Together with the coagulation and contact system, the complement system forms the intravascular fluid-phase innate immunity. These three cascades are primarily involved in sensing and elimination of pathogens (e.g., bacteria). However, research in the last years revealed that this proposed “C3-defence” contributes significantly to multiple processes such as organ development or tissue regeneration. Therefore, a strict regulation at different levels is necessary. This self-control can be disturbed in acute diseases or by genetic alterations and requires therapeutic modulation. Thus, development of numerous inhibitors acting at different levels of the highly interacting cascades are of great interest.

Our research group focuses on the mechanistic basis of the coagulation, complement and contact cascade and its therapeutic modulation. We apply sophisticated methods for the evaluation of complement/coagulation/contact functions and develop novel detection methods, which allow investigation of interactions with further humoral/cellular systems and their translation to disease-relevant models.

Group Leader

Profilbild von Dr. rer. nat. Marco Mannes

Dr. rer. nat. Marco Mannes

Group Leader AG C3 Defense

Kontakt
The coagulation (left) and complement (right) cascade closely interact upon a traumatic or septic challenge.
The coagulation (left) and complement (right) cascade closely interact upon a traumatic or septic challenge.

 

 

Publications

1. Mannes M., Dopler A., Zolk O., Lang SJ., Halbgebauer R., Höchsmann B., Skerra A., Braun CK., Huber-Lang M., Schrezenmeier H., Schmidt CQ.: Complement inhibition at the level of C3 and C5: mechanistic reasons for ongoing terminal pathway activity. Blood,2021,137(4):443-455

2. Mannes M., Mastellos DC., Ekdahl KN., Nilsson B., Yancopoulou D., Lambris JD., Huber-Lang M.: Complement C3 activation in the ICU: Disease and Therapy as Bonnie and Clyde. Seminars in Immunology, 2022, 101640

3. Mannes M., Schmidt CQ., Nilsson B., Ekdahl KN., Huber-Lang M.: Complement as driver of systemic inflammation and organ failure in trauma, burn, and sepsis. Seminars in Immunopathology, 2021, 43(6):773-788

4. Mannes M., Halbgebauer R, Wohlgemuth L, Messerer DAC, Savukoski S, Schultze A, Berger B, Knapp CL, Schmidt CQ, Fürst D, Hillmer M, Siebert R, Eriksson O, Persson B, Nilsson B, Nilsson Ekdahl K, Huber-Lang M.: Combined heterozygous genetic variations in Complement C2 and C8B: An explanation for multidimensional immune imbalance? Journal of innate Immunity, 2023, 15(1):412-427

5. Mannes M., Dopler A., Huber-Lang M., Schmidt CQ.: Tuning the Functionality by Splicing: Factor H and Its Alternative Splice Variant FHL-1 share a Gene but not all Functions. Frontiers in Immunology, 2020, 11:596415

Further publications: PubMed Marco Mannes

Team

Studierende
  • Lena Bohnet – Medizinstudentin
  • Niklas Zankl – Medizinstudent
 
Alumni
  • Frieder Scheibenberger, Medizinstudent
  • Doreen Spiegelburg, Medizinstudentin
  • Frederik Müller, Medizinstudent
  • Amadeo Klitzing, Medizinstudent