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Studienname/Sponsor
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Entität(en)
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Prüfsubstanz
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20150161 Amgen
Phase 1 First in Human Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 176 in Subjects With Relapsed or Refractory Multiple Myeloma and Subjects With Relapsed or Refractory Acute Myeloid Leukemia.
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AML, Multiple Myeloma
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MCL1 Inhibitor
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CPDR001x2x01b Novartis
An open-label, multi-center rollover protocol for continued characterization of safety and tolerability for subjects who have participated in a Novartis-sponsored spartalizumab study as single agent or in combination with other study treatments.
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Solide Tumore
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Check point inhibitor
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IMGN632-0802
A Phase 1b/2 Study of IMGN632 as Monotherapy or Combination with Venetoclax and/or Azacitidine for Patients with CD123-Positive Acute Myeloid Leukemia.
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AML (CD123 pos.)
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Anti-CD123 ADC
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20180257 Amgen
A Phase 1b Open-label Study to Investigate the Safety and Pharmacoki-netics of Administration of Subcutaneous Blinatumomab for the Treatment of adults with Relapsed or Refractory B cell Precursor Acute Lympho-blastic Leukemia (R/R B-ALL).
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ALL
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Anti-CD19 bispezifischer AK
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UC02-123-01
Multicenter, open-label, adaptive design phase I trial with genetically modified T-cells carrying Universal Chimeric Antigen Receptors (UniCAR02-T) in combination with CD123 target module (TM123) for the treatment of patients with hematologic and lymphatic malignancies positive for CD12.
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AML, B-ALL, BPDCN (CD123 pos.)
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CD123 CAR-T-cell
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UC02-PSMA-01
Multicenter, Open-label, Adaptive Design Phase I Trial with Genetically Modified T-cells Carrying Universal Chimeric Antigen Receptors (UniCAR02-T) in Combination with PSMA peptide Target Module (TMpPSMA) for the Treatment of Patients with Progressive Disease after Standard Systemic Therapy in Cancers with Positive PSMA Marker.
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PSMA pos. cancer i.e. prostate cancer
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PSMA peptide CAR-T-cell
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CADPT01C12101 Novartis
A Phase Ib, multicenter, open-label dose escalation and expansion platform study of select drug combinations in adult patients with advanced or metastatic BRAF V600 colorectal cancer.
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BRAF V600 colon cancer
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Dabrafenib mit ERK1/2 inhibitor
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PANTAX Scandion Oncology A/S
An open-label phase Ib prospective clinical trial to investigate safety, tolerablity and maximum tolerated dose for SCO-101 in combination with gemcitabine and nab-paclitaxel in inoperable pancreatic cancer patients.
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Pancreatic Cancer
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inhibitor of ATP-Binding Cassette efflux pumps and SRPK1 kinase
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NOA-26 - IT-PD1
Intrathecal application of PD1 antibody in metastatic solid tumors with leptomeningeal disease
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Leptomeningeal disease in primary tumors with authorized indication for intravenous treatment with nivolumab, pembrolizumab or atezolizumab
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Intrathecal application of the PD1 antibody nivolumab
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BO43243
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
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Relapsed or Refractory CLL
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Mosenutuzumab, Anti-CD20 bispezifischer AK
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BO41932 - Rekrutierung aktuell ausgesetzt
Tumor-agnostic precision immuno-oncology and somatic targeting rational for you (TAPISTRY) Phase II platform trial
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unresectable, locally advanced or metastatic solid tumors determined to harbor specific oncogenic genomic alterations
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Entrectinib, Alectinib, Atezolizumab, Ipatasertib, Trastuzumab Emtasine, Idasanutlin, Inavolisib, Belvarafenib, Pralsetinib
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