Sepsis is a life-threatening condition characterized by organ dysfunction caused by microorganisms. Despite advances in intensive care, approximately 50% of sepsis patients succumb to the illness within three months, and 75% die within four years. Therefore, sepsis poses a significant and daunting challenge to both our immune and interconnected organ systems, as well as our society as a whole.

To tackle this challenge, our team focuses on understanding the role of innate defence systems and organ crosstalk in various sepsis models. We also strive to apply these findings to the clinical setting. A key area of interest lies in the real-time monitoring of the immune response and subsequent targeted modulation, including the activation of complement products, to counteract the intricate mechanisms involved in sepsis. Thereby, we anticipate enhancing organ function and improving clinical outcomes in the future.