, Porzner M, Neumann M, Joodi G, Niess JH, von Boyen G, Mäder K, Weissbach J, Kleger A, Seufferlein T. Inflamm Bowel Dis. 2021 Aug 21:izab191. doi: 10.1093/ibd/izab191. (IF 5,32)
  32. IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition Bozzo CP, Nchioua R, Volcic M, Krüger J, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Schütz D, Koepke L, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Sauter D, Münch J, Diofano F, Goffinet C, Catanese A, Schön M, Böckers T, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ and Kirchhoff F. Nature Communications. 2021 Jul 28;12(1):4584. doi: 10.1038/s41467-021-24817-y (IF 17,69)
  33. Single-cell-resolved differentiation of human induced pluripotent stem cells into pancreatic duct-like organoids on a microwell chip. Wiedenmann S, Breunig M, Merkle J, von Toerne C, Georgiev T, Moussus M, Schulte L, Seufferlein T, Sterr M, Lickert H, Weissinger SE, Möller P, Hauck SM, Hohwieler M, Kleger A, Meier M. Nat Biomed Eng. 2021 Aug;5(8):897-913. doi: 10.1038/s41551-021-00757-2. (IF 29,23)
  34. Telomerase and Pluripotency Factors Jointly Regulate Stemness in Pancreatic Cancer Stem Cells.  Walter K, Rodriguez-Aznar E, Ferreira MSV, Frappart PO, Dittrich T, Tiwary K, Meessen S, Lerma L, Daiss N, Schulte LA, Najafova Z, Arnold F, Usachov V, Azoitei N, Erkan M, Lechel A, Brümmendorf TH, Seufferlein T, Kleger A, Tabarés E, Günes C, Johnsen SA, Beier F, Sainz B Jr, Hermann PC. Cancers (Basel). 2021 Jun 23;13(13):3145. doi: 10.3390/cancers13133145. (IF 6,64)
  35. Functional Genomic Screening During Somatic Cell Reprogramming Identifies DKK3 as a Roadblock of Organ Regeneration. Arnold F, Mahaddalkar P, Kraus JM, Zhong X, Bergmann W, Srinivasan D, Gout J, Roger E, Beutel A, Zizer E, Tharehalli U, Daiss N, Russell R, Perkhofer L, Oellinger R, Lin Q, Azoitei N, Weiss FU, Lerch MM, Liebau S, Katz SF, Lechel A, Rad R, Seufferlein T, Kestler HA, Ott M, Sharma AD, Hermann P, Kleger A#. Advanced Science 2021 May 13;8(14):2100626. doi: 10.1002/advs.202100626. (IF 17,52)
  36. A prospective feasibility trial to challenge patient-derived pancreatic cancer organoids in predicting treatment response. Beutel A, Schütte L, Scheible J, Roger E, Müller M, Perkhofer L, Kestler A, Kraus JM, Kestler HA, Barth T, Lemke J, Kornmann M, Ettrich T, Gout J, Seufferlein T#, Kleger A#. Cancers 2021 May 21;13(11):2539. doi: 10.3390/cancers13112539 (IF 6,64)
  37. A feedback-loop between telomerase activity and stemness factors regulates PDAC stem cells. Walter K, Rodriguez-Aznar E, Ventura Ferreira MS, Frappart PO, Dittrich T, Tiwary K, Meessen S, Lerma L, Daiss N, Schulte LA, Arnold F, Usachov V, Azoitei N, Erkan M, Lechel A, Brümmendorf TH, Seufferlein T, Kleger A, Tabarés E, Günes C, Beier F, Sainz Jr B, Hermann PC. Cancers 2021 Aug 24;13(17):4259. doi: 10.3390/cancers13174259 (IF 6,64)
  38. Modelling Plasticity and Dysplasia of Pancreatic Ductal Organoids Derived from Human Pluripotent Stem Cells. Breunig M, Merkle J, Wagner M, Melzer M, Barth T, Engleitner T, Krumm J, Wiedenmann S, Cohrs CM, Perkhofer L, Jain G, Krüger J, Hermann PC, Schmid M, Madácsy, Varga A, Griger J, Azoitei N, Müller M, Wessely O, Robey P, Heller, Dantes S, Reichert M, Günes C, Bolenz C, Kuhn F, Maléth J, Speier S, Liebau S, Sipos B, Kuster B, Seufferlein T, Rad R, Meier M, Hohwieler M, Kleger A#. Cell Stem Cell, 2021 Jun 3;28(6):1105-1124.e19. doi: 10.1016/j.stem.2021.03.005.Epub 2021 Apr 28 (IF 24,63)
  39. SARS-CoV-2 variants B.1.351 and B.1.1.248 escape from neutralizing antibodies. Hoffmann M, Arora P, Groß R, Seidel A, Hörnich B, Hahn A, Krüger N, Graichen L, Hofmann-Winkler H, Kempf A, Winkler MS, Schulz S, Jäck H-M, Jahrsdörfer B, Schrezenmeier H, Müller M, Kleger A, Münch J, Pöhlmann S. Cell, 2021 Apr 29;184(9):2384-2393.e12. doi: 10.1016/j.cell.2021.03.036. Epub 2021 Mar 20 (IF 41,52)
  40. A follow-up study of a European IgG4-related disease cohort treated with rituximab. Backhus J, Neumann Ch, Perkhofer L, Schulte LA, Mayer B, Seufferlein T, Müller M, Kleger A#, Journal of Clinical Medicine, 2021 Mar 23;10(6):1329. doi: 10.3390/jcm10061329. (IF 4,96)
  41. Interpreting type 1 diabetes risk with genetics and single-cell epigenomics. Chiou J, Geusz RJ, Okino ML, Han JY, Miller M, Melton R, Beebe E, Benaglio P, Huang S, Korgaonkar K, Heller S, Kleger A, Preissl S, Gorkin DU, Sander M, Gaulton KJ. Nature, 2021 Jun;594(7863):398-402. doi: 10.1038/s41586-021-03552-w. Epub 2021 May 19. (IF 69,50)
  42. Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection: Wettstein L, Weil T, Conzelmann C, Müller JA, Groß R, Hirschenberger M, Seidel A, Klute S, Zech F, Bozzo CP, Preising N, Fois G, Lochbaum R, Knaff PM, Mailänder V, Ständker L, Dietmar Thal R, Schumann C, Stenger S, Kleger A, Lochnit G, Mayer B, Ruiz-Blanco YB, Hoffmann M, Sparrer KMJ, Pöhlmann S, Sanchez-Garcia E, Kirchhoff F, Frick M, & Münch J, Nature Communications, 2021 Mar 19;12(1):1726. doi: 10.1038/s41467-021-21972-0. (IF 17,69)
  43. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth T, Wagner M#, Münch J#, Heller S#, Kleger A#, Nature metabolism, 2021 Feb 3, doi:10.1038/s42255-021-00347-1 (IF 19,95)
  44. RINT1 regulates SUMOylation and the DNA damage response to preserve cellular homeostasis in pancreatic cancer. Arnold F, Gout J, Wiese H, Weissinger S, Roger E, Perkhofer L, Walter K, Scheible J, Prelli-Bozzo C, Lechel A, Ettrich TJ, Azoitei N, Hao L, Fuerstberger A, Kaminska EK, Sparrer KMJ, Rasche V, Wiese S, Kestler HA, Möller P, Seufferlein T, Frappart PO, Kleger A#, Cancer Research, 2021 Feb 2: canres-2633.2020. doi:10.1158/0008-5472 (IF 12,02)
  45. Evidence of SARS-CoV2 Entry Protein ACE2 in the Human Nose and Olfactory Bulb. Klingenstein M, Klingenstein S, Neckel PH, Mack AF, Wagner AP, Kleger A, Liebau S, Milazzo A. Cells Tissues Organs. 2021 Jan 22:1-10. doi: 10.1159/000513040. (IF 2,48)
  46. Generation of Functional Vascular Endothelial Cells and Pericytes from Keratinocyte Derived Human Induced Pluripotent Stem Cells. Pars S, Achberger K, Kleger A, Liebau S, Pashkovskaia N. Cells. 2021 Jan 5;10(1):74. doi: 10.3390/cells10010074. (IF 6,70)
  47. Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell-Derived Intestinal Organoids. Krüger J, Groß R, Conzelmann C, Müller JA, Koepke L, Sparrer KMJ, Weil T, Schütz D, Seufferlein T, Barth TFE, Stenger S, Heller S, Münch J#, Kleger A#. Cell Mol Gastroenterol Hepatol. 2020 Nov 10:S2352-345X(20)30182-X. doi: 10.1016/j.jcmgh.2020.11.003. (IF 7,08)
  48. PDX-derived organoids model in vivo drug response and secrete biomarkers. Huang L, Bockorny B, Paul I, Akshinthala D, Frappart PO, Gandarilla O, Bose A, Sanchez-Gonzalez V, Rouse EE, Lehoux SD, Pandell N, Lim CM, Clohessy JG, Grossman J, Gonzalez R, Del Pino SP, Daaboul G, Sawhney MS, Freedman SD, Kleger A, Cummings RD, Emili A, Muthuswamy LB, Hidalgo M, Muthuswamy SK. JCI Insight. 2020 Nov 5;5(21):e135544. doi: 10.1172/jci.insight.135544. (IF 9,48)
  49. Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock. Halbgebauer R, Karasu E, Braun CK, Palmer A, Braumüller S, Schultze A, Schäfer F, Bückle S, Eigner A, Wachter U, Radermacher P, Resuello RRG, Tuplano JV, Nilsson Ekdahl K, Nilsson B, Armacki M, Kleger A, Seufferlein T, Kalbitz M, Gebhard F, Lambris JD, van Griensven M, Huber-Lang M. Front Immunol. 2020 Aug 26;11:2081. doi: 10.3389/fimmu.2020.02081. (IF 6,42)
  50. Maintenance Therapy for ATM-Deficient Pancreatic Cancer by Multiple DNA Damage Response Interferences after Platinum-Based Chemotherapy. Roger E, Gout J, Arnold F, Beutel AK, Müller M, Abaei A, Barth TFE, Rasche V, Seufferlein T, Perkhofer L#, Kleger A#. Cells. 2020 Sep 16;9(9):2110. doi: 10.3390/cells9092110. (IF 6,60)
  51. Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA. Michel D, Danzer KM#, Groß R, Conzelmann C, Müller JA, Freischmidt A, Weishaupt JH, Heller S, Münch J, Michel M, Stamminger T, Kleger A#, Otto M. J Virol Methods. 2020 Dec;286:113965. doi: 10.1016/j.jviromet.2020.113965. (IF 2,56)
  52. Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer. Gout J, Perkhofer L, Morawe M, Arnold F, Ihle M, Biber S, Lange S, Roger E, Kraus JM, Stifter K, Hahn SA, Zamperone A, Engleitner T, Müller M, Walter K, Rodriguez-Aznar E, Sainz B Jr, Hermann PC, Hessmann E, Müller S, Azoitei N, Lechel A, Liebau S, Wagner M, Simeone DM, Kestler HA, Seufferlein T, Wiesmüller L, Rad R, Frappart PO, Kleger A#. Gut. 2020 Sep 1:gutjnl-2019-319970. doi: 10.1136/gutjnl-2019-319970. (IF 23,05)
  53. IFN-γ treatment protocol for MHC-Ilo/PD-L1+ pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential. Stifter K, Krieger J, Ruths L, Gout J, Mulaw M, Lechel A, Kleger A, Seufferlein T, Wagner M, Schirmbeck R. J Immunother Cancer. 2020 Aug;8(2):e000692. doi: 10.1136/jitc-2020-000692. (IF 13,75)
  54. Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19. Conzelmann C, Müller JA, Perkhofer L, Sparrer KM, Zelikin AN, Münch J, Kleger A#. Clin Med (Lond). 2020 Nov;20(6):e218-e221. doi: 10.7861/clinmed.2020-0351. (IF 2,66)
  55. Serum IgG4 levels outperform IgG4/IgG RNA ratio in differential diagnosis of IgG4-related disease. Schulte LA, Arnold F, Siegel F, Backhus J, Beyer G, Weiss FU, Perkhofer L, Beutel A, Seufferlein T, Müller M#,  Kleger A#. JHEP Rep. 2020 Jun 3;2(4):100135. doi: 10.1016/j.jhepr.2020.100135. (IF 8,59)
  56. Transcutaneous carbon dioxide monitoring as a valid complementary method in acute respiratory failure. Perkhofer L, Strobel A, Gagiannis D, Seufferlein T, Schmidt K, Mayer B, Kleger A#, Müller M#. Eur Respir J. 2020 Dec 10;56(6):2002137. doi: 10.1183/13993003.02137-2020. (IF 16,67)
  57. Pancreatic cancer-derived organoids - a disease modeling tool to predict drug response. Frappart PO, Walter K, Gout J, Beutel AK, Morawe M, Arnold F, Breunig M, Barth TF, Marienfeld R, Schulte L, Ettrich T, Hackert T, Svinarenko M, Rösler R, Wiese S, Wiese H, Perkhofer L, Müller M, Lechel A, Sainz B Jr, Hermann PC, Seufferlein T, Kleger A.# United European Gastroenterol J. 2020 Jun;8(5):594-606. doi: 10.1177/2050640620905183. (IF 4,62)
  58. Human peptide α-defensin-1 interferes with Clostridioides difficile toxins TcdA, TcdB, and CDT. Fischer S, Ückert AK, Landenberger M, Papatheodorou P, Hoffmann-Richter C, Mittler AK, Ziener U, Hägele M, Schwan C, Müller M, Kleger A, Benz R, Popoff MR, Aktories K, Barth H. FASEB J. 2020 May;34(5):6244-6261. doi: 10.1096/fj.201902816R. (IF 5,19)
  59. Etiology and Morphology Impact on the Clinical Course of Chronic Pancreatitis. Perkhofer L, Besold T, Schmidberger J, Seufferlein T, Hann A, Müller M#, Kleger A#. Digestion. 2020 Feb 11:1-7. doi: 10.1159/000505646. (IF 2,57)
  60. Genotyping of circulating tumor DNA in cholangiocarcinoma reveals diagnostic and prognostic information. Ettrich TJ, Schwerdel D, Dolnik A, Beuter F, Blätte TJ, Schmidt SA, Stanescu-Siegmund N, Steinacker J, Marienfeld R, Kleger A, Bullinger L, Seufferlein T, Berger AW. Sci Rep. 2019 Sep 13;9(1):13261. doi: 10.1038/s41598-019-49860-0 (IF 4,99)
  61. Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks. Perkhofer L, Engler M, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A#, Frappart PO.#Stem Cells Int. 2019 May 19;2019:2079742. doi: 10.1155/2019/2079742. (IF 4,81)
  62. A Blood-Based Multi Marker Assay Supports the Differential Diagnosis of Early-Stage Pancreatic Cancer. Berger AW, Schwerdel D, Reinacher-Schick A, Uhl W, Algül H, Friess H, Janssen KP, König A, Ghadimi M, Gallmeier E, Bartsch DK, Geissler M, Staib L, Tannapfel A, Kleger A, Beutel A, Schulte LA, Kornmann M, Ettrich TJ, Seufferlein T. Theranostics. 2019 Feb 12;9(5):1280-1287. doi: 10.7150/thno.29247 (IF 11,55)
  63. Thirty-eight-negative-kinase-1 is a major mediator of trauma-induced intestinal injury and multi-organ failure. Armacki M, Trugenberger AK, Ellwanger AK, Eiseler T, Schwerdt C, Bettac L, Langgartner D, Azoitei N, Halbgebauer R, Groß R, Barth T, Lechel A, Walter BM, Kraus JM, Wiegreffe Ch, Grimm J, Scheffold A, Schneider MR, Peuker K, Zeißig S, Britsch S, Rose-John S, Vettorazzi S, Wolf E, Tannapfel A, Steinestel K, Reber S, Walther P, Kestler HA, Radermacher P, Barth TF, Huber-Lang M, Kleger A#, Seufferlein T#, Journal of Clinical Investigation, 2018 Nov 1;128(11):5056-5072. (IF 19,45)
  64. YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion. Tharehalli U, Svinarenko M, Kraus JM, Kühlwein SD, Szekely R, Kiesle U, Scheffold A, Barth TFE, Kleger A, Schirmbeck R, Kestler HA, Seufferlein T, Oswald F, Katz SF, Lechel A. Int J Mol Sci. 2018 Nov 29;19(12):3801. doi: 10.3390/ijms19123801. (IF 5,54)
  65. Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication. di Masi A, Leboffe L, Polticelli F, Tonon F, Zennaro C, Caterino M, Stano P, Fischer S, Hägele M, Müller M, Kleger A, Papatheodorou P, Nocca G, Arcovito A, Gori A, Ruoppolo M, Barth H, Petrosillo N, Ascenzi P, Di Bella S. J Infect Dis. 2018 Sep 22;218(9):1424-1435 (IF 5,22)
  66. Genetic Biopsy for Prediction of Surveillance Intervals after Endoscopic Resection of Colonic Polyps: Results of the GENESIS Study. Berger AW, Raedler K, Langner C, Ludwig L, Dikopoulos N, Becker KF, Slotta-Huspenina J, Quante M, Schwerdel D, Perkhofer L, Kleger A, Zizer E, Oswald F, Seufferlein T, Meining A. United European Gastroenterol J. 2018 Mar;6(2):290-299. (IF 3,49)
  67. Targeted deep sequencing of circulating tumor DNA in metastatic pancreatic cancer. Berger A, Schwerdel D, Ettrich T, Hann A, Schmidt S, Kleger A, Marienfeld R, Seufferlein T. Oncotarget, 2017 Dec 16;9(2):2076-2085. (IF 3,33)
  68. Reprogramming to pluripotency does not require transition through a primitive streak-like state. Raab S, Klingenstein M, Möller A, Illing A, Tosic J, Breunig M, Kuales G, Linta L, Seufferlein T, Arnold SJ, Kleger A#, Liebau S#,  Sci rep, 2017 Nov 29;7(1):16543. (IF 4,99)
  69. Expanding the mutational spectrum in Johanson-Blizzard syndrome: identification of whole exon deletions and duplications in the UBR1 gene by multiplex ligation-dependent probe amplification analysis. Sukalo M, Schäflein E, Schanze I, Everman DB, Rezaei N, Argente J, Lorda-Sanchez I, Deshpande C, Takahashi T, Kleger A, Zenker M. Mol Genet Genomic Med. 2017 Nov;5(6):774-780 (IF 2,18)
  70. ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage. Perkhofer L, Schmitt A, Romero Carrasco MC, Ihle M, Hampp S, Ruess DA, Hessmann E, Russell R, Lechel A, Azoitei N, Lin Q, Liebau S, Hohwieler M, Bohnenberger H, Lesina M, Algül H, Gieldon L, Schröck E, Gaedcke J, Wagner M, Wiesmüller L, Sipos B, Seufferlein T, Reinhardt HC, Frappart PO#, Kleger A#. Cancer Res. 2017 Oct 15;77(20):5576-5590. doi: 10.1158/0008-5472. (IF 12,03)
  71. Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells.Ernst K, Schmid J, Beck M, Hägele M, Hohwieler M, Hauff P, Ückert AK, Anastasia A, Fauler M, Jank T, Aktories K, Popoff MR, Schiene-Fischer C, Kleger A, Müller M, Frick M, Barth H. Sci Rep. 2017 Jun 2;7(1):2724. doi: 10.1038/s41598-017-02882-y. (IF 4,99)
  72. Treatment monitoring in metastatic colorectal cancer patients by quantification and KRAS genotyping of circulating cell-free DNA. Berger AW, Schwerdel D, Welz H, Marienfeld R, Schmidt SA, Kleger A, Ettrich TJ, Seufferlein T. PLoS One. 2017 Mar 22;12(3):e0174308. doi: 10.1371/journal.pone.0174308 (IF 3,24)
  73. Glutamic acid decarboxylase and islet antigen 2 antibody profiles in people with adult-onset diabetes mellitus: a comparison between mixed ethnic populations in Singapore and Germany. Ong YH, Koh WCA, Ng ML, Tam ZY, Lim SC, Boehm BO; Adult-Onset Autoimmune Diabetes Mellitus Consortium (ADAMS). Collaborators: Blagieva R, Brückel J, Claudi-Boehm S, Haak T, Haenle M, Höpfer S, Jütting G, Kleger A, Kratzer W, Kurkhaus A, Lippmann-Grob B, Manfras B, Merger S, Rosinger S, Schilling S, Seufferlein T, Sing R, Trischler G, Ali Y, Bee YM, Boehm J, Chew DEK, Chia KS, Dalan R, Khoo CM, Lee ES, Leow MK, Lim SC, Ng SP, Sim X, Srinivasan DK, Sum CF, Tai ES, Tam ZY, Tan WE, Tavintharan S, Toh MP. Diabet Med. 2017 Mar 28. doi: 10.1111/dme.13358. (IF 4,35)
  74. Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling. Hohwieler M, Illing A, Hermann PC, Mayer T, Stockmann M, Perkhofer L, Eiseler T, Antony JS, Müller M, Renz S, Kuo CC, Lin Q, Sendler M, Breunig M, Kleiderman SM, Lechel A, Zenker M, Leichsenring M, Rosendahl J, Zenke M, Sainz B Jr, Mayerle J, Costa IG, Seufferlein T, Kormann M, Wagner M, Liebau S#, Kleger A.#Gut. 2016 Sep 15. pii: gutjnl-2016-312423. (IF 23,05)
  75. Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness. Perkhofer L, Walter K, Costa IG, Carrasco MC, Eiseler T, Hafner S, Genze F, Zenke M, Bergmann W, Illing A, Hohwieler M, Köhntop R, Lin Q, Holzmann KH, Seufferlein T, Wagner M, Liebau S, Hermann PC#, Kleger A#, Müller M. Stem Cell Res. 2016 Sep;17(2):367-378. doi: 10.1016/j.scr.2016.08.007. (IF 2,02)
  76. Open Surgical versus Minimal Invasive Necrosectomy of the Pancreas-A Retrospective Multicenter Analysis of the German Pancreatitis Study Group. Rasch S, Phillip V, Reichel S, Rau B, Zapf C, Rosendahl J, Halm U, Zachäus M, Müller M, Kleger A, Neesse A, Hampe J, Ellrichmann M, Rückert F, Strauß P, Arlt A, Ellenrieder V, Gress TM, Hartwig W, Klar E, Mössner J, Post S, Schmid RM, Seufferlein T, Siech M, Werner J, Will U, Algül H. PLoS One. 2016 Sep 26;11(9):e0163651. doi: 10.1371/journal.pone.0163651. (IF 3,24)
  77. Circulating cell-free DNA is a reliable tool to detect hot spot mutations in intraductal papillary mucinous neoplasms of the pancreas. Berger A, Schwerdel D, Costa IG, Hackert T, Strobel O, Lam S, Barth T, Schröppel B, Meining A, Büchler MW, Zenke M, Hermann PC, Seufferlein T#, Kleger A#. Gastroenterology, 2016, Aug;151(2):267-70. (IF 33,88)
  78. Cortactin is a scaffolding platform for the E-cadherin adhesion complex and is regulated by protein kinase D1 phosphorylation. Sroka R, Van Lint J, Katz SF, Schneider MR, Kleger A, Paschke S, Seufferlein T, Eiseler T. J Cell Sci. 2016 Jun 15;129(12):2416-29. doi: 10.1242/jcs.184721. (IF 5,35)
  79. „Miniguts“ from plucked human hair meet Crohn´s disease. Hohwieler M1, Renz S, Liebau S, Lin Q, Lechel A, Klaus J, Perkhofer L, Zenke M, Seufferlein T, Illing A, Müller M, Kleger A#ZGastroenterol, 2016,  2016 Aug;54(8):748-59 (IF 2,00)
  80. A dynamic role of Tbx3 in the pluripotency circuitry. Russell R, Ilg M, Lin Q, Wu G, Linta L, Hohwieler M, Lechel A, Bergmann W, Kumar PP, Klingenstein M, Sakk O, Raab S, Moon A, Zenke M, Seufferlein T, Schöler H, Illing A, Liebau S, Kleger A#. Stem Cell Reports, 2015 Dec 8;5(6):1155-70. (IF 7,76)
  81. TBX3 knockdown decreases reprogramming efficiency of human cells. Klingenstein M, Raab S, Achberger K, Kleger A#, Liebau S#, Linta L#. Stem Cells Int., 2016;2016:6759343. (IF 4,81)
  82. Loss of ATM accelerates pancreatic cancer formation and Epithelial-Mesenchymal-Transition. Russell R, Perkhofer L, Liebau S, Lin Q, Lechel A, Feld FM, Zenke M, Illing A, Hartmann D, von Figura G, Weissinger SE, Rudolph KL, Möller P, Lennerz JK, Seufferlein T, Wagner M#, Kleger A#.Nature Communications, 2015 Jul 29;6:7677. (IF 17,69)
  83. A time frame permissive for Protein Kinase D2 activity to direct angiogenesis in mouse embryonic stem cells. Müller M, Schröer S, Azoitei N, Eiseler T, Bergmann W, Köhntop R, Lin L, Zenke M, Genze F, Weidgang C, Seufferlein T, Liebau S#, Kleger A#.Sci Rep, 2015 Jul 7;5:11742. doi: 10.1038/srep11742. (IF 4,9)
  84. Self-expandable metal stents for persisting esophageal variceal bleeding after band ligation or injection-therapy: A retrospective study. Müller M, Seufferlein T, Wagner M, Kleger A#. PLoS One, 2015 Jun 22;10(6):e0126525. (IF 3,24)
  85. TBX3 Directs Cell-Fate Decision toward Mesendoderm. Weidgang CE, Russell R, Tata PR, Kühl SJ, Illing A, Müller M, Lin Q, Brunner C, Boeckers TM, Bauer B, Kartikasari AER, Guo Y, Radenz M, Bernemann C, Weiß M, Seufferlein S, Zenke M, Iacovino M, Kyba M, Schöler HR, Kühl M, Liebau S#, and Kleger A#. Stem Cell Reports, 2013 Aug 29;1(3):248-65. (IF 7,76)
  86. Absence of FLICE-Inhibitory Protein Is a Novel Independent Prognostic Marker for Very Short Survival in Pancreatic Ductal Adenocarcinoma. Schmid SJ, Glatzel MC, Welke C, Kornmann M, Kleger A, Barth TFE, Fulda S, Lennerz JK, and Möller. Pancreas, 2013, Oct;42(7):1114-9. (IF 2,16)
  87. Definitive Endoderm Formation from Plucked Human Hair-Derived Induced Pluripotent Stem Cells and SK Channel Regulation. Illing A, Stockmann M, Telugu NS, Linta L, Russell R, Müller M, Seufferlein T, Liebau S#, Kleger A#. Stem Cells Int, 2013;2013:360573. (IF 4,81)
  88. Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny. Linta L, Stockmann M, Lin Q, Lechel A, Proepper Ch, Boeckers TM, Kleger A#, Liebau L#. Stem Cells Int, 2013, 2013:784629. IF 4,81)
  89. Calcium activated potassium channel expression during human iPS cell-derived neurogenesis. Linta L, Boeckers TM, Kleger A#, Liebau S#. Ann Anat. 2013 Mar 28. (IF 2,34)
  90. Increased Reprogramming Capacity of Mouse Liver Progenitor Cells, Compared With Differentiated Liver Cells, Requires the BAF Complex. Kleger A#, Mahaddalkar P, Katz SF, Lechel A, Ju JY, Loya K, Lin Q, Hartmann D, Liebau S, Kraus J, Cantz T, Kestler HA, Zaehres H, Schöler H, Rudolph KL#. Gastroenterology. 2012 Apr;142(4):907-17. (IF 33,88)
  91. Developmental and functional nature of human iPSC derived motoneurons. Stockmann M, Linta L, Föhr KJ, Boeckers A, Ludolph AC, Kuh GF, Udvardi PT, Proepper C, Storch A, Kleger A, Liebau S, Boeckers TM. Stem Cell Reviews and Reports, 2013 Aug;9(4):475-92. (IF 5,31)
  92. Ca2+-activated K+-Channels - New Tools to induce Cardiac Commitment from Pluripotent Stem Cells in Mice and Men. Müller M*, Stockmann M*, Malan D, Wolheim A, Tischendorf M, Linta L, Katz SF, Lin Q, Latz S, Brunner C, Wobus AM, Zenke M, Wartenberg M, Boeckers TB, von Wichert G, Fleischmann BF, Liebau S#, Kleger A#. Stem Cell Reviews and Reports, 2012 Sep;8(3):720-40.  (IF 5,31)
  93. An inducible expression system of the calcium activated potassium channel 4 to study the differential impact on embryonic stem cells. Liebau S, Tischendorf M, Ansorge D, Linta L, Stockmann M, Weidgang C, Iacovino M, Boeckers T, Kyba M, Kleger A. Stem Cells Int. 2011;2011:456815. IF 4,81)
  94. Protein kinase D2 is a novel regulator of glioblastoma growth and tumor formation. Azoitei N, Kleger A, Schoo N, Thal D, Brunner C, Pusapati GV, Filatova A, Genze F, Möller P, Acker T, Kuefer R, Van Lint J, Baust H, Adler G, Seufferlein T. Neuro Oncol. 2011 Jul;13(7):710-24. (IF 13,02)
  95. Rat embryonic fibroblasts improve reprogramming of human keratinocytes into induced pluripotent stem cells. Linta L, Stockmann M, Böckers A, Böckers TM, Kleger A# and Liebau S#. Stem Cells Dev. 2012 Apr 10;21(6):965-76. (IF 4,39)
  96. Telomerase gene mutations are associated with cirrhosis formation. Hartmann D, Srivastava U, Thaler M, Kleinhans KN, N'kontchou G, Scheffold A, Bauer K, Kratzer RF, Kloos N, Katz SF, Song Z, Begus-Nahrmann Y, Kleger A, von Figura G, Strnad P, Lechel A, Günes C, Potthoff A, Deterding K, Wedemeyer H, Ju Z, Song G, Xiao F, Gillen S, Schrezenmeier H, Mertens T, Ziol M, Friess H, Jarek M, Manns MP, Beaugrand M, Rudolph KL. Hepatology. 2011 May;53(5):1608-17. (IF 17,42)
  97. An SK3 Channel/nWASP/Abi-1 complex is involved in early neurogenesis. Liebau S, Steinestel J, Linta L, Kleger A, Storch A, Schoen M, Steinestel K, Proepper C, Bockmann J, Schmeisser MJ, Boeckers TM. PLoS One. 2011 Mar;6(3):e14599. (IF 3,24)
  98. Regeneration of the exocrine pancreas is delayed in telomere-dysfunctional mice. von Figura G, Wagner M, Nalapareddy K, Hartmann D, Kleger A, Adler G, Rudolph KL. PLoS One. 2011 Feb 22;6(2):e17122. (IF 3,24)
  99. Protein kinase D2 is an essential regulator of murine myoblast differentiation. Kleger A, Loebnitz C, Pusapati GV, Müller M, Tümpel S, Illing A, Hartmann D, Brunner C, Liebau S, Adler G, Seufferlein T. PLoS One. 2011 Jan 27;6(1):e14599.  (IF 3,24)
  100. Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Kleger A, Seufferlein T, Malan D, Tischendorf M, Storch A, Wolheim A, Protze S, Porzner M, Proepper C, Brunner C, Katz SF, Pusapati GV, Bullinger L, Köhntopp R, Giehl K, Spyrantis A, Wittekindt O, Lin Q, Zenke M, Fleischmann BK, Wartenberg M, Wobus AM, BoeckersTM and Liebau S. Circulation. 2010 Nov 2;122(18):1823-36 (IF 38,91)
  101. Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours. Azoitei N, Kleger A, Pusapati GV, Möller P, Küfer R, Genze F, Wagner M, van Lint J, Adler G, Seufferlein T. GUT. 2010 Oct;59(10):1316-30. (IF 23,05)
  102. The bioactive lipid sphingosylphosphorylcholine induces differentiation of mouse embryonic stem cells and human promyelocytic leukaemia cells. Kleger A, Busch T, Liebau S, Prelle K, Paschke S, Beil M, Rolletschek A, Wobus AM, Wolf E, Adler G, Seufferlein T. Cell Signal. 2007 Feb;19(2):367-77 (IF 5,71)
  103. Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cells. Herrmann A, Maisel M, Liebau S, Gerlach M, Kleger A, Schwarz J, Kim KS, Antoniadis G, Lerche H, Storch A. J Neurochem. 2006; 98 (2): 629-40. (IF 5,37)

Übersichtsarbeiten

 

  1. SARS-Cov-2 vaccination is safe in autoimmune pancreatitis patients.Perkhofer L, Kilani K, Wieser Ä, Seufferlein T, Kleger P, Mueller M, Kleger A. United European Gastroenterol J. 2024 Feb;12(1):159-161. doi: 10.1002/ueg2.12526. Epub 2024 Jan 5. PMID: 38180459; PMCID: PMC10859700. (IF 6,8) 
  2. Symptoms and Management of Aseptic Liver Abscesses. Hafner S, Seufferlein T, Kleger A, Müller M. Z Gastroenterol. 2023 Oct 12. English. doi: 10.1055/a-2075-5082. (IF 1,30)
  3. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Mastracci TL, Apte M, Amundadottir LT, Alvarsson A, Artandi S, Bellin MD, Bernal-Mizrachi E, Caicedo A, Campbell-Thompson M, Cruz-Monserrate Z, El Ouaamari A, Gaulton KJ, Geisz A, Goodarzi MO, Hara M, Hull-Meichle RL, Kleger A, Klein AP, Kopp JL, Kulkarni RN, Muzumdar MD, Naren AP, Oakes SA, Olesen SS, Phelps EA, Powers AC, Stabler CL, Tirkes T, Whitcomb DC, Yadav D, Yong J, Zaghloul NA, Pandol SJ, Sander M. Diabetes. 2023 Apr 1;72(4):433-448. doi: 10.2337/db22-0942.
  4. The application of pancreatic cancer organoids for novel drug discovery.Melzer MK, Resheq Y, Navaee F, Kleger A. Expert Opin Drug Discov. 2023 Mar 26:1-16. doi: 10.1080/17460441.2023.2194627. (IF 5,73)
  5. COVID-19 and diabetes - where are we now?  Groß R, Kleger A. Nat Metab. 2022 Dec;4(12):1611-1613. doi: 10.1038/s42255-022-00691-w. (IF 19,95)
  6. Acute pancreatitis: Murine model systems unravel disease-modifying genes with potential implications for diagnostics and patient stratification.  Melzer MK, Kleger A. United European Gastroenterol J. 2022 Sep;10(7):618-619. doi: 10.1002/ueg2.12272. (IF 4,62)
  7. State-matched organoid models to fight pancreatic cancer. Melzer MK, Roger E, Kleger A.Trends Cancer. 2022 Mar 31:S2405-8033(22)00069-3. doi: 10.1016/j.trecan.2022.03.003 (IF: 7,47)
  8. Discussion: Current Multimodality Treatment Options in Pancreatic Cancer in Clinical Practice - What Is the Future Impact of Molecular Biological Profiling? Kleger A, Ellenrieder V, Friess H, Michl P, Schneider M, Yang Y, Kornmann M., Visc Med. 2022 Feb;38(1):49-55. doi: 10.1159/000521847. (IF 1,43)
  9. Editorial: Multimodality Treatment in Pancreatic Ductal Adenocarcinoma - Current Options and the Future Impact of Molecular Biological Profiling, Kornmann M, Kleger A.Visc Med. 2022 Feb;38(1):1-3. doi: 10.1159/000521419. (IF 1,43)
  10. S3-Leitlinie Pankreatitis – Leitlinie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – September 2021 – AWMF Registernummer 021-003. Beyer G, Hoffmeister A, Michl P, Gress TM, Huber W, Algül H, Neesse A, Meining A, Seufferlein TW, Rosendahl J, Kahl S, Keller J, Werner J, Friess H, Bufler P, Löhr MJ, Schneider A, Lynen Jansen P, Esposito I, Grenacher L, Mössner J, Lerch MM, Mayerle J; Z Gastroenterol. 2022 Mar;60(3):419-521. doi: 10.1055/a-1735-3864. (IF 2,00)
  11. SARS-CoV-2 and the digestive tract - Organoids to model gastrointestinal infection.Hentschel V, Groß R, Krüger J, Münch J, Müller M, Kleger A. Z Gastroenterol.2021 Nov;59(11):1205-1213. doi: 10.1055/a-1500-8420.Epub 2021 Jul 26. (IF 2,00)
  12. Human Pluripotent Stem Cells Go Diabetic: A Glimpse on Monogenic Variants.  Heller S, Melzer MK, Azoitei N, Julier C, Kleger A. Front Endocrinol (Lausanne). 2021 May 17;12:648284. doi: 10.3389/fendo.2021.648284. (IF 3,67)
  13. Dissecting cancer cell synthetic lethal and synergistic vulnerabilities. Gout J, Roger E, Kleger A#, Perkhofer L#. Methods in Molecular Biology (Springer Nature) (IF 1,37)
  14. Enteropathogenic Infections: Organoids Go Bacterial. Hentschel V, Arnold F, Seufferlein T, Azoitei N, Kleger A#, Müller M#. Stem Cells Int. 2021 Jan 7;2021:8847804. doi: 10.1155/2021/8847804. (IF 4,81)
  15. From Hair to iPSCs-A Guide on How to Reprogram Keratinocytes and Why. Klingenstein S, Klingenstein M, Kleger A, Liebau S. Curr Protoc Stem Cell Biol. 2020 Dec;55(1):e121. doi: 10.1002/cpsc.121. (IF 1,92)
  16. DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives. Perkhofer L, Gout J, Roger E, Kude de Almeida F, Baptista Simões C, Wiesmüller L, Seufferlein T#, Kleger A#. Gut. 2020 Aug 27:gutjnl-2019-319984. doi: 10.1136/gutjnl-2019-319984. (IF 23,05)
  17. An Immunological Glance on Pancreatic Ductal Adenocarcinoma. Melzer MK, Arnold F, Stifter K, Zengerling F, Azoitei N, Seufferlein T, Bolenz C, Kleger A. Int J Mol Sci. 2020 May 8;21(9):3345. doi: 10.3390/ijms21093345. (IF 5,54)
  18. Stem Cell Derived Organoids in Human Disease and Development. Liebau S, Russ HA, Kleger A. Stem Cells Int. 2019 Nov 7;2019:7919427. doi: 10.1155/2019/7919427. (IF 4,81)
  19. Importance of organoids for personalized medicine. Perkhofer L, Frappart PO, Müller M#, Kleger A#. Per Med. 2018 Nov;15(6):461-465. doi: 10.2217/pme-2018-0071.(IF 2,51)
  20. Organoidomics - falling star or new galaxy in pancreatic cancer? Seufferlein T, Kleger A. Nature Rev Gastroenterol Hepatol. 2018 Jul 25. (IF 13,14)
  21. IgG4-Related Diseases in the Gastrointestinal Tract: Clinical Presentation, Diagnosis and Treatment Challenges. Backhus J, Seufferlein T, Perkhofer L, Hermann PC, Kleger A. Digestion. 2018 Nov 1:1-140 (IF 2,57).
  22. Precision medicine meets the DNA damage response in pancreatic cancer. Perkhofer L, Illing A, Gout J, Frappart PO, Kleger A. Oncoscience. 2018 Feb 22;5(1-2):6-8 (IF 1,42)
  23. [Cystic pancreatic tumors: diagnostics and new biomarkers].Berger AW, Seufferlein T, Kleger A. Chirurg. 2017 Aug 22. doi: 10.1007/s00104-017-0493-1. Review. German. (IF 0,84)
  24. IgG4-assoziierte Erkrankungen und Autoimmunpankreatitis. Backhus J, Seufferlein T, Kleger A. Gastroenterologie up2date, Ausgabe 03, September 2017 (IF 2,00)
  25. S-1: changing the facets of adjuvant chemotherapy in pancreatic cancer? Perkhofer L, Ettrich TJ, Kleger A. Transl Cancer Res 2016 (IF 1,24)
  26. Stem cell-based retina models. Achberger K, Haderspeck JC, Kleger A, Liebau S. Adv Drug Deliv Rev. 2019 Feb 1;140:33-50. doi: 10.1016/j.addr.2018.05.005. (IF 15,47)
  27. Stem cell-derived organoids to model gastrointestinal facets of cystic fibrosis. Hohwieler M, Perkhofer L, Liebau S, Seufferlein T, Müller M, Illing A, Kleger A#, United European Gastroenterol J. 2017 Aug;5(5):609-624. (IF 4,62)
  28. [IgG4-associated diseases: State of the art]. Kleger A, Seufferlein T. Radiologe. 2016 Dec;56(12):1035-1042. German. (IF 0,52)
  29. Kleger A. United European Gastroenterol J. 2016 Feb;4(1):154-5. doi: 10.1177/1468797616630162.(IF 4,62)
  30. The role of pluripotency factors to drive stemness in gastrointestinal cancer. Müller M, Hermann PC, Liebau S, Weidgang C, Seufferlein T, Kleger A#, Perkhofer L#. Stem Cell Res. 2016 Feb 3;16(2):349-357. (IF 2,02)
  31. Lost but still missed: A New Chapter about TBX3 in pluripotency and fate decision. Ilg M, Liebau S, Kleger A. J Cell Sign, 1:105. 2016, doi:10.4172/jcs.1000105 (IF 4,31)
  32. Pluripotency Factors on Their Lineage Move. Weidgang CE, Seufferlein T, Kleger A, Mueller M. Stem Cells Int. 2016;2016:6838253. (IF 4,81)
  33. Factors Regulating Stem Cell Biology in Development and Disease. Liebau S, Gadue P, Nalapareddy K, von Figura G, Kleger A. Stem Cells Int. 2016;2016:7170642. (IF 4,81)
  34. Developmental pathways direct pancreatic cancer initiation from its cellular origin. Reichert M, Blume K, Kleger A, Hartmann D, von Figura G. Stem Cells Int., 2016;2016:9298535. (IF 4,81)
  35. A fresh look on T-box factor action in the early embryogenesis. Maíra Bertolessi Lourenço, Leonard Linta, Thomas Seufferlein, Kleger A#, Liebau S#. Stem Cells Dev. 2015 Aug 15;24(16):1833-51. (IF 4,39)
  36. The role of telomeres in liver disease. Sunami Y, von Figura G, Kleger A, Strnad P, Hüser N, Hartmann D. Prog Mol Biol Transl Sci. 2014;125:159-72. (IF 3,62)
  37. IgG4-assoziierte Autoimmunerkrankungen–Diagnostik und Therapie einer Erkrankung mit vielen unterschiedlichen Manifestationen. Kleger A, Seufferlein T, Wagner M, Tannapfel A, Hoffmann T, Mayerle J. Dtsch Arztebl Int. 2015 Feb 20;112(8):128-35. (IF 5,59)
  38. Pharmakotherapie beim Pankreaskarzinom – ein aktueller Über- und Ausblick. Kleger A, Seufferlein T. Arzneimitteltherapie, 2014; 32:274-82.
  39. Smarter drugs emerging in pancreatic cancer therapy. Kleger A, Perkhofer L, Seufferlein T. Annals of Oncology, 2014, ul;25(7):1260-1270. (IF 32,97) 
  40. Induced pluripotent stem cells – a new resource for modern medicine. Liebau S, Stockmann M, Illing A, Seufferlein T, Kleger A. Internist (Berl). 2014 Apr;55(4):460-9. (IF 0,51)
  41. Recurrent Clostridium difficile infection: Treatment with duodenal infusion of donor feces. Seufferlein T, Kleger A, Nitschmann S. Internist (Berl). 2014 Apr;55(4):455-9. (IF 0,51)
  42. Stem cells and ion channels. Liebau S, Kleger A, Levin M, Yu SP. Stem Cells Int. 2013;2013:238635. (IF 4,81)
  43. A Hierarchy in Reprogramming Capacity in Different Tissue Microenvironments: What We Know and What We Need to Know. Liebau S, Mahaddalkar PU, Kestler HA, Illing A, Seufferlein T, Kleger A. Stem Cells Dev. 2013 Mar 1;22(5):695-706 [Epub 2013 Jan 5.] (IF 4,39)
  44. Stromareaktion im Pankreaskarzinom – “winning the hype or losing the hope?”. Kleger A, Seufferlein T. Journal Onkologie. 2013.
  45. The potential of iPS cells in synucleinopathy research. Linta L, Stockmann M, Boeckers TM, Kleger A, Liebau S. Stem Cells Int. 2012;2012:629230. (IF 4,81)
  46. Transplantation adulter Gewebsstammzellen – ein weiterer Schritt in die richtige Richtung. Kleger A. Naturwissenschaftliche Rundschau. 2012.
  47. Calcium-activated potassium channels, cardiogenesis of pluripotent stem cells, and enrichment of pacemaker-like cells. Kleger A, Liebau S. Trends Cardiovasc Med. 2011 Apr;21(3):74-83. (IF 4,46)
  48. The impact of bioactive lipids on cardiovascular development. Kleger A * #, Liebau S *, Lin Q, Seufferlein T*. Stem Cells Int. 2011;2011:916180. (IF 4,81)

  49.  

    Fallberichte

  50. Aseptic Liver Abscesses as an Exceptional Finding in Cogan's Syndrome. Hafner S, Seufferlein T, Kleger A, Müller M. Hepatology. 2020 Sep 11. doi: 10.1002/hep.31547.
  51. An exceptional cause of epigastric pain. Schulte-Kemna L, Kornmann M, Kleger A. Gastroenterology, 2016 Jun;150(7):e1-e2. doi: 10.1053/j.gastro.2016.02.002.
  52. A rare cause of upper GI bleeding and wasting disease. van Erp RJ, Schröppel B, Barth TF, Seufferlein T, Schmidt SA, Meining A, Kleger A. GUT. 2016 May;65(5):787, 881. doi: 10.1136/gutjnl-2015-310404.
  53. Case report: Fecal transplantation therapy in refractory clostridium difficile colitis. Kleger A, Schnell J, Essig A, Wagner M, Bommer M, Seufferlein T, Härter G: Dtsch Arztebl Int. 2013 Feb;110(7):108
  54. First reported case of disease: Peliosis hepatis as cardinal symptom of Hodgkin's lymphoma. Kleger A, Bommer M, Kunze M, Klaus J, Leithaeuser F, Wegener M, Adler G, Dikopoulos N. Oncologist. 2009 Nov;14(11):1088-94.

  55.  

Buchkapitel

  1. Neue Therapieprinzipien: Zweitlinientherapie/Second Line, Targeted Therapies. Kleger A, Seufferlein T, Springer Verlag, „Erkrankungen des Pankreas“. Hans G. Beger et al.
  2. Intrapapilläre muzinöse Neoplasie Seufferlein T, Kleger A. Rationelle Diagnostik und Therapie in der Inneren Medizin, Elsevier.
  3. Duktales Pankreaskarzinom. Seufferlein T, Kleger A, Oettle H. Rationelle Diagnostik und Therapie in der Inneren Medizin, Elsevier.
  4. Gastrointestinale Onkologie, Thieme Verlag, Kleger, A: Kapitel Pankreaskarzinom 6.1 Epidemiologie, 6.2. Risikofaktoren und Risikogruppen sowie 6.3. Prävention, Screening, Surveillance. (Herausgeber: Helmut Messmann, Andrea Tannapfel, Jens Werner)

 

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Journal GUT, Volume 66, March 2017