Priv.-Doz. Dr. med. Mathias Wittau

• Approbation (2001)
• Promotion (2000)
• Facharzt für Chirurgie (2007)
• Facharzt für Viszeralchirurgie
• Zusatzbezeichnung spezielle Viszeralchirugie (2012)
• Habilitation (2017)
• Seit 2008 Oberarzt

Gewebekonzentrationen von Antibiotika (Carbapenemen) in adipösen Patienten

Gewebekonzentrationen von Ertapenem in intraabdominellen Organen

• Hepato-Gastroenterology, National Editor
• Fachbeirat der "DEUTSCHE STIFTUNG ORGANTRANSPLANTATION", Region Baden-Württemberg, 2008, 2009, 2010, 2011
• Deutsche Transplantations-Gesellschaft International Association of Surgeons, Gastroenterologists and Oncologists
• Fachzeitschrift: Oncology, Gastroenterology and Hepatology Reports, Mitglied des Editorial Advisory Boards seit 2012

• Wiskirchen J, Grönewäller EF,Kehlbach R, Heinzelmann F, Wittau M, Rodemann HP, Claussen CD,Duda SH Long-term effects of repetitive exposure to a static magnetic field (1.5 T) on proliferation of human fetal lungfibroblasts. Magnet. Res. Med. 41 (1999): 464-468
• Wiskirchen J, Gröneweller E F, Heinzelmann F, Kehlbach R, Rodegerdts E, Wittau M, Rodemann H P, Claussen C D, Duda S H: Human fetal lung fibroblasts: in vitro study of repetitive magnetic field exposure at 0.2, 1.0 and 1.5 T Radiology 215 (2000): 858-862
• Wittau M, Beyer C, Krier C, Hupp T: Operationsstrategieänderung durch somatosensorisch evozierte Potenziale (SSEP) bei der Carotis-TEA. Ein interessanter Fall mit intraoperativ entstandener Carotis-Dissektion. Gefäßchirurgie; 6 (2001): 210-13
• Isenmann R, Wittau M, Henne-Bruns D Candidainfektionen in der Abdominalchirurgie. Chemotherapie Journal 12 (Suppl. 22) (2003): 3-6
• Wittau M, Weber D, Reher B, Link KH, Henne-Bruns D, Siech M „Bodypacker“ als chirurgischer Notfall. Wem gehört das Rauschgift? Chirurg 75(4) (2004): 436-41.
• Henne-Bruns D, Wittau M, Isenmann R. Is antibiotic prophylaxis in necrotizing pancreatitis evidence-based? European Gastroenterology Review 2005 - September 205
• Wolff S, Xiao Z, Wittau M, Süssner N, Stöter M, Knippschild U: Interaction of casein kinase 1 delta (CK1 delta) with the light chain LC2 of microtubule associated protein 1A (MAP1A). Biochim Biophys Acta. 2005 Sep 10;1745(2):196-206.
• Knippschild U, Wolff S, Giamas G, Brockschmidt C, Wittau M, Würl PU, Eismann T, Stöter M: The role of the casein kinase 1 (CK1) family in different signaling pathways linked to cancer development. Onkologie. 2005 Oct;28(10):508-14. Epub 2005 Sep 19.
• Wittau M, Wolff S, Xiao Z, Henne-Bruns D, Knippschild U. Die stressinduzierte Casein Kinase 1 delta kann die Spindeldynamik durch direkte Interaktion mit dem Mikrotubuli assoziierten Protein MAP1A beeinflussen. Chirurgisches Forum 2005, Deutsche Gesellschaft für Chirurgie 2005;34: 37-39, DOI: 10.1007/3-540-26560-0_13
• Wittau M, Wagner E, Kaever V, Koal T, Henne-Bruns D, Isenmann R. Intraabdominal tissue concentration of ertapenem. J Antimicrob Chemoth 2006, 57: 312-6. Hupp T, Özkaya S, Wittau M: Perioperative intravenöse Applikation von Heparinen in der rekonstruktiven Carotis-Chirurgie. Vascular Care 2008, 15: 52-61.
• Wittau M, Hohl K, Mayer J, Henne-Bruns D, Isenmann: The weak evidence base for antibiotic prophylaxis in severe acute pancreatitis. Hepatogastroenterology 2008 Nov-Dec;55(88):2233-7
• Ganzemüller J, Keller F, Hartmann B, Wittau M. Indikation und Effekt der Plasmapherese bei Nierentransplantierten. Transplantationsmedizin 2010; 22: 295-300.
• Wittau M, Scheele J, Gölz I, Henne-Bruns D, Isenmann R. Changing role of surgery in necrotizing pancreatitis: A single-center experience. Hepato-Gastroenterology 2010; 57:1300-1304.
• Wittau M, Mayer B, Scheele J, Henne-Bruns D, Dellinger EP, Isenmann R. Systematic review and meta-analysis of antibiotic prophylaxis in severe acute pancreatitis. Scand J Gastroenterol. 2010 Nov 10. [Epub ahead of print].
• Oğlakcιoğlu MT, Henne-Bruns D,Wittau M. Unerlaubte Einfuhr von Betäubungsmitteln durch „Bodypacking” – Rechtliche und medizinische Grundlagen. NstZ-Neue Zeitschrift für Strafrecht 2011;2: 73-75.
• Wittau M, Scheele J, Bulitta JB, Mayer B, Kaever V, Burhenne H, Henne-Bruns D, Isenmann R, Brockschmidt C. Pharmacokinetics of ertapenem in colorectal tissue. Chemotherapy 2011; 57:437-448
• Scheele J, Barth TF, Wittau M, Juchems M, Henne-Bruns D, Kornmann M. Cystic teratoma of the pancreas. Anticancer Res. 2012 Mar;32(3):1075-80.
•  Brockschmidt C, Huber N, Paschke S, Hartmann B, Henne-Bruns D, Wittau M. Minimal access kidney transplant: a novel technique to reduce surgical tissue trauma. Exp Clin Transplant. 2012 Aug;10(4):319-24.
• Dellinger EP, Forsmark CE, Layer P, Lévy P, Maraví-Poma E, Petrov MS, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Abu HM, Abu-Zidan F, Acosta J, Ainsworth A, Aizcorbe GM, Alagozlu H, Alaref S, Albeniz AE, Alhajeri A, Almeida I, Almeida J, Amano H, Ammori B, Andersson R, Andrén-Sandberg A, Ardengh J, Arroyo-Sanchez A, Arvanitakis M, Ashley S, Aygencel G, Ayoub W, Baillie J, Bala M, Ball C, Baron T, Barreto S, Basaranoglu M, Beger H, Bernal MV, Bharwani N, Bhasin D, Bong J, Botoi G, Bruennler T, Cairoli E, Carter C, Cernea D, Chari S, Charnley R, Chooklin S, Cochior D, Col C, Conwell D, Correia M, Dambrauskas Z, Darvas K, De Campos T, De Casasola G, De Waele J, Del Chiaro M, Delle Fave G, Dellinger E, de-Madaria E, di Sebastiano P, Diuzheva T, Duarte-Rojo A, Fagenholz P, Farkas G, Farre VA, Fernandez-Del CC, Forsmark C, Friess H, Frossard J, Gandhi V, Gardner T, Gloor B, Gluk M, Goltsov V, Guevara-Campos J, Gumbs A, Hackert T, Hauser G, Horvath K, Howard T, Igarashi H, Ioannidis O, Jaber S, James F, Jha R, Juneja D, Kamisawa T, Kandasami P, Kantarcioglu M, Kapoor V, Karakan T, Kaya E, Khaliq A, Kiriyama S, Kochhar R, Konstantinou G, Kylänpää M, Lankisch P, Laplaza SC, Lata J, Layer P, Leppäniemi A, Levy P, Lopez A, López CV, Lujano-Nicolas L, Lund H, Lytras D, Macaya RL, Machado M, Macias RM, Mann O, Maravi-Poma E, Marincas M, Marwah S, Mas E, Matheus A, Meier R, Mennecier D, Mentula P, Mifkovic A, Mofidi R, Mole D, Morris-Stiff G, Mossner J, Muftuoglu M, Munsell M, Nathens A, Neri V, Nöjgaard C, Nordback I, Ocampo C, Oláh A, Olejnik J, Oreilly D, Oria A, Panek J, Papachristou G, Parekh D, Parks R, Passaglia C, Pearce C, Pellegrini D, Perez-Mateo M, Petrov M, Pettila V, Pezzilli R, Pitchumoni C, Pongprasobchai S, Poves PI, Puolakkainen P, Pupelis G, Radenkovic D, Rahman S, Regidor SE, Repiso A, Rodrigo L, Rosseland A, Rydzewska G, Sánchez-Izquierdo RJ, Savides T, Scaglione M, Serrablo A, Servin-Torres E, Sethu I, Sezgin O, Shankar-Hari M, Shimosegawa T, Singer M, Sinha S, Siriwardena A, Sjoberg BT, Skipworth J, Soriano F, Sotoudehmanesh R, Spanier B, Stabuc B, Stroescu C, Szentkereszty Z, Takacs T, Takada T, Takeda K, Takeyama Y, Tang W, Tanjoh K, Tarnasky P, Teich N, Tellado J, Tenner S, Thomson A, Tireli M, Tong Z, Triantopoulou C, Uomo G, Uy M, van Geenen E, Velasco GA, Vettoretto N, Vollmer C Jr, Wada K, Warshaw A, Weinbroum A, Whitcomb D, Wilson J, Windsor J, Wittau M, Wu B, Wysocki A, Yan QE, Yasuda T, Yu C, Zerem E, Zhou X, Zubia OF, Zyromski N. Determinant-Based Classification of Acute Pancreatitis Severity: An International Multidisciplinary Consultation. Ann Surg. 2012. Aug 8. [Epub ahead of print].
• Layer P, Dellinger EP, Forsmark CE, Lévy P, Maraví-Poma E, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Petrov MS;.Abu Hilal M, Abu-Zidan FM, Acosta JM, Ainsworth AP, Alagozlu H, Al'aref SJ, Alhajeri A, Almeida JL, Ammori BJ, Andersson R, Ardengh JC, Arroyo-Sanchez AS, Arvanitakis M, Ashley SW, Aygencel G, Ayoub WA, Baillie J, Bala M, Ball GG, Banks PA, Baron TH, Barreto SG, Basaranoglu M,Beger HG, Bernal Monterde V, Besselink MG, Bharwani N, Bhasin DK, Bong JJ, Botoi G, Bruennler T, Bruno MJ, Cairoli E, Carter CR, Cernea D,Chari ST, Chooklin S, Cochior D, Col C, Conwell DL, Correia MI, Dambrauskas Z, Darvas K, De Campos T, De Casasola GG, De Waele JJ, del Chiaro M, Delle Fave G, Dellingerq EP, de-Madaria E, Dervenis C, di Sebastiano P, Diuzheva TG, Duarte-Rojo A, Fagenholz PJ, Farkas G, Farre Viladrich A, Fernandez-del Castillo C, Forsmark CE, Friess H, Frossard JL, Gandhi V, Gardner TB, Garg PK, Gloor B, Gluk M, Goltsov VR, Guevara-Campos J, Gumbs AA, Hackert T, Hauser G, Horvath KD, Howard TJ, Igarashi H, Ioannidis O, Jaber S, James FE, Jha RK, Johnson CD, Juneja D,Kamisawa T, Kandasami P, Kantarcioglu M, Kapoor VK, Karakan T, Kaya E, Khaliq A, Kiriyama S, Kochhar R, Konstantinou GN, Kylänpää ML,Lankisch PG, Lata J, Layer P, Lerch MM, Levy P, Lopez A, Lujano-Nicolas LA, Lund H, Lytras D, Machado MC, Macias Rodriguez MA, Mann O,Maravi-Poma E, Marincas M, Marwah S, Mas E, Matheus AS, Mayerle J, Meier R, Mennecier D, Mifkovic A, Mole DJ, Morris-Stiff G, Mossner J,Muftuoglu MA, Munsell MA, Nathens AB, Neri V, Nöjgaard C, Nordback I, Ocampo C, Olejnik J, O'Reilly DA, Oria A, Panek J, Papachristou GI,Parekh D, Parks RW, Passaglia C, Pearce CB, Pellegrini D, Perez-Mateo M, Petrov MS, Pettila V, Pezzilli R, Pitchumoni CS, Pongprasobchai S,Puolakkainen P, Pupelis G, Radenkovic DV, Rahman SH, Rau BM, Repiso A, Rodrigo L, Rydzewska G, Savides TJ, Scaglione M, Serrablo A,Servin-Torres E, Sethu I, Sezgin O, Shankar-Hari M, Shimosegawa T, Singer MV, Sinha SK, Siriwardena AK, Sjoberg Bexelius T, Skipworth JR,Soriano FG, Sotoudehmanesh R, Spanier BW, Stabuc B, Stroescu C, Szentkereszty Z, Takacs T, Takada T, Takeda K, Takeyama Y, Talukdar R,Tang W, Tanjoh K, Tarnasky PR, Teich N, Tellado JM, Tenner S, Thomson A, Tireli M, Tong Z, Triantopoulou C, Uomo G, Uy MC, van Geenen EJ,Vege SS, Velasco Guardado A, Vettoretto N, Wada K, Warshaw AL, Whitcomb DC, Wilson JS, Windsor JA, Wittau M, Wu BU, Wysocki AP, Yan Quiros E, Yasuda T, Yu C, Zerem E, Zhou X, Zyromski NJ. Determinant-based classification of acute pancreatitis severity. International multidisciplinary classification of acute pancreatitis severity: the 2013 German edition. Z Gastroenterol. 2013 Jun;51(6):544-50. doi: 10.1055/s-0033-1335526. Epub 2013 Jun 5.
• Mayer B, Keller F, Syrovets T, Wittau M. Estimation of half-life periods in nonlinear data with fractional polynomials. Stat Methods Med Res. 2013 Sep 2. [Epub ahead of print]
• Brockschmidt C, Köksal E, Mayer B, Henne-Bruns D, Wittau M. The minimal-access kidney transplantation technique in living-donor transplantation: results from a retrospective analysis. Transplant Proc. 2014 Jun;46(5):1286-9. doi: 10.1016/j.transproceed.2013.12.064.
• Lemke J, Scheele J, Schmidt S, Wittau M, Henne-Bruns D: Massive gastric dilatation caused by eating binges demanding surgical intervention: a case report. GMS Interdiscip Plast Reconstr Surg DGPW 2014; 3:Doc09 (20141103)
• Scheele J, Lemke J, Barth TF, Juchems M, Wittau M, Kornmann M, Henne-Bruns D. Chondroid hamartoma of the liver. GMS Interdiscip Plast Reconstr Surg DGPW. 2014 Dec 17;3:Doc16. doi: 10.3205/iprs000057. eCollection 2014.PMID:26504727.
• Wittau M, Scheele J, Kurlbaum M, Brockschmidt C, Wolf AM, Hemper E, Henne-Bruns D, Bulitta JB. Population Pharmacokinetics and Target Attainment of Meropenem in Plasma and Tissue of Morbidly Obese Patients after Laparoscopic Intraperitoneal Surgery. Antimicrob Agents Chemother. 2015 Oct;59(10):6241-7. doi: 10.1128/AAC.00259-15. Epub 2015 Jul 27.
• Wittau M, Paschke S, Kurlbaum M, Scheele J, Ly NS, Hemper E, Kornmann M, Henne-Bruns D, Bulitta JB. Population Pharmacokinetics and Target Attainment of Ertapenem in Plasma and Tissue Assessed via Microdialysis in Morbidly Obese Patients after Laparoscopic Visceral Surgery. Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e00952-16. doi: 10.1128/AAC.00952-16. Print 2017 Jan.
• Kloth C, Beck A, Wittau M, Thaiss WM, Vogele D, Beer M, Schmidt SA. Rare case of a pancreatic neoplasm in an older patient. Radiologe. 2020 Jul 23. doi: 10.1007/s00117-020-00725-y. 
• Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis. Bulitta JB, Jiao Y, Drescher SK, Oliver A, Louie A, Moya B, Tao X, Wittau M, Tsuji BT, Zavascki AP, Shin BS, Drusano GL, Sörgel F, Landersdorfer CB. Clin Pharmacokinet. 2019 Feb;58(2):143-156.
• Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib. Böhm MJ, Marienfeld R, Jäger D, Mellert K, von Witzleben A, Brüderlein S, Wittau M, von Baer A, Schultheiss M, Mayer-Steinacker R, Rücker FG, Möller P, Bullinger L, Barth TFE. Sarcoma. 2019 Jan 21;2019:3914232. doi: 10.1155/2019/3914232. eCollection 2019.
• Pelvic exenteration as ultimate ratio for gynecologic cancers: single-center analyses of 37 cases. de Gregorio N, de Gregorio A, Ebner F, Friedl TWP, Huober J, Hefty R, Wittau M, Janni W, Widschwendter P. Arch Gynecol Obstet. 2019Jul;300(1):161-168
• Allgöwer C, Kretz AL, von Karstedt S, Wittau M, Henne-Bruns D, Lemke J. Friend or Foe: S100 Proteins in Cancer. Cancers 2020,12(8). https://doi.org/10.3390/cancers12082037.
• Kloth C, Beck A, Wittau M, Thaiss WM, Vogele D, Beer M, Schmidt SA. Rare case of a pancreatic neoplasm in an older patient. Radiologe. 2020 Jul 23. doi: 10.1007/s00117-020-00725-y.

•