Recent Publications

2024

  1. D’Acunto, E., Muzi, A., Marchese, S., Donnici, L., Chiarini, V., Bucci, F., Pavoni, E., Ferrara, F.F., Cappelletti, M., Arriga, R., Serrao, S.M., Peluzzi, V., Principato, E., Compagnone, M., Pinto, E., Luberto, L., Stoppoloni, D., Lahm, A., Groß, R., Seidel, A., Wettstein, L., Münch, J., Goodhead, A., Parisot, J., De Francesco, R., Ciliberto, G., Marra, E., Aurisicchio, L., Roscilli, G., 2024. Isolation and Characterization of Neutralizing Monoclonal Antibodies from a Large Panel of Murine Antibodies against RBD of the SARS-CoV-2 Spike Protein. Antibodies 13, 5. doi.org/10.3390/antib13010005
  2. Harms, M., Haase, A., Rodríguez-Alfonso, A., Löffler, J., Almeida-Hernández, Y., Ruiz-Blanco, Y.B., Albers, D., Gilg, A., von Bank, F., Zech, F., Groß, R., Datta, M., Jaikishan, J., Draphoen, B., Habib, M., Ständker, L., Wiese, S., Lindén, M., Winter, G., Rasche, V., Beer, A.J., Jumaa, H., Abadi, A.H., Kirchhoff, F., Busch, M., Dünker, N., Sanchez-Garcia, E., Münch, J., 2024. Fatty acid conjugated EPI-X4 derivatives with increased activity and in vivo stability. Journal of Controlled Release 373, 583–598. doi.org/10.1016/j.jconrel.2024.07.049
  3. Hayn, M., John, T., Bandak, J., Rauch-Wirth, L., Abel, B., Münch, J., 2024. Hybrid Materials From Peptide Nanofibrils and Magnetic Beads to Concentrate and Isolate Virus Particles. Advanced Functional Materials n/a, 2316260. doi.org/10.1002/adfm.202316260
  4. Hoenigsperger, H., Sivarajan, R., Sparrer, K.M., 2024. Differences and similarities between innate immune evasion strategies of human coronaviruses. Current Opinion in Microbiology 79, 102466. doi.org/10.1016/j.mib.2024.102466
  5. Klute, S., Sparrer, K.M.J., 2024. Friends and Foes: The Ambivalent Role of Autophagy in HIV-1 Infection. Viruses 16, 500. doi.org/10.3390/v16040500
  6. Prelli Bozzo, C., Laliberté, A., De Luna, A., Pastorio, C., Regensburger, K., Krebs, S., Graf, A., Blum, H., Volcic, M., Sparrer, K.M.J., Kirchhoff, F., 2024. Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef. Nat Commun 15, 3813. doi.org/10.1038/s41467-024-48228-x
  7. von Maltitz, P., Wettstein, L., Weil, T., Schommers, P., Klein, F., Münch, J., 2024. Semen enhances transmitted/founder HIV-1 infection and only marginally reduces antiviral activity of broadly neutralizing antibodies. Journal of Virology 0, e01190-23. doi.org/10.1128/jvi.01190-23
  8. Yin, K., Peluso, M.J., Luo, X., Thomas, R., Shin, M.-G., Neidleman, J., Andrew, A., Young, K.C., Ma, T., Hoh, R., Anglin, K., Huang, B., Argueta, U., Lopez, M., Valdivieso, D., Asare, K., Deveau, T.-M., Munter, S.E., Ibrahim, R., Ständker, L., Lu, S., Goldberg, S.A., Lee, S.A., Lynch, K.L., Kelly, J.D., Martin, J.N., Münch, J., Deeks, S.G., Henrich, T.J., Roan, N.R., 2024. Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2. Nat Immunol 25, 218–225. doi.org/10.1038/s41590-023-01724-6
  9. Zech, F., Jung, C., Jacob, T., Kirchhoff, F., 2024. Causes and Consequences of Coronavirus Spike Protein Variability. Viruses 16, 177. doi.org/10.3390/v16020177

2023

  1. Hoenigsperger H, Koepke L, Acharya D, Hunszinger V, Freisem D, Grenzner A, Wiese S, Kirchhoff F, Gack MU, Sparrer KMJ. 2023. CSNK2 suppresses autophagy by activating FLN-NHL-containing TRIM proteins. Autophagy 0:1–21.
  2. Hirschenberger M, Lepelley A, Rupp U, Klute S, Hunszinger V, Koepke L, Merold V, Didry-Barca B, Wondany F, Bergner T, Moreau T, Rodero MP, Rösler R, Wiese S, Volpi S, Gattorno M, Papa R, Lynch S-A, Haug MG, Houge G, Wigby KM, Sprague J, Lenberg J, Read C, Walther P, Michaelis J, Kirchhoff F, de Oliveira Mann CC, Crow YJ, Sparrer KMJ. 2023. ARF1 prevents aberrant type I interferon induction by regulating STING activation and recycling. 1. Nat Commun 14:6770.
  3. Schauenburg D, Zech F, Heck AJ, von Maltitz P, Harms M, Führer S, Alleva N, Münch J, Kuan SL, Kirchhoff F, Weil T. 2023. Peptide Bispecifics Inhibiting HIV-1 Infection by an Orthogonal Chemical and Supramolecular Strategy. Bioconjugate Chem 34:1645–1652.
  4. Gagiannis D, Hackenbroch C, Bloch W, Zech F, Kirchhoff F, Djudjaj S, Von Stillfried S, Bülow R, Boor P, Steinestel K. 2023. Clinical, Imaging, and Histopathological Features of Pulmonary Sequelae after Mild COVID-19. Am J Respir Crit Care Med 208:618–621.
  5. Engler M, Albers D, Maltitz PV, Groß R, Münch J, Cirstea IC. 2023. ACE2-EGFR-MAPK signaling contributes to SARS-CoV-2 infection. Life Science Alliance 6.
  6. Kaygisiz K, Rauch-Wirth L, Dutta A, Yu X, Nagata Y, Bereau T, Münch J, Synatschke CV, Weil T. 2023. Data-mining unveils structure–property–activity correlation of viral infectivity enhancing self-assembling peptides. 1. Nat Commun 14:5121.
  7. Geretz A, Ehrenberg PK, Clifford RJ, Laliberté A, Prelli Bozzo C, Eiser D, Kundu G, Yum LK, Apps R, Creegan M, Gunady M, Shangguan S, Sanders-Buell E, Sacdalan C, Phanuphak N, Tovanabutra S, Russell RM, Bibollet-Ruche F, Robb ML, Michael NL, Ake JA, Vasan S, Hsu DC, Hahn BH, Kirchhoff F, Thomas R. 2023. Single-cell transcriptomics identifies prothymosin α restriction of HIV-1 in vivo. Sci Transl Med 15:eadg0873.
  8. Millul J, Koepke L, Haridas GR, Sparrer KMJ, Mansi R, Fani M. 2023. Head-to-head comparison of different classes of FAP radioligands designed to increase tumor residence time: monomer, dimer, albumin binders, and small molecules vs peptides. Eur J Nucl Med Mol Imaging 50:3050–3061.
  9. Serman T, Chiang C, Liu G, Sayyad Z, Pandey S, Volcic M, Lee H, Muppala S, Acharya D, Goins C, Stauffer SR, Sparrer KMJ, Gack MU. 2023. Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication. Cell Host & Microbe 31:1317-1330.e10.
  10. Viox EG, Hoang TN, Upadhyay AA, Nchioua R, Hirschenberger M, Strongin Z, Tharp GK, Pino M, Nguyen K, Harper JL, Gagne M, Marciano S, Boddapati AK, Pellegrini KL, Pradhan A, Tisoncik-Go J, Whitmore LS, Karunakaran KA, Roy M, Kirejczyk S, Curran EH, Wallace C, Wood JS, Connor-Stroud F, Voigt EA, Monaco CM, Gordon DE, Kasturi SP, Levit RD, Gale M, Vanderford TH, Silvestri G, Busman-Sahay K, Estes JD, Vaccari M, Douek DC, Sparrer KMJ, Johnson RP, Kirchhoff F, Schreiber G, Bosinger SE, Paiardini M. 2023. Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques. Science Immunology 8:eadg0033.
  11. Heerde T, Schütz D, Lin Y-J, Münch J, Schmidt M, Fändrich M. 2023. Cryo-EM structure and polymorphic maturation of a viral transduction enhancing amyloid fibril. 1. Nat Commun 14:4293.
  12. Gaonkar RH, Schmidt YT, Mansi R, Almeida-Hernandez Y, Sanchez-Garcia E, Harms M, Münch J, Fani M. 2023. Development of a New Class of CXCR4-Targeting Radioligands Based on the Endogenous Antagonist EPI-X4 for Oncological Applications. J Med Chem 66:8484–8497.
  13. Marchitto L, Benlarbi M, Prévost J, Laumaea A, Descôteaux-Dinelle J, Medjahed H, Bourassa C, Gendron-Lepage G, Kirchhoff F, Sauter D, Hahn BH, Finzi A, Richard J. 2023. Impact of HIV-1 Vpu-mediated downregulation of CD48 on NK-cell-mediated antibody-dependent cellular cytotoxicity. mBio 14:e00789-23.
  14. Harms M, Smith N, Han M, Groß R, von Maltitz P, Stürzel C, Ruiz-Blanco YB, Almeida-Hernández Y, Rodriguez-Alfonso A, Cathelin D, Caspar B, Tahar B, Sayettat S, Bekaddour N, Vanshylla K, Kleipass F, Wiese S, Ständker L, Klein F, Lagane B, Boonen A, Schols D, Benichou S, Sanchez-Garcia E, Herbeuval J-P, Münch J. 2023. Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection. Science Advances 9:eadf8251.
  15. Kaygisiz K, Dutta A, Rauch-Wirth L, V. Synatschke C, Münch J, Bereau T, Weil T. 2023. Inverse design of viral infectivity-enhancing peptide fibrils from continuous protein-vector embeddings. Biomaterials Science 11:5251–5261.
  16. Pastorio C, Noettger S, Nchioua R, Zech F, Sparrer K, Kirchoff F. 2023. Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization. 4465491. SSRN Scholarly Paper. Rochester, NY doi.org/10.2139/ssrn.4465491.
  17. Nchioua R, Schundner A, Klute S, Koepke L, Hirschenberger M, Noettger S, Fois G, Zech F, Graf A, Krebs S, Braubach P, Blum H, Stenger S, Kmiec D, Frick M, Kirchhoff F, Sparrer KM. 2023. Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1. Life Science Alliance 6.
  18. Zech F, Weber S, Dietenberger H, Zhang L, Noettger S, Volcic M, Bergner T, Read C, Sparrer KMJ, Barth TFE, Kirchhoff F. 2023. SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor. 1. Sig Transduct Target Ther 8:1–4.
  19. Olari L-R, Bauer R, Gil Miró M, Vogel V, Cortez Rayas L, Groß R, Gilg A, Klevesath R, Rodríguez Alfonso AA, Kaygisiz K, Rupp U, Pant P, Mieres-Pérez J, Steppe L, Schäffer R, Rauch-Wirth L, Conzelmann C, Müller JA, Zech F, Gerbl F, Bleher J, Preising N, Ständker L, Wiese S, Thal DR, Haupt C, Jonker HRA, Wagner M, Sanchez-Garcia E, Weil T, Stenger S, Fändrich M, von Einem J, Read C, Walther P, Kirchhoff F, Spellerberg B, Münch J. 2023. The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties. Cell Mol Life Sci 80:151.
  20. Sparrer KMJ, Kirchhoff F. 2023. Cap snatch prevention: a novel approach to tackle influenza viruses. 1. Sig Transduct Target Ther 8:1–2.
  21. Seidel A, Hoffmann S, Jahrsdörfer B, Körper S, Ludwig C, Vieweg C, Albers D, von Maltitz P, Müller R, Lotfi R, Wuchter P, Klüter H, Kirchhoff F, Schmidt M, Münch J, Schrezenmeier H. 2023. SARS-CoV-2 vaccination of convalescents boosts neutralization capacity against Omicron subvariants BA.1, BA.2 and BA.5 and can be predicted by anti-S antibody concentrations in serological assays. Front Immunol 14:1170759.
  22. Seidel A, Jacobsen E-M, Fabricius D, Class M, Zernickel M, Blum C, Conzelmann C, Weil T, Groß R, Bode SFN, Renk H, Elling R, Stich M, Kirchhoff F, Debatin K-M, Münch J, Janda A. 2023. Serum neutralizing capacity and T-cell response against the omicron BA.1 variant in seropositive children and their parents one year after SARS-CoV-2 infection. Front Pediatr 11:1020865.
  23. Xie Q, Bozzo CP, Eiben L, Nöttger S, Kmiec D, Nchioua R, Niemeyer D, Volcic M, Lee J-H, Zech F, Sparrer KMJ, Drosten C, Kirchhoff F. 2023. Endogenous IFITMs boost SARS-Coronavirus 1 and 2 replication while overexpression inhibits infection by relocalizing ACE2. iScience 106395.
  24. Weil T, Münch J. 2023. Molekulare Pinzetten als Breitbandinhibitor viraler Infektionen. Biospektrum 29:150–152.
  25. Shahpasand-Kroner H, Siddique I, Malik R, Linares GR, Ivanova MI, Ichida J, Weil T, Münch J, Sanchez-Garcia E, Klärner F-G, Schrader T, Bitan G. 2023. Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications. Pharmacol Rev 75:263–308.
  26. Sparrer KMJ, Bergeron É, Gupta S. 2023. Editorial: Ubiquitin and ubiquitin-like modifications in viral infection and innate immunity. Frontiers in Immunology 14.
  27. Wettstein L, Immenschuh P, Weil T, Conzelmann C, Almeida-Hernández Y, Hoffmann M, Kempf A, Nehlmeier I, Lotke R, Petersen M, Stenger S, Kirchhoff F, Sauter D, Pöhlmann S, Sanchez-Garcia E, Münch J. 2023. Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection. Journal of Medical Virology 95:e28124.
  28. Rodriguez A, Martell-Huguet EM, González-García M, Alpízar-Pedraza D, Alba A, Vazquez AA, Grieshober M, Spellerberg B, Stenger S, Münch J, Kissmann A-K, Rosenau F, Wessjohann LA, Wiese S, Ständker L, Otero-Gonzalez AJ. 2023. Identification and Characterization of Three New Antimicrobial Peptides from the Marine Mollusk Nerita versicolor (Gmelin, 1791). 4. International Journal of Molecular Sciences 24:3852.
  29. Volcic M, Wiesmüller L, Kirchhoff F. 2023. Small but Highly Versatile: The Viral Accessory Protein Vpu. Annual Review of Virology 10:null.
  30. Groß R, Conzelmann C, Münch J, Müller JA. 2023. Detection of SARS-CoV-2 in Human Breast Milk, p. 129–135. In Aquino de Muro, M (ed.), Virus-Host Interactions: Methods and Protocols. Springer US, New York, NY.

2022

  1. Acharya D, Reis R, Volcic M, Liu G, Wang MK, Chia BS, Nchioua R, Groß R, Münch J, Kirchhoff F, Sparrer KMJ, Gack MU. 2022. Actin cytoskeleton remodeling primes RIG-I-like receptor activation. Cell 185:3588-3602.e21.
  2. Batista AD, Rajpal S, Keitel B, Dietl S, Fresco-Cala B, Dinc M, Groß R, Sobek H, Münch J, Mizaikoff B. 2022. Plastic Antibodies Mimicking the ACE2 Receptor for Selective Binding of SARS-CoV-2 Spike. Advanced Materials Interfaces 9:2101925.
  3. Bergner T, Zech F, Hirschenberger M, Stenger S, Sparrer KMJ, Kirchhoff F, Read C. 2022. Near-Native Visualization of SARS-CoV-2 Induced Membrane Remodeling and Virion Morphogenesis. 12. Viruses 14:2786.
  4. Conforti A, Marra E, Palombo F, Roscilli G, Ravà M, Fumagalli V, Muzi A, Maffei M, Luberto L, Lione L, Salvatori E, Compagnone M, Pinto E, Pavoni E, Bucci F, Vitagliano G, Stoppoloni D, Pacello ML, Cappelletti M, Ferrara FF, D’Acunto E, Chiarini V, Arriga R, Nyska A, Di Lucia P, Marotta D, Bono E, Giustini L, Sala E, Perucchini C, Paterson J, Ryan KA, Challis A-R, Matusali G, Colavita F, Caselli G, Criscuolo E, Clementi N, Mancini N, Groß R, Seidel A, Wettstein L, Münch J, Donnici L, Conti M, De Francesco R, Kuka M, Ciliberto G, Castilletti C, Capobianchi MR, Ippolito G, Guidotti LG, Rovati L, Iannacone M, Aurisicchio L. 2022. COVID-eVax, an electroporated DNA vaccine candidate encoding the SARS-CoV-2 RBD, elicits protective responses in animal models. Mol Ther 30:311–326.
  5. Conzelmann C, Muratspahić E, Tomašević N, Münch J, Gruber CW. 2022. In vitro Inhibition of HIV-1 by Cyclotide-Enriched Extracts of Viola tricolor. Front Pharmacol 13:888961.
  6. Conzelmann C, Weil T, Olari L-R, Gilg A, Rauch L, Albers DPJ, Groß R, Müller JA, Münch J. 2022. Virucidal activity of SARS-CoV-2 rapid antigen extraction buffers. Journal of Clinical Virology 147:105062.
  7. Fittje P, Hœlzemer A, Garcia-Beltran WF, Vollmers S, Niehrs A, Hagemann K, Martrus G, Körner C, Kirchhoff F, Sauter D, Altfeld M. 2022. HIV-1 Nef-mediated downregulation of CD155 results in viral restriction by KIR2DL5+ NK cells. PLOS Pathogens 18:e1010572.
  8. Gerstenberg M, Stürzel CM, Weil T, Kirchhoff F, Lindén M. 2021. Modular Hydrogel−Mesoporous Silica Nanoparticle Constructs for Therapy and Diagnostics. Advanced NanoBiomed Research n/a:2100125.
  9. Groß R, Conzelmann C, Münch J, Müller JA. 2023. Detection of SARS-CoV-2 in Human Breast Milk, p. 129–135. In Aquino de Muro, M (ed.), Virus-Host Interactions: Methods and Protocols. Springer US, New York, NY.
  10. Groß R, Dias Loiola LM, Issmail L, Uhlig N, Eberlein V, Conzelmann C, Olari L-R, Rauch L, Lawrenz J, Weil T, Müller JA, Cardoso MB, Gilg A, Larsson O, Höglund U, Pålsson SA, Tvilum AS, Løvschall KB, Kristensen MM, Spetz A-L, Hontonnou F, Galloux M, Grunwald T, Zelikin AN, Münch J. 2022. Macromolecular Viral Entry Inhibitors as Broad-Spectrum First-Line Antivirals with Activity against SARS-CoV-2. Advanced Science n/a:2201378.
  11. Groß R, Kleger A. 2022. COVID-19 and diabetes — where are we now? 12. Nat Metab 4:1611–1613.
  12. Groß R, Zanoni M, Seidel A, Conzelmann C, Gilg A, Krnavek D, Erdemci-Evin S, Mayer B, Hoffmann M, Pöhlmann S, Liu W, Hahn BH, Beil A, Kroschel J, Jahrsdörfer B, Schrezenmeier H, Kirchhoff F, Münch J, Müller JA. 2021. Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants. EBioMedicine 75:103761.
  13. Harms M, Hansson RF, Carmali S, Almeida-Hernández Y, Sanchez-Garcia E, Münch J, Zelikin AN. 2022. Dimerization of the Peptide CXCR4-Antagonist on Macromolecular and Supramolecular Protraction Arms Affords Increased Potency and Enhanced Plasma Stability. Bioconjug Chem 33:594–607.
  14. Harms M, Hayn M, Zech F, Kirchhoff F, Münch J. 2022. Endogenous Peptide Inhibitors of HIV Entry. Adv Exp Med Biol 1366:65–85.
  15. Harms M, von Maltitz P, Groß R, Mayer B, Deniz M, Müller J, Münch J. 2022. Utilization of Aminoguanidine Prevents Cytotoxic Effects of Semen. Int J Mol Sci 23:8563.
  16. Jacobsen E-M, Fabricius D, Class M, Topfstedt F, Lorenzetti R, Janowska I, Schmidt F, Staniek J, Zernickel M, Stamminger T, Dietz AN, Zellmer A, Hecht M, Rauch P, Blum C, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Heeg M, Mayer B, Seidel A, Groß R, Münch J, Kirchhoff F, Bode SFN, Strauss G, Renk H, Elling R, Stich M, Voll RE, Tönshof B, Franz AR, Henneke P, Debatin K-M, Rizzi M, Janda A. 2022. High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection. 1. Nat Commun 13:7315.
  17. Jung C, Kmiec D, Koepke L, Zech F, Jacob T, Sparrer KMJ, Kirchhoff F. 2022. Omicron: what makes the latest SARS-CoV-2 variant of concern so concerning? J Virol jvi0207721.
  18. Klute S, Hoenigsperger H, Sparrer KMJ. 2022. Unexpected little helpers: microbiota stimulate systemic antiviral defenses. 1. Sig Transduct Target Ther 7:1–2.
  19. Kmiec D, Kirchhoff F. 2022. Monkeypox: A New Threat? 14. International Journal of Molecular Sciences 23:7866.
  20. Knaff PM, Müller P, Kersten C, Wettstein L, Münch J, Landfester K, Mailänder V. 2022. Structure-Based Design of High-Affinity and Selective Peptidomimetic Hepsin Inhibitors. Biomacromolecules 23:2236–2242.
  21. Lawrenz J, Xie Q, Zech F, Weil T, Seidel A, Krnavek D, van der Hoek L, Münch J, Müller JA, Kirchhoff F. 2022. SARS-CoV-2 Vaccination boosts Neutralizing Activity against Seasonal Human Coronaviruses. Clinical Infectious Diseases ciac057.
  22. Lee J-H, Koepke L, Kirchhoff F, Sparrer KMJ. 2022. Interferon antagonists encoded by SARS-CoV-2 at a glance. Med Microbiol Immunol doi.org/10.1007/s00430-022-00734-9.
  23. Mezger MC, Conzelmann C, Weil T, von Maltitz P, Albers DPJ, Münch J, Stamminger T, Schilling E-M. 2022. Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression. Viruses 14:1308.
  24. Nchioua R, Diofano F, Noettger S, von Maltitz P, Stenger S, Zech F, Münch J, Sparrer KMJ, Just S, Kirchhoff F. 2022. Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes. 1. Sig Transduct Target Ther 7:1–3.
  25. Nchioua R, Schundner A, Kmiec D, Prelli Bozzo C, Zech F, Koepke L, Graf A, Krebs S, Blum H, Frick M, Sparrer KMJ, Kirchhoff F. 2022. SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells. J Virol e0059422.
  26. Pastorio C, Zech F, Noettger S, Jung C, Jacob T, Sanderson T, Sparrer KMJ, Kirchhoff F. 2022. Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2. Cell Host & Microbe doi.org/10.1016/j.chom.2022.07.006.
  27. Prelli Bozzo C, Kmiec D, Kirchhoff F. 2022. When good turns bad: how viruses exploit innate immunity factors. Current Opinion in Virology 52:60–67.
  28. Prévost J, Anand SP, Rajashekar JK, Zhu L, Richard J, Goyette G, Medjahed H, Gendron-Lepage G, Chen H-C, Chen Y, Horwitz JA, Grunst MW, Zolla-Pazner S, Haynes BF, Burton DR, Flavell RA, Kirchhoff F, Hahn BH, Smith AB, Pazgier M, Nussenzweig MC, Kumar P, Finzi A. 2022. HIV-1 Vpu restricts Fc-mediated effector functions in vivo. Cell Reports 41:111624.
  29. Prévost J, Richard J, Gasser R, Medjahed H, Kirchhoff F, Hahn BH, Kappes JC, Ochsenbauer C, Duerr R, Finzi A. 2022. Detection of the HIV-1 accessory proteins Nef and Vpu by flow cytometry represents a new tool to study their functional interplay within a single infected CD4+ T cell. J Virol jvi0192921.
  30. Renk H, Dulovic A, Seidel A, Becker M, Fabricius D, Zernickel M, Junker D, Groß R, Müller J, Hilger A, Bode SFN, Fritsch L, Frieh P, Haddad A, Görne T, Remppis J, Ganzemueller T, Dietz A, Huzly D, Hengel H, Kaier K, Weber S, Jacobsen E-M, Kaiser PD, Traenkle B, Rothbauer U, Stich M, Tönshoff B, Hoffmann GF, Müller B, Ludwig C, Jahrsdörfer B, Schrezenmeier H, Peter A, Hörber S, Iftner T, Münch J, Stamminger T, Groß H-J, Wolkewitz M, Engel C, Liu W, Rizzi M, Hahn BH, Henneke P, Franz AR, Debatin K-M, Schneiderhan-Marra N, Janda A, Elling R. 2022. Robust and durable serological response following pediatric SARS-CoV-2 infection. 1. Nat Commun 13:128.
  31. Rodríguez-Alfonso A, Heck A, Ruiz-Blanco YB, Gilg A, Ständker L, Kuan SL, Weil T, Sanchez-Garcia E, Wiese S, Münch J, Harms M. 2022. Advanced EPI-X4 Derivatives Covalently Bind Human Serum Albumin Resulting in Prolonged Plasma Stability. 23. International Journal of Molecular Sciences 23:15029.
  32. Romero-Molina S, Ruiz-Blanco YB, Mieres-Perez J, Harms M, Münch J, Ehrmann M, Sanchez-Garcia E. 2022. PPI-Affinity: A Web Tool for the Prediction and Optimization of Protein-Peptide and Protein-Protein Binding Affinity. J Proteome Res doi.org/10.1021/acs.jproteome.2c00020.
  33. Ruiz-Blanco YB, Agüero-Chapin G, Romero-Molina S, Antunes A, Olari L-R, Spellerberg B, Münch J, Sanchez-Garcia E. 2022. ABP-Finder: A Tool to Identify Antibacterial Peptides and the Gram-Staining Type of Targeted Bacteria. 12. Antibiotics 11:1708.
  34. Schmidt H, Gutjahr L, Sauter A, Zech F, Nchioua R, Stenger S, Frick M, Kirchhoff F, Dietl P, Wittekindt OH. 2022. Serially passaged, conditionally reprogrammed nasal epithelial cells as a model to study epithelial functions and SARS-CoV-2 infection. American Journal of Physiology-Cell Physiology doi.org/10.1152/ajpcell.00363.2021.
  35. Schorer V, Haas J, Stach R, Kokoric V, Groß R, Muench J, Hummel T, Sobek H, Mennig J, Mizaikoff B. 2022. Towards the direct detection of viral materials at the surface of protective face masks via infrared spectroscopy. 1. Sci Rep 12:2309.
  36. Seidel A, Zanoni M, Groß R, Krnavek D, Erdemci-Evin S, von Maltitz P, Albers DPJ, Conzelmann C, Liu S, Weil T, Mayer B, Hoffmann M, Pöhlmann S, Beil A, Kroschel J, Kirchhoff F, Münch J, Müller JA. 2022. BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults. Front Immunol 13:882918.
  37. Shahpasand-Kroner H, Siddique I, Malik R, Linares G, Ivanova MI, Ichida J, Weil T, Münch J, Sanchez-Garcia E, Klärner F-G, Schrader T, Bitan G. 2022. Molecular tweezers - supramolecular hosts with broad-spectrum biological applications. Pharmacol Rev doi.org/10.1124/pharmrev.122.000654.
  38. Sollmann N, Beer AJ, Kirchhoff F. 2022. SARS-CoV-2 infection and the brain: direct evidence for brain changes in milder cases. 1. Sig Transduct Target Ther 7:1–3.
  39. Truong TT, Hayn M, Frich CK, Olari L-R, Ladefoged LK, Olesen MTJ, Jakobsen JH, Lunabjerg-Vestergaard CK, Schiøtt B, Münch J, Zelikin AN. 2022. Potentiation of Drug Toxicity through Virus Latency Reversal Promotes Preferential Elimination of HIV Infected Cells. Advanced Therapeutics 5:2200113.
  40. Vogel V, Fuchs M, Jachmann M, Bitzer A, Mauerer S, Münch J, Spellerberg B. 2022. The Role of SilX in Bacteriocin Production of Streptococcus anginosus. Frontiers in Microbiology 13.
  41. Vogel V, Olari L-R, Jachmann M, Reich SJ, Häring M, Kissmann A-K, Rosenau F, Riedel CU, Münch J, Spellerberg B. 2022. The bacteriocin Angicin interferes with bacterial membrane integrity through interaction with the mannose phosphotransferase system. Frontiers in Microbiology 13.
  42. Weil T, Kirupakaran A, Le M-H, Rebmann P, Mieres-Perez J, Issmail L, Conzelmann C, Müller JA, Rauch L, Gilg A, Wettstein L, Groß R, Read C, Bergner T, Pålsson SA, Uhlig N, Eberlein V, Wöll H, Klärner F-G, Stenger S, Kümmerer BM, Streeck H, Fois G, Frick M, Braubach P, Spetz A-L, Grunwald T, Shorter J, Sanchez-Garcia E, Schrader T, Münch J. 2022. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2:2187–2202.
  43. Weil T, Lawrenz J, Seidel A, Münch J, Müller JA. 2022. Immunodetection assays for the quantification of seasonal common cold coronaviruses OC43, NL63, or 229E infection confirm nirmatrelvir as broad coronavirus inhibitor. Antiviral Res 203:105343.
  44. Wettstein L, Immenschuh P, Weil T, Conzelmann C, Almeida-Hernández Y, Hoffmann M, Kempf A, Nehlmeier I, Lotke R, Petersen M, Stenger S, Kirchhoff F, Sauter D, Pöhlmann S, Sanchez-Garcia E, Münch J. 2023. Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection. Journal of Medical Virology 95:e28124.
  45. Wettstein L, Kirchhoff F, Münch J. 2022. The Transmembrane Protease TMPRSS2 as a Therapeutic Target for COVID-19 Treatment. 3. International Journal of Molecular Sciences 23:1351.
  46. Wettstein L, Knaff PM, Kersten C, Müller P, Weil T, Conzelmann C, Müller JA, Brückner M, Hoffmann M, Pöhlmann S, Schirmeister T, Landfester K, Münch J, Mailänder V. 2022. Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture. Commun Biol 5:681.

2021

  1. Arnold F, Gout J, Wiese H, Weissinger SE, Roger E, Perkhofer L, Walter K, Scheible J, Bozzo CP, Lechel A, Ettrich TJ, Azoitei N, Hao L, Fürstberger A, Kaminska EK, Sparrer KMJ, Rasche V, Wiese S, Kestler HA, Möller P, Seufferlein T, Frappart P-O, Kleger A. 2021. RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer. Cancer Res 81:1758–1774.
  2. Bosso M, Stürzel CM, Kmiec D, Badarinarayan SS, Braun E, Ito J, Sato K, Hahn BH, Sparrer KMJ, Sauter D, Kirchhoff F. 2021. An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins. Cell Reports 36:109735.
  3. Brenner S, Braun B, Read C, Weil T, Walther P, Schrader T, Münch J, von Einem J. 2021. The Molecular Tweezer CLR01 Inhibits Antibody-Resistant Cell-to-Cell Spread of Human Cytomegalovirus. 9. Viruses 13:1685.
  4. Castro-Gonzalez S, Shi Y, Colomer-Lluch M, Song Y, Mowery K, Almodovar S, Bansal A, Kirchhoff F, Sparrer K, Liang C, Serra-Moreno R. 2020. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Autophagy 1–25.
  5. Conzelmann C, Groß R, Meister TL, Todt D, Krawczyk A, Dittmer U, Stenger S, Münch J, Steinmann E, Müller JA, Pfaender S. 2021. Pasteurization Inactivates SARS-CoV-2-Spiked Breast Milk. Pediatrics 147.
  6. Cui W, Braun E, Wang W, Tang J, Zheng Y, Slater B, Li N, Chen C, Liu Q, Wang B, Li X, Duan Y, Xiao Y, Ti R, Hotter D, Ji X, Zhang L, Cui J, Xiong Y, Sauter D, Wang Z, Kirchhoff F, Yang H. 2021. Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. PNAS 118.
  7. Eberle J, Wiehe RS, Gole B, Mattis LJ, Palmer A, Ständker L, Forssmann W-G, Münch J, Gebhardt JCM, Wiesmüller L. 2021. A Fibrinogen Alpha Fragment Mitigates Chemotherapy-Induced MLL Rearrangements. Front Oncol 11.
  8. Enderle AG, Bosso M, Groß R, Heiland M, Bollini M, Culzoni MJ, Münch J, Streb C. 2021. Increased in-vitro Anti-HIV Activity of Caffeinium-functionalized Polyoxometalates. ChemMedChem doi.org/10.1002/cmdc.202100281.
  9. Gilg A, Harms M, Olari L-R, Urbanowitz A-K, Bonig H, Münch J. 2021. Absence of the CXCR4 antagonist EPI-X4 from pharmaceutical human serum albumin preparations. Journal of Translational Medicine 19:190.
  10. González-García M, Morales-Vicente F, Pico ED, Garay H, Rivera DG, Grieshober M, Raluca Olari L, Groß R, Conzelmann C, Krüger F, Zech F, Prelli Bozzo C, Müller JA, Zelikin A, Raber H, Kubiczek D, Rosenau F, Münch J, Stenger S, Spellerberg B, Franco OL, Rodriguez Alfonso AA, Ständker L, Otero-Gonzalez AJ. 2021. Antimicrobial Activity of Cyclic-Monomeric and Dimeric Derivatives of the Snail-Derived Peptide Cm-p5 against Viral and Multidrug-Resistant Bacterial Strains. 5. Biomolecules 11:745.
  11. Groß R, Zanoni M, Seidel A, Conzelmann C, Gilg A, Krnavek D, Erdemci-Evin S, Mayer B, Hoffmann M, Pöhlmann S, Liu W, Hahn BH, Beil A, Kroschel J, Jahrsdörfer B, Schrezenmeier H, Kirchhoff F, Münch J, Müller JA. 2021. Heterologous ChAdOx1 nCoV-19 and BNT162b2 prime-boost vaccination elicits potent neutralizing antibody responses and T cell reactivity against prevalent SARS-CoV-2 variants. EBioMedicine 75:103761.
  12. Haehnle B, Lamla M, Sparrer KMJ, Gather MC, Kuehne AJC. 2020. Narrow Stimulated Resonance Raman Scattering and WGM Lasing in Small Conjugated Polymer Particles for Live Cell Tagging and Tracking. Advanced Optical Materials n/a:2001553.
  13. Harms M, Habib MMW, Nemska S, Nicolò A, Gilg A, Preising N, Sokkar P, Carmignani S, Raasholm M, Weidinger G, Kizilsavas G, Wagner M, Ständker L, Abadi AH, Jumaa H, Kirchhoff F, Frossard N, Sanchez-Garcia E, Münch J. 2020. An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation. Acta Pharmaceutica Sinica B doi.org/10.1016/j.apsb.2020.12.005.
  14. Hayn M, Blötz A, Rodríguez A, Vidal S, Preising N, Ständker L, Wiese S, Stürzel CM, Harms M, Gross R, Jung C, Kiene M, Jacob T, Pöhlmann S, Forssmann W-G, Münch J, Sparrer KMJ, Seuwen K, Hahn BH, Kirchhoff F. 2021. Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling. PNAS 118.
  15. Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Bozzo CP, Aftab W, Christensen MH, Conzelmann C, Müller JA, Badarinarayan SS, Stürzel CM, Forne I, Stenger S, Conzelmann K-K, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Johannes Sparrer KM. 2021. Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities. Cell Reports 109126.
  16. Hirschenberger M, Hayn M, Laliberté A, Koepke L, Kirchhoff F, Sparrer KMJ. 2021. Luciferase reporter assays to monitor interferon signaling modulation by SARS-CoV-2 proteins. STAR Protocols 2:100781.
  17. Hirschenberger M, Stadler N, Fellermann M, Sparrer KMJ, Kirchhoff F, Barth H, Papatheodorou P. 2021. CRISPA: A Non-viral, Transient Cas9 Delivery System Based on Reengineered Anthrax Toxin. Frontiers in Pharmacology 12:2861.
  18. Hoffmann M, Arora P, Groß R, Seidel A, Hörnich BF, Hahn AS, Krüger N, Graichen L, Hofmann-Winkler H, Kempf A, Winkler MS, Schulz S, Jäck H-M, Jahrsdörfer B, Schrezenmeier H, Müller M, Kleger A, Münch J, Pöhlmann S. 2021. SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies. Cell doi.org/10.1016/j.cell.2021.03.036.
  19. Huot N, Rascle P, Petitdemange C, Contreras V, Stürzel CM, Baquero E, Harper JL, Passaes C, Legendre R, Varet H, Madec Y, Sauermann U, Stahl-Hennig C, Nattermann J, Saez-Cirion A, Le Grand R, Keith Reeves R, Paiardini M, Kirchhoff F, Jacquelin B, Müller-Trutwin M. 2021. SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity. Nat Commun 12:1282.
  20. Kaiser LM, Harms M, Sauter D, Rawat VPS, Glitscher M, Hildt E, Tews D, Hunter Z, Münch J, Buske C. 2021. Targeting of CXCR4 by the Naturally Occurring CXCR4 Antagonist EPI-X4 in Waldenström’s Macroglobulinemia. 4. Cancers 13:826.
  21. Kimura I, Konno Y, Uriu K, Hopfensperger K, Sauter D, Nakagawa S, Sato K. 2021. Sarbecovirus ORF6 proteins hamper induction of interferon signaling. Cell Reports 34:108916.
  22. Koepke L, Gack MU, Sparrer KM. 2021. The antiviral activities of TRIM proteins. Current Opinion in Microbiology 59:50–57.
  23. Krüger J, Groß R, Conzelmann C, Müller JA, Koepke L, Sparrer KMJ, Weil T, Schütz D, Seufferlein T, Barth TFE, Stenger S, Heller S, Münch J, Kleger A. 2021. Drug Inhibition of SARS-CoV-2 Replication in Human Pluripotent Stem Cell–Derived Intestinal Organoids. Cellular and Molecular Gastroenterology and Hepatology 11:935–948.
  24. McGuire MK, Seppo A, Goga A, Buonsenso D, Collado MC, Donovan SM, Müller JA, Ofman G, Monroy-Valle M, O’Connor DL, Pace RM, Van de Perre P. 2021. Best Practices for Human Milk Collection for COVID-19 Research. Breastfeed Med 16:29–38.
  25. Mohapatra S, Viswanathan GKK, Wettstein L, Arad E, Paul A, Kumar V, Jelinek R, Münch J, Segal D. 2021. Dual concentration-dependent effect of ascorbic acid on PAP(248–286) amyloid formation and SEVI-mediated HIV infection. RSC Chem Biol doi.org/10.1039/D1CB00084E.
  26. Müller JA, Groß R, Conzelmann C, Krüger J, Merle U, Steinhart J, Weil T, Koepke L, Bozzo CP, Read C, Fois G, Eiseler T, Gehrmann J, van Vuuren J, Wessbecher IM, Frick M, Costa IG, Breunig M, Grüner B, Peters L, Schuster M, Liebau S, Seufferlein T, Stenger S, Stenzinger A, MacDonald PE, Kirchhoff F, Sparrer KMJ, Walther P, Lickert H, Barth TFE, Wagner M, Münch J, Heller S, Kleger A. 2021. SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas. Nature Metabolism 1–17.
  27. Nchioua R, Kmiec D, Gaba A, Stürzel CM, Follack T, Patrick S, Kirmaier A, Johnson WE, Hahn BH, Chelico L, Kirchhoff F. 2021. APOBEC3F constitutes a barrier to successful cross-species transmission of SIVsmm to humans. J Virol JVI0080821.
  28. Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel CM, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Alfonso AAR, Wiese S, Sauter D, Münch J, Goffinet C, Catanese A, Schön M, Boeckers TM, Stenger S, Sato K, Just S, Kleger A, Sparrer KMJ, Kirchhoff F. 2021. IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro. 1. Nat Commun 12:1–13.
  29. Sauter D, Kirchhoff F. 2021. Evolutionary conflicts and adverse effects of antiviral factors. eLife 10:e65243.
  30. Sauter D, Kirchhoff F. 2021. Less is more: Biased loss of CpG dinucleotides strengthens antiviral immunity. PLoS Biol 19:e3001353.
  31. Schütz D, Conzelmann C, Fois G, Groß R, Weil T, Wettstein L, Stenger S, Zelikin A, Hoffmann TK, Frick M, Müller JA, Münch J. 2021. Carrageenan containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures. American Journal of Physiology-Lung Cellular and Molecular Physiology doi.org/10.1152/ajplung.00552.2020.
  32. Schütz D, Read C, Groß R, Röcker A, Rode S, Annamalai K, Fändrich M, Münch J. 2021. Negatively Charged Peptide Nanofibrils from Immunoglobulin Light Chain Sequester Viral Particles but Lack Cell-Binding and Viral Transduction-Enhancing Properties. ACS Omega 6:7731–7738.
  33. Schütz D, Rode S, Read C, Müller JA, Glocker B, Sparrer KMJ, Fackler OT, Walther P, Münch J. 2021. Viral Transduction Enhancing Effect of EF-C Peptide Nanofibrils Is Mediated by Cellular Protrusions. Advanced Functional Materials n/a:2104814.
  34. Sieste S, Mack T, Lump E, Hayn M, Schütz D, Röcker A, Meier C, Kaygisiz K, Kirchhoff F, Knowles TPJ, Ruggeri FS, Synatschke CV, Münch J, Weil T. 2021. Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction. Advanced Functional Materials 31:2009382.
  35. Sokkar P, Harms M, Stürzel C, Gilg A, Kizilsavas G, Raasholm M, Preising N, Wagner M, Kirchhoff F, Ständker L, Weidinger G, Mayer B, Münch J, Sanchez-Garcia E. 2021. Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists. Commun Biol 4:1–13.
  36. Sparrer KMJ, Kirchhoff F. 2021. HIV protease: late action to prevent immune detection. Signal Transduct Target Ther 6:157.
  37. Spatz DL, Davanzo R, Müller JA, Powell R, Rigourd V, Yates A, Geddes DT, van Goudoever JB, Bode L. 2021. Promoting and Protecting Human Milk and Breastfeeding in a COVID-19 World. Front Pediatr 8.
  38. Tripathi U, Nchioua R, Prata LGPL, Zhu Y, Gerdes EOW, Giorgadze N, Pirtskhalava T, Parker E, Xue A, Espindola-Netto JM, Stenger S, Robbins PD, Niedernhofer LJ, Dickinson SL, Allison DB, Kirchhoff F, Sparrer KMJ, Tchkonia T, Kirkland JL. 2021. SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3. Aging (Albany NY) 13:21838–21854.
  39. Vanshylla K, Held K, Eser TM, Gruell H, Kleipass F, Stumpf R, Jain K, Weiland D, Münch J, Grüttner B, Geldmacher C, Klein F. 2021. CD34T+ Humanized Mouse Model to Study Mucosal HIV-1 Transmission and Prevention. Vaccines (Basel) 9.
  40. Wettstein L, Weil T, Conzelmann C, Müller JA, Groß R, Hirschenberger M, Seidel A, Klute S, Zech F, Prelli Bozzo C, Preising N, Fois G, Lochbaum R, Knaff PM, Mailänder V, Ständker L, Thal DR, Schumann C, Stenger S, Kleger A, Lochnit G, Mayer B, Ruiz-Blanco YB, Hoffmann M, Sparrer KMJ, Pöhlmann S, Sanchez-Garcia E, Kirchhoff F, Frick M, Münch J. 2021. Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection. 1. Nature Communications 12:1726.
  41. Wieland J, Frey S, Rupp U, Essbauer S, Groß R, Münch J, Walther P. 2021. Zika virus replication in glioblastoma cells: electron microscopic tomography shows 3D arrangement of endoplasmic reticulum, replication organelles, and viral ribonucleoproteins. Histochem Cell Biol doi.org/10.1007/s00418-021-02028-2.
  42. Xia S, Lan Q, Zhu Y, Wang C, Xu W, Li Y, Wang L, Jiao F, Zhou J, Hua C, Wang Q, Cai X, Wu Y, Gao J, Liu H, Sun G, Münch J, Kirchhoff F, Yuan Z, Xie Y, Sun F, Jiang S, Lu L. 2021. Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation. Sig Transduct Target Ther 6:1–10.
  43. Zech F, Schniertshauer D, Jung C, Herrmann A, Cordsmeier A, Xie Q, Nchioua R, Prelli Bozzo C, Volcic M, Koepke L, Müller JA, Krüger J, Heller S, Stenger S, Hoffmann M, Pöhlmann S, Kleger A, Jacob T, Conzelmann K-K, Ensser A, Sparrer KMJ, Kirchhoff F. 2021. Spike residue 403 affects binding of coronavirus spikes to human ACE2. Nat Commun 12:6855.

2020

  1. Bosso M, Kirchhoff F. 2020. Emerging Role of PYHIN Proteins as Antiviral Restriction Factors. 12. Viruses 12:1464.
  2. Bosso M, Prelli-Bozzo C, Hotter D, Volcic M, Stürzel CM, Rammelt A, Ni Y, Urban S, Becker M, Schelhaas M, Wittmann S, Christensen MH, Schmidt FI, Gramberg T, Sparrer KMJ, Sauter D, Kirchhoff F. 2020. Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells. PLoS Pathogens 16:e1008752.
  3. Braun K, Stürzel C, Kirchhoff F, Lindén M. 2020. In Vitro Evaluation of a Peptide-Mesoporous Silica Nanoparticle Drug Release System against HIV-1. Inorganics 8:42.
  4. Castro-Gonzalez S, Shi Y, Colomer-Lluch M, Song Y, Mowery K, Almodovar S, Bansal A, Kirchhoff F, Sparrer K, Liang C, Serra-Moreno R. 2020. HIV-1 Nef counteracts autophagy restriction by enhancing the association between BECN1 and its inhibitor BCL2 in a PRKN-dependent manner. Autophagy 1–25.
  5. Conzelmann C, Gilg A, Groß R, Schütz D, Preising N, Ständker L, Jahrsdörfer B, Schrezenmeier H, Sparrer KMJ, Stamminger T, Stenger S, Münch J, Müller JA. 2020. An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection. Antiviral Research 181:104882.
  6. Conzelmann C, Groß R, Zou M, Krüger F, Görgens A, Gustafsson MO, El Andaloussi S, Münch J, Müller JA. 2020. Salivary extracellular vesicles inhibit Zika virus but not SARS-CoV-2 infection. Journal of Extracellular Vesicles 9:1808281.
  7. Conzelmann C, Müller JA, Perkhofer L, Sparrer KM, Zelikin AN, Münch J, Kleger A. 2020. Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19. Clinical Medicine 20:clinmed.2020-0351.
  8. Groß R, Bauer R, Krüger F, Rücker-Braun E, Olari LR, Ständker L, Preising N, Rodríguez AA, Conzelmann C, Gerbl F, Sauter D, Kirchhoff F, Hagemann B, Gačanin J, Weil T, Ruiz-Blanco YB, Sanchez-Garcia E, Forssmann WG, Mankertz A, Santibanez S, Stenger S, Walther P, Wiese S, Spellerberg B, Münch J. 2020. A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity. Frontiers in Microbiology 11:508.
  9. Groß R, Conzelmann C, Müller JA, Stenger S, Steinhart K, Kirchhoff F, Münch J. 2020. Detection of SARS-CoV-2 in human breastmilk. The Lancet 395:1757–1758.
  10. Groß R, Conzelmann C, Müller JA, Reister F, Kirchhoff F, Münch J. 2020. Undermining breastfeeding will not alleviate the COVID-19 pandemic – Authors’ reply. The Lancet 396:1065–1066.
  11. Haehnle B, Lamla M, Sparrer KMJ, Gather MC, Kuehne AJC. 2020. Narrow Stimulated Resonance Raman Scattering and WGM Lasing in Small Conjugated Polymer Particles for Live Cell Tagging and Tracking. Advanced Optical Materials n/a:2001553.
  12. Haeseleer F, Eichholz K, Tareen SU, Iwamoto N, Roederer M, Kirchhoff F, Park H, Okoye AA, Corey L. 2020. Real-Time Killing Assays to Assess the Potency of a New Anti-Simian Immunodeficiency Virus Chimeric Antigen Receptor T Cell. AIDS Research and Human Retroviruses 36:998–1009.
  13. Harms M, Gilg A, Ständker L, Beer AJ, Mayer B, Rasche V, Gruber CW, Münch J. 2020. Microtiter plate-based antibody-competition assay to determine binding affinities and plasma/blood stability of CXCR4 ligands. Scientific Reports 10:16036.
  14. Harms M, Habib MMW, Nemska S, Nicolò A, Gilg A, Preising N, Sokkar P, Carmignani S, Raasholm M, Weidinger G, Kizilsavas G, Wagner M, Ständker L, Abadi AH, Jumaa H, Kirchhoff F, Frossard N, Sanchez-Garcia E, Münch J. 2020. An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation. Acta Pharmaceutica Sinica B doi.org/10.1016/j.apsb.2020.12.005.
  15. Holch A, Bauer R, Olari L-R, Rodriguez AA, Ständker L, Preising N, Karacan M, Wiese S, Walther P, Ruiz-Blanco YB, Sanchez-Garcia E, Schumann C, Münch J, Spellerberg B. 2020. Respiratory ß-2-Microglobulin exerts pH dependent antimicrobial activity. Virulence 11:1402–1414.
  16. Hopfensperger K, Richard J, Stürzel CM, Bibollet-Ruche F, Apps R, Leoz M, Plantier J-C, Hahn BH, Finzi A, Kirchhoff F, Sauter D. 2020. Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2. mBio 11.
  17. Hopfensperger K, Sautera D. 2020. Decreased, deformed, defective-how HIV-1 vpu targets peroxisomes. mBio 11.
  18. Joas S, Sauermann U, Roshani B, Klippert A, Daskalaki M, Mätz-Rensing K, Stolte-Leeb N, Heigele A, Tharp GK, Gupta PM, Nelson S, Bosinger S, Parodi L, Giavedoni L, Silvestri G, Sauter D, Stahl-Hennig C, Kirchhoff F. 2020. Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion. Cell Reports 30:2261-2274.e7.
  19. Kmiec D, Nchioua R, Sherrill-Mix S, Stürzel CM, Heusinger E, Braun E, Gondim MVP, Hotter D, Sparrer KMJ, Hahn BH, Sauter D, Kirchhoff F. 2020. CpG frequency in the 5’ third of the env gene determines sensitivity of primary HIV-1 strains to the zinc-finger antiviral protein. mBio 11.
  20. Koepke L, Winter B, Grenzner A, Regensburger K, Engelhart S, van der Merwe JA, Krebs S, Blum H, Kirchhoff F, Sparrer KMJ. 2020. An improved method for high-throughput quantification of autophagy in mammalian cells. Scientific Reports 10.
  21. Konno Y, Kimura I, Uriu K, Fukushi M, Irie T, Koyanagi Y, Sauter D, Gifford RJ, Nakagawa S, Sato K. 2020. SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant. Cell Reports 32:108185.
  22. Meister TL, Brüggemann Y, Todt D, Conzelmann C, Müller JA, Groß R, Münch J, Krawczyk A, Steinmann J, Steinmann J, Pfaender S, Steinmann E. 2020. Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2. The Journal of infectious diseases 222:1289–1292.
  23. Mesner D, Hotter D, Kirchhoff F, Jolly C. 2020. Loss of Nef-mediated CD3 down-regulation in the HIV-1 lineage increases viral infectivity and spread. Proceedings of the National Academy of Sciences of the United States of America 117:7382–7391.
  24. Michel D, Danzer KM, Groß R, Conzelmann C, Müller JA, Freischmidt A, Weishaupt JH, Heller S, Münch J, Michel M, Stamminger T, Kleger A, Otto M. 2020. Rapid, convenient and efficient kit-independent detection of SARS-CoV-2 RNA. Journal of Virological Methods 286:113965.
  25. Nchioua R, Bosso M, Kmiec D, Kirchhoff F. 2020. Cellular Factors Targeting HIV-1 Transcription and Viral RNA Transcripts. 5. Viruses 12:495.
  26. Nchioua R, Kmiec D, Müller JA, Conzelmann C, Groß R, Swanson CM, Neil SJD, Stenger S, Sauter D, Münch J, Sparrer KMJ, Kirchhoff F. 2020. Sars-cov-2 is restricted by zinc finger antiviral protein despite preadaptation to the low-cpg environment in humans. mBio 11:1–19.
  27. Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD. 2020. HIV-1 Vpu Downregulates Tim-3 from the Surface of Infected CD4 + T Cells. Journal of Virology 94.
  28. Prévost J, Tolbert WD, Medjahed H, Sherburn RT, Madani N, Zoubchenok D, Gendron-Lepage G, Gaffney AE, Grenier MC, Kirk S, Vergara N, Han C, Mann BT, Chénine AL, Ahmed A, Chaiken I, Kirchhoff F, Hahn BH, Haim H, Abrams CF, Smith AB, Sodroski J, Pazgier M, Finzi A. 2020. The HIV-1 ENV GP120 inner domain shapes the PHE43 cavity and the CD4 binding site. mBio 11:1–26.
  29. Schütz D, Ruiz-Blanco YB, Münch J, Kirchhoff F, Sanchez-Garcia E, Müller JA. 2020. Peptide and peptide-based inhibitors of SARS-CoV-2 entry. Advanced drug delivery reviews doi.org/10.1016/j.addr.2020.11.007.
  30. Sieste S, Mack T, Lump E, Hayn M, Schütz D, Röcker A, Meier C, Kirchhoff F, Knowles T, Ruggeri FS, Synatschke C, Münch J, Weil T. 2020. Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction. ChemRxiv doi.org/10.26434/CHEMRXIV.13129709.V1.
  31. Sokkar P, Harms M, Stürzel C, Gilg A, Kizilsavas G, Raasholm M, Preising N, Wagner M, Ständker L, Weidinger G, Münch J, Sanchez-Garcia E. 2020. Biomolecular models of EPI-X4 binding to CXCR4 allow the rational optimization of peptides with therapeutic potential. bioRxiv 2020.10.23.352708.
  32. Srinivasachar Badarinarayan S, Shcherbakova I, Langer S, Koepke L, Preising A, Hotter D, Kirchhoff F, Sparrer KMJ, Schotta G, Sauter D. 2020. HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression. Nucleic Acids Research 48:10890–10908.
  33. Thoms M, Buschauer R, Ameismeier M, Koepke L, Denk T, Hirschenberger M, Kratzat H, Hayn M, MacKens-Kiani T, Cheng J, Straub JH, Stürzel CM, Fröhlich T, Berninghausen O, Becker T, Kirchhoff F, Sparrer KMJ, Beckmann R. 2020. Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science 369:1249–1256.
  34. Vegi NM, Chakrabortty S, Zegota MM, Kuan SL, Stumper A, Rawat VPS, Sieste S, Buske C, Rau S, Weil T, Feuring-Buske M. 2020. Somatostatin receptor mediated targeting of acute myeloid leukemia by photodynamic metal complexes for light induced apoptosis. Scientific Reports 10:1–10.
  35. Volcic M, Sparrer KMJ, Koepke L, Hotter D, Sauter D, Stürzel CM, Scherer M, Stamminger T, Hofmann TG, Arhel NJ, Wiesmüller L, Kirchhoff F. 2020. Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1. Nature Microbiology 5:1247–1261.
  36. Weil T, Groß R, Röcker A, Bravo-Rodriguez K, Heid C, Sowislok A, Le MH, Erwin N, Dwivedi M, Bart SM, Bates P, Wettstein L, Müller JA, Harms M, Sparrer K, Ruiz-Blanco YB, Stürzel CM, von Einem J, Lippold S, Read C, Walther P, Hebel M, Kreppel F, Klärner FG, Bitan G, Ehrmann M, Weil T, Winter R, Schrader T, Shorter J, Sanchez-Garcia E, Münch J. 2020. Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers. Journal of the American Chemical Society 142:17024–17038.