Poly­trauma, as a life-​threatening injury to various body regi­ons, con­ti­nues to be the lea­ding cause of death until the age of 45 years. After poly­trauma, mas­sive blee­ding with deve­lo­p­ment of ahe­mor­rha­gic shock repres­ents an addi­tio­nal life-​threatening con­di­tion, lea­ding to ina­de­quate tis­sue per­fu­sion and organ dys­func­tion The trau­ma­tic impact leads to gene­ra­tion of dif­fe­rent "dan­ger mole­cu­les" that trig­ger a local and sys­temic inflam­ma­tory response. Our group inves­ti­ga­tes the under­ly­ing mole­cu­lar and cel­lu­lar mecha­nisms and focu­ses par­ti­cu­larly on the role shock as major dri­ver of the inflam­ma­tory response and cel­lu­lar dys­func­tion. We inves­ti­gate how dys­func­tion of both, the sta­tic defense (bar­riers) and dyna­mic defense (immu­nity) con­tri­bute to the deve­lo­p­ment of the fea­red mul­ti­or­gan failure with a focus on the lungs, gut and kid­neys. Pro­mi­sing the­ra­peu­tic immu­n­o­mo­du­la­tory approa­ches are being pur­sued to improve the post­trau­ma­tic response and cli­ni­cal out­come.

Group Lea­der

Profilbild von Dr. rer. nat. Ludmila Lupu

Dr. rer. nat. Lud­mila Lupu

Group Lea­der AG Poly­trauma - Shock

Kon­takt
In the Emergency Room, the patient receives rapid synchronic diagnostic and care by an interdisciplinary expert team. In close collaboration with the Dept. of Trauma Surgery (Prof. F. Gebhard) and Dept. of Anesthesiology (Prof. B. Jungwirth) the polytrauma study at Ulm Hospital evaluates the immune and organ response of the patient after severe tissue injury.

In the Emer­gency Room, the pati­ent recei­ves rapid syn­chro­nic dia­gno­stic and care by an inter­di­sci­pli­nary expert team.

In close col­la­bo­ra­tion with the Dept. of Trauma Sur­gery (Prof. F. Geb­hard) and Dept. of Anesthe­sio­logy (Prof. B. Jung­wirth) the poly­trauma study at Ulm Hos­pi­tal eva­lua­tes the immune and organ response of the pati­ent after severe tis­sue injury.

 

 

Publi­ca­ti­ons


Simul­ta­neous C5 and CD14 inhi­bi­tion limits inflam­ma­tion and organ dys­func­tion in pig poly­trauma.Lupu L, Horst K, Gre­ven J, Mert Ü, Lud­vik­sen JAK, Pet­ter­sen K, Lau C, Li Y, Pal­mer A, Qin K, Zhang X, Mayer B, van Griens­ven M, Huber-​Lang M, Hil­de­brand F, Moll­nes TE.Front Immu­nol. 2022 Aug 18;13:952267. doi: 10.3389/fimmu.2022.952267

INTE­STI­NAL DAMAGE AND IMMUNE RESPONSE AFTER EXPE­RI­MEN­TAL BLUNT ABDO­MI­NAL TRAUMA.
Hauss­ner F, Maitz A, Rasche V, Hoff­mann A, Brau­mül­ler S, Lupu L, Igna­tius A, Neff TA, Pal­mer A, Huber-​Lang M.Shock. 2022 Oct 1;58(4):332-340. doi: 10.1097/SHK.0000000000001986. Epub 2022 Aug 26.PMID: 36018298

Hemor­rha­gic Shock Indu­ces a Rapid Tran­scripto­mic Shift of the Immune Balance in Leu­ko­cy­tes after Expe­ri­men­tal Mul­ti­ple Injury.
Debler L, Pal­mer A, Brau­mül­ler S, Klohs B, Moll­nes TE, Holz­mann K, Huber-​Lang M, Halb­ge­bauer R.Media­tors Inflamm. 2021 Jan 27;2021:6654318. doi: 10.1155/2021/6654318. eColl­ec­tion 2021

Role of the C5a-C5a recep­tor axis in the inflam­ma­tory respon­ses of the lungs after expe­ri­men­tal poly­trauma and hemor­rha­gic shock.
Cha­kra­borty S, Win­kel­mann VE, Brau­mül­ler S, Pal­mer A, Schultze A, Klohs B, Igna­tius A, Vater A, Fau­ler M, Frick M, Huber-​Lang M.Sci Rep. 2021 Jan 25;11(1):2158. doi: 10.1038/s41598-020-79607-1.PMID: 33495506 

Temporal-​spatial organ response after blast-​induced expe­ri­men­tal blunt abdo­mi­nal trauma.
Maitz A, Hauss­ner F, Brau­mül­ler S, Hoff­mann A, Lupu L, Wach­ter U, Rader­ma­cher P, Braun CK, Wilke HJ, Vogt M, Igna­tius A, Halb­ge­bauer R, Bettac L, Barth TFE, Huber-​Lang M, Pal­mer A.FASEB J. 2021 Dec;35(12):e22038. doi: 10.1096/fj.202100995R.

Eva­lua­tion of the gut micro­biome in asso­cia­tion with bio­lo­gi­cal signa­tu­res of inflam­ma­tion in murine poly­trauma and shock.
Appiah SA, Foxx CL, Lang­gart­ner D, Pal­mer A, Zam­brano CA, Brau­mül­ler S, Schae­fer EJ, Wach­ter U, Elam BL, Rader­ma­cher P, Stam­per CE, Heinze JD, Sala­zar SN, Luthens AK, Arnold AL, Reber SO, Huber-​Lang M, Lowry CA, Halb­ge­bauer R.Sci Rep. 2021 Mar 23;11(1):6665. doi: 10.1038/s41598-021-85897-w.

Inflam­ma­tion, Throm­bo­sis, and Destruc­tion: The Three-​Headed Cer­be­rus of Trauma- and SARS-​CoV-2-​Induced ARDS.
Lupu L, Pal­mer A, Huber-​Lang M.Front Immu­nol. 2020 Sep 25;11:584514. doi: 10.3389/fimmu.2020.584514. eColl­ec­tion 2020.PMID: 33101314 

Com­ple­ment C5a Indu­ces Pro-​inflammatory Microve­sicle Shed­ding in Severely Inju­red Pati­ents.
Karasu E, Dem­mel­maier J, Kel­ler­mann S, Holz­mann K, Köhl J, Schmidt CQ, Kal­bitz M, Geb­hard F, Huber-​Lang MS, Halb­ge­bauer R.Front Immu­nol. 2020 Sep 2;11:1789. doi: 10.3389/fimmu.2020.01789. eColl­ec­tion 2020.

 

 

Team

Stu­dents
  • Mar­tin Mösen­lech­ner